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Cancer Causes & Control
Published in: Cancer Causes & Control 7/2016

Open Access 01-07-2016 | Original paper

Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort

Authors: Yunxia Lu, Amanda J. Cross, Neil Murphy, Heinz Freisling, Ruth C. Travis, Pietro Ferrari, Verena A. Katzke, Rudolf Kaaks, Åsa Olsson, Ingegerd Johansson, Frida Renström, Salvatore Panico, Valeria Pala, Domenico Palli, Rosario Tumino, Petra H. Peeters, Peter D. Siersema, H. B. Bueno-de-Mesquita, Antonia Trichopoulou, Eleni Klinaki, Christos Tsironis, Antonio Agudo, Carmen Navarro, María-José Sánchez, Aurelio Barricarte, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Antoine Racine, Elisabete Weiderpass, Marc J. Gunter, Elio Riboli

Published in: Cancer Causes & Control | Issue 7/2016

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Abstract

Background

The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC.

Methods

We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status.

Results

During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations.

Conclusion

WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine.

Impact

Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.
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Metadata
Title
Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort
Authors
Yunxia Lu
Amanda J. Cross
Neil Murphy
Heinz Freisling
Ruth C. Travis
Pietro Ferrari
Verena A. Katzke
Rudolf Kaaks
Åsa Olsson
Ingegerd Johansson
Frida Renström
Salvatore Panico
Valeria Pala
Domenico Palli
Rosario Tumino
Petra H. Peeters
Peter D. Siersema
H. B. Bueno-de-Mesquita
Antonia Trichopoulou
Eleni Klinaki
Christos Tsironis
Antonio Agudo
Carmen Navarro
María-José Sánchez
Aurelio Barricarte
Marie-Christine Boutron-Ruault
Guy Fagherazzi
Antoine Racine
Elisabete Weiderpass
Marc J. Gunter
Elio Riboli
Publication date
01-07-2016
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 7/2016
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-016-0772-z

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