Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Cancer Causes & Control
Published in: Cancer Causes & Control 4/2013

01-04-2013 | Original paper

The 2011–2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Authors: Ruth E. Patterson, Graham A. Colditz, Frank B. Hu, Kathryn H. Schmitz, Rexford S. Ahima, Ross C. Brownson, Kenneth R. Carson, Jorge E. Chavarro, Lewis A. Chodosh, Sarah Gehlert, Jeff Gill, Karen Glanz, Debra Haire-Joshu, Karen Louise Herbst, Christine M. Hoehner, Peter S. Hovmand, Melinda L. Irwin, Linda A. Jacobs, Aimee S. James, Lee W. Jones, Jacqueline Kerr, Adam S. Kibel, Irena B. King, Jennifer A. Ligibel, Jeffrey A. Meyerhardt, Loki Natarajan, Marian L. Neuhouser, Jerrold M. Olefsky, Enola K. Proctor, Susan Redline, Cheryl L. Rock, Bernard Rosner, David B. Sarwer, J. Sanford Schwartz, Dorothy D. Sears, Howard D. Sesso, Meir J. Stampfer, S. V. Subramanian, Elsie M. Taveras, Julia Tchou, Beti Thompson, Andrea B. Troxel, Marianne Wessling-Resnick, Kathleen Y. Wolin, Mark D. Thornquist

Published in: Cancer Causes & Control | Issue 4/2013

Login to get access

Abstract

Purpose

Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms.

Methods

The National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011–2016 TREC Collaborative Network and the 15 research projects being conducted at the centers.

Results

Four academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes three animal studies, three cohort studies, four randomized clinical trials, one cross-sectional study, and two modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality.

