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Cancer Causes & Control
Published in: Cancer Causes & Control 3/2013

01-03-2013 | Original paper

Case–control study of lifetime alcohol intake and prostate cancer risk

Authors: S. Elizabeth McGregor, Kerry S. Courneya, Karen A. Kopciuk, Cedomir Tosevski, Christine M. Friedenreich

Published in: Cancer Causes & Control | Issue 3/2013

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Abstract

Purpose

Alcohol consumption may be a modifiable risk factor for prostate cancer, but previous results have been inconsistent and limited by a lack of data on lifetime exposure and specific beverages. Furthermore, the effect of tumor stage and severity of disease on the association between alcohol and prostate cancer risk has not been fully investigated.

Methods

We examined the relation between both current and lifetime alcohol intake and prostate cancer risk in a population-based case–control study in Alberta, Canada with 947 cases with stage T2 and higher prostate cancer diagnosed between 1997 and 2000 and frequency matched to 1,039 controls, identified through random digit dialing. Cases were classified on cancer stage and severity into 619 non-aggressive (Stage II and Gleason score <8) and 328 aggressive cases (Stage III/IV or Gleason score ≥8). In-person interviews were completed on current and lifetime history of alcohol consumption and all other prostate cancer risk factors.

Results

Current alcohol intake did not increase prostate cancer risk but lifetime intake increased risk for both non-aggressive and aggressive cases, with an odds ratio of 1.78 (95 % CI 1.19–2.66) and 2.00 (95 % CI 1.19–3.36), respectively, for the highest intake quartile compared to non-drinkers with evidence for a linear trend. Associations with alcohol intake remained after exclusion of non-drinkers for non-aggressive prostate cancer cases. Only lifetime beer intake was significantly associated with increased risk, however, intakes of liquor and wine by participants were low.

Conclusions

Results support the evidence for an increased risk of prostate cancer from lifetime alcohol consumption.
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Metadata
Title
Case–control study of lifetime alcohol intake and prostate cancer risk
Authors
S. Elizabeth McGregor
Kerry S. Courneya
Karen A. Kopciuk
Cedomir Tosevski
Christine M. Friedenreich
Publication date
01-03-2013
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 3/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-012-0131-7

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