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Cancer Causes & Control
Published in: Cancer Causes & Control 9/2009

01-11-2009 | Original paper

Meat intake, meat mutagens and risk of lung cancer in Uruguayan men

Authors: Eduardo De Stefani, Paolo Boffetta, Hugo Deneo-Pellegrini, Alvaro L. Ronco, Dagfinn Aune, Gisele Acosta, Paul Brennan, María Mendilaharsu, Gilles Ferro

Published in: Cancer Causes & Control | Issue 9/2009

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Abstract

Objective

To determine the role of meat consumption and related mutagens in the etiology of lung cancer, we conducted a case–control study among Uruguayan males in the time period 1996–2004.

Methods

The study included 846 cases and 846 controls, frequency matched on age and residence. Both series were drawn from the four major public hospitals in Montevideo, Uruguay. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) of lung cancer by quartiles of meat intake and mutagens.

Results

The highest vs. the lowest quartile of intake of total meat (OR = 2.04, 95% CI 1.42–2.92), red meat (OR = 2.33, 95% CI 1.63–3.32), and processed meat (OR = 1.79, 95% CI 1.22–2.65) was associated with increased risk of lung cancer, while intake of total white meat, poultry and fish was not. Heterocyclic amines (IQ, MeIQx, PhIP), nitrosamines and benzo[a]pyrene were directly associated with the risk of lung cancer (OR for PhIP 2.16, 95% CI 1.48–3.15). Moreover, both red meat and meat mutagens displayed higher risks among former smokers compared with current smokers.

Conclusions

This study suggests that red and processed meat and meat mutagens may play a role in the etiology of lung cancer.
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Metadata
Title
Meat intake, meat mutagens and risk of lung cancer in Uruguayan men
Authors
Eduardo De Stefani
Paolo Boffetta
Hugo Deneo-Pellegrini
Alvaro L. Ronco
Dagfinn Aune
Gisele Acosta
Paul Brennan
María Mendilaharsu
Gilles Ferro
Publication date
01-11-2009
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 9/2009
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-009-9411-2

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