Conclusion

The NIH Science of Team Science group will evaluate the value added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk of cancer as well as cancer survivors.
Literature
1.
Flegal KM, Carroll MD, Kit BK, Ogden CL (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA 307:91–97CrossRef
2.
Ogden CL, Carroll MD, Kit BK, Flegal KM (2012) Prevalence of obesity and trends in the distribution of body mass index among US children and adolescents. JAMA 307:83–90CrossRef
3.
Finkelstein EA, Trogdon JG, Cohen JW, Dietz W (2009) Annual medical spending attributable to obesity: payer-and service-specific estimates. Health Aff (Millwood) 28(5):w822–w831CrossRef
4.
Basen-Engquist K, Chang M (2011) Obesity and cancer risk: recent review and evidence. Curr Oncol Rep 13:71–76PubMedCrossRef
5.
6.
Pan SY, DesMeules M (2009) Energy intake, physical activity, energy balance, and cancer: epidemiologic evidence. Methods Mol Biol 472:191–215PubMedCrossRef
7.
Bianchini F, Kaaks R, Vainio H (2002) Overweight, obesity, and cancer risk. Lancet Oncol 3:565–574PubMedCrossRef
8.
Winzer BM, Whiteman DC, Reeves MM, Paratz JD (2011) Physical activity and cancer prevention: a systematic review of clinical trials. Cancer Causes Control 22:811–826PubMedCrossRef
9.
Davies NJ, Batehup L, Thomas R (2011) The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature. Br J Cancer 1:S52–S73CrossRef
10.
Friedenreich CM, Neilson HK, Lynch BM (2010) State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer 46:2593–2604PubMedCrossRef
11.
Ballard-Barbash R, Hunsberger S, Alciati MH et al (2009) Physical activity, weight control, and breast cancer risk and survival: clinical trial rationale and design considerations. J Natl Cancer Inst 101:630–643PubMedCrossRef
12.
Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH (2010) An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surv 4:87–100CrossRef
13.
Patterson RE, Cadmus LA, Emond JA, Pierce JP (2010) Physical activity, diet, adiposity and breast cancer prognosis: a review of the epidemiologic literature. Maturitas 66:5–15PubMedCrossRef
14.
Schmitz KH, Courneya KS, Matthews C et al (2010) American college of sports medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409–1426PubMedCrossRef
15.
Jones LW, Demark-Wahnefried W (2006) Diet, exercise, and complementary therapies after primary treatment for cancer. Lancet Oncol 7:1017–1026PubMedCrossRef
16.
Hewitt M, Greenfield S, Stovall E (2006) From cancer patient to cancer survivor: lost in transition. The National Academies Press, Washington
17.
Harvey AE, Lashinger LM, Hursting SD (2011) The growing challenge of obesity and cancer: an inflammatory issue. Ann NY Acad Sci 1229:45–52PubMedCrossRef
18.
Gallagher EJ, Fierz Y, Ferguson RD, LeRoith D (2010) The pathway from diabetes and obesity to cancer, on the route to targeted therapy. Endocr Pract 16:864–873PubMedCrossRef
19.
Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301–316PubMedCrossRef
20.
Tsugane S, Inoue M (2010) Insulin resistance and cancer: epidemiological evidence. Cancer Sci 101:1073–1079PubMedCrossRef
21.
Lynch BM, Neilson HK, Friedenreich CM (2011) Physical activity and breast cancer prevention. Recent Results Cancer Res 186:13–42PubMedCrossRef
22.
Stokols D, Hall KL, Taylor BK, Moser RP (2008) The science of team science. Overview of the field and introduction to the supplement. Am J Prev Med 35:S77–S89PubMedCrossRef
23.
Croyle RT (2008) The National Cancer Institute’s transdisciplinary centers initiatives and the need for building a science of team science. Am J Prev Med 35:S90–S93PubMedCrossRef
24.
Warnecke RB, Oh A, Breen N, Gehlert S, Paskett E, Tucker KL, Lurie N, Rebbeck T, Goodwin J, Flack J, Srinivasan S, Kerner J, Heurtin-Roberts S, Abeles R, Tyson FL, Patmios G, Hiatt RA (2008) Approaching health disparities from a population perspective: the National Institutes of Health Centers for population health and health disparities. Am J Public Health 98(9):1608–1615PubMedCrossRef
25.
Abrams DB, Leslie F, Mermelstein R, Kobus K, Clayton RR (2003) Transdisciplinary tobacco use research. Nicotine Tob Res 5(Suppl 1):S5–S10PubMedCrossRef
26.
Hall KL, Stokols D, Stipelman BA, Vogel AL, Feng A, Masimore B, Morgan G, Moser RP, Marcus SE, Berrigan D (2012) Assessing the value of team science: a study comparing center- and investigator-initiated grants. Am J Prev Med 42(2):157–163PubMedCrossRef
27.
Rimer BK, Abrams DB (2012) Present and future horizons for transdisciplinary research. Am J Prev Med 42(2):200–201PubMedCrossRef
28.
Vogel AL, Feng A, Oh A, Hall KL, Stipelman B, Okamoto J, Stokols D, Moser RP, Perna F, Nebeling L (2012) Influences of a National Cancer Institute transdisciplinary research and training initiative on trainees’ transdisciplinary research competencies and scholarly productivity. Transl Behav Med 4(2):459–468
