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01-05-2010 | Original paper

Human papillomavirus is not associated with colorectal cancer in a large international study

Authors: Michele C. Gornick, Xavier Castellsague, Gloria Sanchez, Thomas J. Giordano, Michelle Vinco, Joel K. Greenson, Gabriel Capella, Leon Raskin, Gad Rennert, Stephen B. Gruber, Victor Moreno

Published in: Cancer Causes & Control | Issue 5/2010

Abstract

Objective of the study

Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer.

Methods

The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15).

Results

All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method.

Conclusions

We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

Bosch FX, de Sanjose S (2002) Human papillomavirus in cervical cancer. Curr Oncol Rep 4(2):175–183CrossRefPubMed

Schiffman MH, Bauer HM, Hoover RN, Glass AG, Cadell DM, Rush BB et al (1993) Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst 85(12):958–964CrossRefPubMed

zur Hausen H (1996) Papillomavirus infections—a major cause of human cancers. Biochim Biophys Acta 1288(2):F55–F78PubMed

Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV et al (2003) Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348(6):518–527CrossRefPubMed

Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189(1):12–19CrossRefPubMed

Schlecht NF, Kulaga S, Robitaille J, Ferreira S, Santos M, Miyamura RA et al (2001) Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA 286(24):3106–3114CrossRefPubMed

Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S (2007) Human papillomavirus and cervical cancer. Lancet 370(9590):890–907CrossRefPubMed

Madeleine MM, Daling JR, Carter JJ, Wipf GC, Schwartz SM, McKnight B et al (1997) Cofactors with human papillomavirus in a population-based study of vulvar cancer. J Natl Cancer Inst 89(20):1516–1523CrossRefPubMed

Goffin F, Mayrand MH, Gauthier P, Alobaid A, Lussier C, Provencher D et al (2006) High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia. J Med Virol 78(6):814–819CrossRefPubMed

10.

Madsen BS, Jensen HL, van den Brule AJ, Wohlfahrt J, Frisch M (2008) Risk factors for invasive squamous cell carcinoma of the vulva and vagina—population-based case-control study in Denmark. Int J Cancer 122(12):2827–2834CrossRefPubMed

11.

Daling JR, Madeleine MM, Schwartz SM, Shera KA, Carter JJ, McKnight B et al (2002) A population-based study of squamous cell vaginal cancer: HPV and cofactors. Gynecol Oncol 84(2):263–270CrossRefPubMed

12.

Daling JR, Sherman KJ (1992) Relationship between human papillomavirus infection and tumours of anogenital sites other than the cervix. IARC Sci Publ 119:223–241PubMed

13.

Frisch M, Glimelius B, van den Brule AJ, Wohlfahrt J, Meijer CJ, Walboomers JM et al (1997) Sexually transmitted infection as a cause of anal cancer. N Engl J Med 337(19):1350–1358CrossRefPubMed

14.

Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA et al (2004) Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 101(2):270–280CrossRefPubMed

15.

Bjorge T, Engeland A, Luostarinen T, Mork J, Gislefoss RE, Jellum E et al (2002) Human papillomavirus infection as a risk factor for anal and perianal skin cancer in a prospective study. Br J Cancer 87(1):61–64CrossRefPubMed

16.

Tornesello ML, Duraturo ML, Losito S, Botti G, Pilotti S, Stefanon B et al (2008) Human papillomavirus genotypes and HPV16 variants in penile carcinoma. Int J Cancer 122(1):132–137CrossRefPubMed

17.

Heideman DA, Waterboer T, Pawlita M, Delis-van Diemen P, Nindl I, Leijte JA et al (2007) Human papillomavirus-16 is the predominant type etiologically involved in penile squamous cell carcinoma. J Clin Oncol 25(29):4550–4556CrossRefPubMed

18.

Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA et al (2005) Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer 116(4):606–616CrossRefPubMed

19.

Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG et al (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159(4):1211–1218PubMed

20.

Iwasawa A, Kumamoto Y, Fujinaga K (1993) Detection of human papillomavirus deoxyribonucleic acid in penile carcinoma by polymerase chain reaction and in situ hybridization. J Urol 149(1):59–63PubMed

21.

Ritchie JM, Smith EM, Summersgill KF, Hoffman HT, Wang D, Klussmann JP et al (2003) Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 104(3):336–344CrossRefPubMed

22.

Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92(9):709–720CrossRefPubMed

23.

Ringstrom E, Peters E, Hasegawa M, Posner M, Liu M, Kelsey KT (2002) Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res 8(10):3187–3192PubMed

24.

Torrente MC, Ampuero S, Abud M, Ojeda JM (2005) Molecular detection and typing of human papillomavirus in laryngeal carcinoma specimens. Acta Otolaryngol 125(8):888–893PubMed

25.

