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Cancer Causes & Control
Published in: Cancer Causes & Control 5/2019

01-05-2019 | Original Paper

Flavonoids and bladder cancer risk

Authors: Marta Rossi, Panagiota Strikoudi, Maria-Eleni Spei, Maria Parpinel, Diego Serraino, Maurizio Montella, Massimo Libra, Carlo La Vecchia, Valentina Rosato

Published in: Cancer Causes & Control | Issue 5/2019

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Abstract

Purpose

Flavonoids have drawn attention because of their antioxidant capacity and anti-carcinogenic effect in various types of cancer. A limited number of studies has investigated their potential effect on the risk of bladder cancer, with inconsistent results.

Methods

We analyzed data from an Italian case–control study including 690 incident bladder cancer cases and 665 controls admitted to the same network of hospitals for acute, non-neoplastic, non tobacco-related diseases. Subjects were interviewed using a reproducible and validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones and flavonols. We estimated odds ratios (ORs) through multiple logistic regression models, including terms for potential confounding factors, including tobacco smoking and total energy intake.

Results

We found an inverse association between isoflavones (OR for the highest compared to the lowest quintile of intake = 0.56, 95% CI 0.37–0.84) and flavones (OR = 0.64, 95% CI 0.44–0.95) and bladder cancer. Non-significant inverse association was found for flavan-3-ols (OR = 0.70), flavonols (OR = 0.85) and total flavonoids (OR = 0.76). The results were consistent for non-muscle-invasive and muscle-invasive bladder cancers.

Conclusions

Our data indicate an inverse association between isoflavones and flavones with respect to bladder cancer risk.
Appendix
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Metadata
Title
Flavonoids and bladder cancer risk
Authors
Marta Rossi
Panagiota Strikoudi
Maria-Eleni Spei
Maria Parpinel
Diego Serraino
Maurizio Montella
Massimo Libra
Carlo La Vecchia
Valentina Rosato
Publication date
01-05-2019
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 5/2019
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-019-01158-2

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