29.
Stokols D, Hall KL, Vogel AL (2012) Transdisciplinary public health: definitions, core characteristics, and strategies for success. In: Haire-Joshu D, McBride TD (eds) Transdisciplinary public health: research, methods, and practice. Jossey-Bass, San Francisco
30.
Hall KL, Stokols D, Moser RP et al (2008) The collaborative readiness of transdisciplinary research teams and centers. Findings from the National Cancer Institute’s TREC year-one evaluation study. Am J Prev Med 35:S161–S172PubMedCrossRef
31.
Neuhouser ML, Schwartz Y, Wang C, Breymeyer K, Coronado G, Wang CY, Noar K, Song X, Lampe JW (2012) A low-glycemic load diet reduces serum C-reactive protein and modestly increases adiponectin in overweight and obese adults. J Nutr 142(2):369–374PubMedCrossRef
32.
Behan JW, Yun JP, Proektor MP, Ehsanipour EA, Arutyunyan A, Moses AS, Avramis VI, Louie SG, Butturini A, Heisterkamp N, Mittelman SD (2009) Adipocytes impair leukemia treatment in mice. Cancer Res 19:7867–7874CrossRef
33.
Campbell PT, Gross MD, Potter JD, Schmitz KH, Duggan C, McTiernan A, Ulrich CM (2010) Effect of exercise on oxidative stress: a 12-month randomized, controlled trial. Med Sci Sports Exerc 42(8):1448–1453PubMedCrossRef
34.
Thompson CL, Larkin EK, Patel S, Berger NA, Redline S, Li L (2011) Short duration of sleep increases risk of colorectal adenoma. Cancer 117(4):841–847PubMedCrossRef
35.
Arikawa AY, O’Dougherty M, Kaufman B, Thomas W, Warren M, Kurzer M, Schmitz KH (2010) Women in steady exercise research (WISER): study design and methods. Contemp Clin Trials 31:457–465PubMedCrossRef
36.
Arikawa AY, Kurzer MS, Thomas W, Schmitz KH (2010) No effect of exercise on insulin-like growth factor (IGF)-1, insulin and glucose in young women participating in a 16-week randomized controlled trial. Cancer Epidemiol Biomark Prev 19:2987–2990CrossRef
37.
Arikawa AY, Thomas W, Schmitz KH, Kurzer MS (2011) Sixteen weeks of exercise reduces C-reactive protein levels in young women. Med Sci Sports Exerc 43:1002–1009PubMedCrossRef
38.
Smith AJ, Phipps WR, Arikawa AY, O’Dougherty M, Kaufman B, Thomas W, Schmitz KH, Kurzer MS (2011) Effects of aerobic exercise on premenopausal sex hormone levels: results of the WISER study, a randomized clinical trial in healthy, sedentary, eumenorrheic women. Cancer Epidemiol Biomark Prev 20:1098–1106CrossRef
39.
Schmitz KH, Ahmed RL, Troxel A, Cheville A, Smith R, Grant LL, Bryan CJ, Williams-Smith CT, Greene QP (2009) Weight lifting in women with breast cancer-related lymphedema. New Engl J Med 361:664–673PubMedCrossRef
40.
Schmitz KH, Ahmed RL, Troxel AB, Cheville A, Lewis-Grant L, Smith R, Bryan CJ, Williams-Smith CT, Chittams J (2010) Weight-lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA 304:2699–2705PubMedCrossRef
Metadata
Title
The 2011–2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design
Authors
Ruth E. Patterson
Graham A. Colditz
Frank B. Hu
Kathryn H. Schmitz
Rexford S. Ahima
Ross C. Brownson
Kenneth R. Carson
Jorge E. Chavarro
Lewis A. Chodosh
Sarah Gehlert
Jeff Gill
Karen Glanz
Debra Haire-Joshu
Karen Louise Herbst
Christine M. Hoehner
Peter S. Hovmand
Melinda L. Irwin
Linda A. Jacobs
Aimee S. James
Lee W. Jones
Jacqueline Kerr
Adam S. Kibel
Irena B. King
Jennifer A. Ligibel
Jeffrey A. Meyerhardt
Loki Natarajan
Marian L. Neuhouser
Jerrold M. Olefsky
Enola K. Proctor
Susan Redline
Cheryl L. Rock
Bernard Rosner
David B. Sarwer
J. Sanford Schwartz
Dorothy D. Sears
Howard D. Sesso
Meir J. Stampfer
S. V. Subramanian
Elsie M. Taveras
Julia Tchou
Beti Thompson
Andrea B. Troxel
Marianne Wessling-Resnick
Kathleen Y. Wolin
Mark D. Thornquist
Publication date
01-04-2013
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 4/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-013-0150-z

Other articles of this Issue 4/2013

Cancer Causes & Control 4/2013 Go to the issue

Original paper

Bleomycin-induced mutagen sensitivity, passive smoking, and risk of breast cancer in Chinese women: a case–control study

Review article

Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies

Original paper

Racial differences in the relationship between tobacco, alcohol, and squamous cell carcinoma of the head and neck

Original paper

Associations of serum 25-hydroxyvitamin D with overall and breast cancer–specific mortality in a multiethnic cohort of breast cancer survivors

Original paper

Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository

Brief report

Intention to quit smoking and concerns about household environmental risks: findings from the Health in Common Study in low-income housing
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits