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Clinical & Experimental Metastasis
Published in: Clinical & Experimental Metastasis 5/2010

01-05-2010 | Research Paper

Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis

Authors: Ryan R. Gordon, Michele La Merrill, Kent W. Hunter, Peter Sørensen, David W. Threadgill, Daniel Pomp

Published in: Clinical & Experimental Metastasis | Issue 5/2010

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Abstract

Breast cancer is a complex disease resulting from a combination of genetic and environmental factors. Among environmental factors, body composition and intake of specific dietary components like total fat are associated with increased incidence of breast cancer and metastasis. We previously showed that mice fed a high-fat diet have shorter mammary cancer latency, increased tumor growth and more pulmonary metastases than mice fed a standard diet. Subsequent genetic analysis identified several modifiers of metastatic mammary cancer along with widespread interactions between cancer modifiers and dietary fat. To elucidate diet-dependent genetic modifiers of mammary cancer and metastasis risk, global gene expression profiles and copy number alterations from mammary cancers were measured and expression quantitative trait loci (eQTL) identified. Functional candidate genes that colocalized with previously detected metastasis modifiers were identified. Additional analyses, such as eQTL by dietary fat interaction analysis, causality and database evaluations, helped to further refine the candidate loci to produce an enriched list of genes potentially involved in the pathogenesis of metastatic mammary cancer.
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Metadata
Title
Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis
Authors
Ryan R. Gordon
Michele La Merrill
Kent W. Hunter
Peter Sørensen
David W. Threadgill
Daniel Pomp
Publication date
01-05-2010
Publisher
Springer Netherlands
Published in
Clinical & Experimental Metastasis / Issue 5/2010
Print ISSN: 0262-0898
Electronic ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-010-9326-z

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