Almadori G, Cadoni G, Cattani P, Posteraro P, Scarano E, Ottaviani F et al (1996) Detection of human papillomavirus DNA in laryngeal squamous cell carcinoma by polymerase chain reaction. Eur J Cancer 32A(5):783–788CrossRefPubMed

26.

Manjarrez ME, Ocadiz R, Valle L, Pacheco C, Marroquin A, De la Torre C et al (2006) Detection of human papillomavirus and relevant tumor suppressors and oncoproteins in laryngeal tumors. Clin Cancer Res 12(23):6946–6951CrossRefPubMed

27.

Brandwein MS, Nuovo GJ, Biller H (1993) Analysis of prevalence of human papillomavirus in laryngeal carcinomas. Study of 40 cases using polymerase chain reaction and consensus primers. Ann Otol Rhinol Laryngol 102(4 Pt 1):309–313PubMed

28.

Perez LO, Abba MC, Laguens RM, Golijow CD (2005) Analysis of adenocarcinoma of the colon and rectum: detection of human papillomavirus (HPV) DNA by polymerase chain reaction. Colorectal Dis 7(5):492–495CrossRefPubMed

29.

Bodaghi S, Yamanegi K, Xiao SY, Da Costa M, Palefsky JM, Zheng ZM (2005) Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res 11(8):2862–2867CrossRefPubMed

30.

Buyru N, Tezol A, Dalay N (2006) Coexistence of K-ras mutations and HPV infection in colon cancer. BMC Cancer 6:115CrossRefPubMed

31.

Damin DC, Caetano MB, Rosito MA, Schwartsmann G, Damin AS, Frazzon AP et al (2007) Evidence for an association of human papillomavirus infection and colorectal cancer. Eur J Surg Oncol 33(5):569–574CrossRefPubMed

32.

Shah KV, Daniel RW, Simons JW, Vogelstein B (1992) Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction. J Surg Oncol 51(1):5–7CrossRefPubMed

33.

Shroyer KR, Kim JG, Manos MM, Greer CE, Pearlman NW, Franklin WA (1992) Papillomavirus found in anorectal squamous carcinoma, not in colon adenocarcinoma. Arch Surg 127(6):741–744PubMed

34.

de Roda Husman AM, Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ (1995) The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76(Pt 4):1057–1062CrossRefPubMed

35.

Kleter B, van Doorn LJ, ter Schegget J, Schrauwen L, van Krimpen K, Burger M et al (1998) Novel short-fragment PCR assay for highly sensitive broad-spectrum detection of anogenital human papillomaviruses. Am J Pathol 153(6):1731–1739PubMed

36.

van den Brule AJ, Pol R, Fransen-Daalmeijer N, Schouls LM, Meijer CJ, Snijders PJ (2002) GP5+/6+ PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes. J Clin Microbiol 40(3):779–787CrossRefPubMed

37.

Kleter B, van Doorn LJ, Schrauwen L, Molijn A, Sastrowijoto S, ter Schegget J et al (1999) Development and clinical evaluation of a highly sensitive PCR-reverse hybridization line probe assay for detection and identification of anogenital human papillomavirus. J Clin Microbiol 37(8):2508–2517PubMed

38.

Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS et al (2005) Statins and the risk of colorectal cancer. N Engl J Med 352(21):2184–2192CrossRefPubMed

39.

Moreno V, Gemignani F, Landi S, Gioia-Patricola L, Chabrier A, Blanco I et al (2006) Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Clin Cancer Res 12(7 Pt 1):2101–2108CrossRefPubMed

40.

Giordano TJ, Shedden KA, Schwartz DR, Kuick R, Taylor JM, Lee N et al (2001) Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol 159(4):1231–1238PubMed

41.

Jacobs MV, Snijders PJ, van den Brule AJ, Helmerhorst TJ, Meijer CJ, Walboomers JM (1997) A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol 35(3):791–795PubMed

42.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed

43.

Ades AE, Lu G, Higgins JP (2005) The interpretation of random-effects meta-analysis in decision models. Med Decis Making 25(6):646–654CrossRefPubMed

44.

Klug SJ, Molijn A, Schopp B, Holz B, Iftner A, Quint W et al (2008) Comparison of the performance of different HPV genotyping methods for detecting genital HPV types. J Med Virol 80(7):1264–1274CrossRefPubMed

Title: Human papillomavirus is not associated with colorectal cancer in a large international study
Authors: Michele C. Gornick
Xavier Castellsague
Gloria Sanchez
Thomas J. Giordano
Michelle Vinco
Joel K. Greenson
Gabriel Capella
Leon Raskin
Gad Rennert
Stephen B. Gruber
Victor Moreno
Publication date: 01-05-2010
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 5/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9502-0

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Abstract

Objective of the study

Methods

Results

Conclusions

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