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Cancer Causes & Control
Published in: Cancer Causes & Control 4/2010

01-04-2010 | Original paper

Genes involved with folate uptake and distribution and their association with colorectal cancer risk

Authors: Jane C. Figueiredo, A. Joan Levine, Won H. Lee, David V. Conti, Jenny N. Poynter, Peter T. Campbell, David Duggan, Juan Pablo Lewinger, Maria Elena Martinez, Cornelia M. Ulrich, Polly Newcomb, John Potter, Paul J. Limburg, John Hopper, Mark A. Jenkins, Loic Le Marchand, John A. Baron, Robert W. Haile

Published in: Cancer Causes & Control | Issue 4/2010

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Abstract

Folate status is an important predictor of colorectal cancer risk. Common genetic variants in genes involved in regulating cellular folate levels might also predict risk, but there are limited data on this issue. We conducted a family-based case–control association study of variants in four genes involved in folate uptake and distribution: FOLR1, FPGS, GGH and SLC19A1, using 1,750 population-based and 245 clinic-based cases of pathologically confirmed colorectal cancer and their unaffected relatives participating in the Colon Cancer Family Registries. Standardized questionnaires, administered to all participants, collected information on risk factors and diet. Standard molecular techniques were used to determine microsatellite instability (MSI) status on cases. tagSNPs (n = 29) were selected based on coverage as assessed by pairwise r 2. We found no evidence that tagSNPs in these genes were associated with risk of colorectal cancer. For the SLC19A1-rs1051266 (G80A, Arg27His) missense polymorphism, the A/A genotype was not associated with risk of colorectal cancer using population-based (OR = 1.00; 95% CI = 0.81–1.23) or clinic-based (OR = 0.75; 95% CI = 0.44–1.29) families compared to the G/A and G/G genotypes. We found no evidence that the association between any tagSNP and CRC risk was modified by multivitamin use, folic acid use and dietary folate intake and total folate intake. The odds ratios were similar, irrespective of MSI status, tumor subsite and family history of colorectal cancer. In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer.
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Metadata
Title
Genes involved with folate uptake and distribution and their association with colorectal cancer risk
Authors
Jane C. Figueiredo
A. Joan Levine
Won H. Lee
David V. Conti
Jenny N. Poynter
Peter T. Campbell
David Duggan
Juan Pablo Lewinger
Maria Elena Martinez
Cornelia M. Ulrich
Polly Newcomb
John Potter
Paul J. Limburg
John Hopper
Mark A. Jenkins
Loic Le Marchand
John A. Baron
Robert W. Haile
Publication date
01-04-2010
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 4/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-009-9489-6

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