Top

Published in:

01-10-2014 | Original paper

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Authors: Helen D. Bailey, Lin Fritschi, Catherine Metayer, Claire Infante-Rivard, Corrado Magnani, Eleni Petridou, Eve Roman, Logan G. Spector, Peter Kaatsch, Jacqueline Clavel, Elizabeth Milne, John D. Dockerty, Deborah C. Glass, Tracy Lightfoot, Lucia Miligi, Jérémie Rudant, Margarita Baka, Roberto Rondelli, Alicia Amigou, Jill Simpson, Alice Y. Kang, Maria Moschovi, Joachim Schüz

Published in: Cancer Causes & Control | Issue 10/2014

Abstract

Purpose

It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.

Methods

We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.

Results

Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.

Conclusions

Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.

Available only for authorised users

McNally RJ, Parker L (2006) Environmental factors and childhood acute leukemias and lymphomas. Leuk Lymphoma 47:583–598PubMedCrossRef

Gruhn B, Taub JW, Ge Y et al (2008) Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy. Leukemia 22:1692–1697PubMedCrossRef

Eguchi-Ishimae M, Eguchi M, Kempski H, Greaves M (2008) NOTCH1 mutation can be an early, prenatal genetic event in T-ALL. Blood 111:376–378PubMedCrossRef

McHale CM, Wiemels JL, Zhang L et al (2003) Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16). Blood 101:4640–4641PubMedCrossRef

Metayer C, Milne E, Clavel J et al (2013) The Childhood Leukemia International Consortium. Cancer Epidemiol 37:336–347PubMedCentralPubMedCrossRef

Schuz J, Kaletsch U, Meinert R, Kaatsch P, Michaelis J (2000) Risk of childhood leukemia and parental self-reported occupational exposure to chemicals, dusts, and fumes: results from pooled analyses of German population-based case–control studies. Cancer Epidemiol Biomark Prev 9:835–838

Shu XO, Stewart P, Wen WQ et al (1999) Parental occupational exposure to hydrocarbons and risk of acute lymphocytic leukemia in offspring. Cancer Epidemiol Biomark Prev 8:783–791

Buckley JD, Robison LL, Swotinsky R et al (1989) Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. Cancer Res 49:4030–4037PubMed

Keegan TJ, Bunch KJ, Vincent TJ et al (2012) Case–control study of paternal occupation and childhood leukaemia in Great Britain, 1962–2006. Br J Cancer 107:1652–1659PubMedCentralPubMedCrossRef

10.

McKinney PA, Fear NT, Stockton D (2003) Parental occupation at periconception: findings from the United Kingdom Childhood Cancer Study. Occup Environ Med 60:901–909PubMedCentralPubMedCrossRef

11.

Reid A, Glass DC, Bailey HD et al (2011) Parental occupational exposure to exhausts, solvents, glues and paints, and risk of childhood leukemia. Cancer Causes Control 22:1575–1585PubMedCrossRef

12.

Freedman DM, Stewart P, Kleinerman RA et al (2001) Household solvent exposures and childhood acute lymphoblastic leukemia. Am J Public Health 91:564–567PubMedCentralPubMedCrossRef

13.

Scelo G, Metayer C, Zhang L et al (2009) Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117:133–139PubMedCentralPubMedCrossRef

14.

International Agency for Research on Cancer (2010) Painting, firefighting, and shiftwork. International Agency for Research on Cancer

15.

International Agency for Research on Cancer (2009) Occupational exposure as a painter. Part F: a review of human carcinogens: chemical agents and related occupations. International Agency for Research on Cancer, Lyon

16.

Infante-Rivard C, Siemiatycki J, Lakhani R, Nadon L (2005) Maternal exposure to occupational solvents and childhood leukemia. Environ Health Perspect 113:787–792PubMedCentralPubMedCrossRef

17.

Siemiatycki J, Day NE, Fabry J, Cooper JA (1981) Discovering carcinogens in the occupational environment: a novel epidemiologic approach. J Natl Cancer Inst 66:217–225PubMed

18.

International Labour Office (2012) ISCO 08 international standard classification of occupation, vol 1. International Labour Office, Geneva

19.

Department of Manpower and Immigration (1971) Canadian classification and dictionary of occupations 1971, volume 1: classifications and definitions. Information Canada, Ottawa

20.

International Labour Office (2013) Correspondence table ISCO-08 to ISCO-88

21.

International Labour Office (1990) ISCO-88 international standard classification of occupations. International Labour Office, Geneva

22.

Federal Statistical Office Germany (1992) Klassifikation de Berufe-Kld-92-mit der Signierung für den Mikrozenus in Verbindung mit dem Umsteigerschüssel für die Internationale Standardklassifikation der berufe zur Anwendung in der Europäischen Gemeinschaft—ISCO COM. Wiesbaden

23.

