Published in:
Open Access 01-04-2014 | Original paper
Bilateral symmetry of breast tissue composition by magnetic resonance in young women and adults
Published in: Cancer Causes & Control | Issue 4/2014
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Background
Some reports suggest that there is a slightly higher frequency of breast cancer in the left breast compared with the right in middle-aged women. The reasons for this association are unknown. The water and fat content of both breasts was compared using magnetic resonance (MR). Breast water by MR reflects fibro-glandular tissue and is strongly positively correlated with percent mammographic density, a strong risk factor for breast cancer.
Methods
Magnetic resonance was used to measure fat and water content of the breast in 400 young women aged 15–30 years and a random sample of 100 of their mothers. All MR examinations were carried out using a 1.5T MR system, and 45 contiguous slices were obtained in the sagittal plane. One reader identified the breast tissue in the image, and subsequently, fat and water content was calculated using a three-point Dixon technique. Left- and right-sided images were read independently in random order.
Results
In young women, mean percent water was on average 0.84 % higher in the right compared with the left breast (p < 0.001) and total breast water was on average 6.42 cm3 greater on the right side (p < 0.001). In mothers, there were no significant differences in any breast measure between right and left sides.
Conclusion
The small differences in breast tissue composition in young women are unlikely to be associated with large differences in breast cancer risk between sides. The reported excess of left-sided breast cancer in older women is unlikely to be explained by differences in breast tissue composition.