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Cancer Causes & Control
Published in: Cancer Causes & Control 12/2010

01-12-2010 | Original paper

Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis

Authors: Janneke A. Wilschut, J. Dik F. Habbema, Scott D. Ramsey, Rob Boer, Caspar W. N. Looman, Marjolein van Ballegooijen

Published in: Cancer Causes & Control | Issue 12/2010

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Abstract

Objective

It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.

Methods

We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of families with a known genetic disorder.

Results

Thirteen colonoscopy studies were identified. The adenoma prevalence was significantly higher in individuals with a family history than in those without (OR 1.7, 95% CI 1.4–3.5). The adenoma prevalence increased with age (OR per year of age 1.06, 95% CI 1.05–1.07). The age trend did not differ significantly between the two groups.

Conclusion

Individuals with a family history of colorectal cancer have a considerably higher prevalence of adenomas compared to individuals without a family history. This is consistent with their increased risk of colorectal cancer.
Appendix
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Metadata
Title
Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis
Authors
Janneke A. Wilschut
J. Dik F. Habbema
Scott D. Ramsey
Rob Boer
Caspar W. N. Looman
Marjolein van Ballegooijen
Publication date
01-12-2010
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 12/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9654-y

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