Classifications and Harmonisation Unit Office for National Statistics (UK) (1990) OOSS user guide 1990:01.2 mapping of standard occupational classification 1990 (SOC 1990) to International Standard Classification of Occupations European Community version (ISCO-88 Com)

24.

Anonymous (2012) The National Crosswalk Service Center (NCSC). In: National Crosswalk Service Center, ed

25.

Brookmeyer R, Liang KY, Linet M (1986) Matched case–control designs and overmatched analyses. Am J Epidemiol 124:693–701PubMed

26.

Smith A, Lightfoot T, Simpson J, Roman E (2009) Birth weight, sex and childhood cancer: a report from the United Kingdom Childhood Cancer Study. Cancer Epidemiol 33:363–367PubMedCrossRef

27.

Hug K, Grize L, Seidler A, Kaatsch P, Schuz J (2010) Parental occupational exposure to extremely low frequency magnetic fields and childhood cancer: a German case–control study. Am J Epidemiol 171:27–35PubMedCrossRef

28.

Dockerty JD, Skegg DCG, Elwood JM, Herbison GP, Becroft DMO, Lewis ME (1999) Infections, vaccinations, and the risk of childhood leukaemia. Br J Cancer 80:1483–1489PubMedCentralPubMedCrossRef

29.

Miligi L, Benvenuti A, Mattioli S et al (2013) Risk of childhood leukaemia and non-Hodgkin’s lymphoma after parental occupational exposure to solvents and other agents: the SETIL study. Occup Environ Med 70:648–655PubMedCrossRef

30.

Riley RD, Higgins JP, Deeks JJ (2011) Interpretation of random effects meta-analyses. Br Med J 342:d549CrossRef

31.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Br Med J 327:557–560CrossRef

32.

Tibbetts J (2002) Under construction: building a safer industry. Environ Health Perspect 110:A134–A141PubMedCentralPubMedCrossRef

33.

Anonymous (2005) The volatile organic compounds in paints, varnishes and vehicle refinishing products regulations, United Kingdom [Statute on Internet]

34.

van Steensel-Moll HA, Valkenburg HA, van Zanen GE (1985) Childhood leukemia and parental occupation. A register-based case–control study. Am J Epidemiol 121:216–224PubMed

35.

Lowengart RA, Peters JM, Cicioni C et al (1987) Childhood leukemia and parents’ occupational and home exposures. J Natl Cancer Inst 79:39–46PubMed

36.

Schuz J, Spector LG, Ross JA (2003) Bias in studies of parental self-reported occupational exposure and childhood cancer. Am J Epidemiol 158:710–716PubMedCrossRef

37.

Wacholder S, McLaughlin JK, Silverman DT, Mandel JS (1992) Selection of controls in case–control studies. 1. Principles. Am J Epidemiol 135:1019–1028PubMed

38.

Raw GJ, Coward SK, Brown VM, Crump DR (2004) Exposure to air pollutants in English homes. J Expo Anal Environ Epidemiol 14(Suppl 1):S85–S94PubMedCrossRef

39.

Sorensen M, Andersen AMN, Raaschou-Nielsen O (2010) Non-occupational exposure to paint fumes during pregnancy and fetal growth in a general population. Environ Res 110:383–387PubMedCrossRef

Title: Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium
Authors: Helen D. Bailey
Lin Fritschi
Catherine Metayer
Claire Infante-Rivard
Corrado Magnani
Eleni Petridou
Eve Roman
Logan G. Spector
Peter Kaatsch
Jacqueline Clavel
Elizabeth Milne
John D. Dockerty
Deborah C. Glass
Tracy Lightfoot
Lucia Miligi
Jérémie Rudant
Margarita Baka
Roberto Rondelli
Alicia Amigou
Jill Simpson
Alice Y. Kang
Maria Moschovi
Joachim Schüz
Publication date: 01-10-2014
Publisher: Springer International Publishing
Published in: Cancer Causes & Control / Issue 10/2014
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-014-0441-z

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 10/2014

C-reactive protein, interleukin-6 and the risk of colorectal cancer: a meta-analysis

Birthweight, early life body size and adult mammographic density: a review of epidemiologic studies

Breast screening: an obsessive compulsive disorder

Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

Trends in incidence, mortality, and survival for kidney cancer in Canada, 1986–2007

Mortality from lymphohematopoietic neoplasms and other causes in a cohort of laminated plastic workers exposed to formaldehyde

Keynote webinar | Spotlight on antibody–drug conjugates in cancer