Published in:
01-08-2007
Occupation and risk of lung cancer in Central and Eastern Europe: the IARC multi-center case–control study
Published in: Cancer Causes & Control | Issue 6/2007
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Objective
We sought to evaluate the role of occupation and industry in lung carcinogenesis in six countries in Central and Eastern Europe.
Methods
This multi-center case–control study included 2,056 male and 576 female lung cancer incidence cases diagnosed from 1998 to 2001 and 2,144 male and 727 female controls frequency-matched for sex and age. Unconditional regression models were applied to calculate the odds ratios after controlling for potential confounders including age (5-year groups), study center (15 centers), and tobacco pack-years.
Results
Elevated odds ratios (ORs) were found for men employed as production workers (OR 1.45, 95% CI 1.22–1.72), bookkeepers and cashiers (1.81, 1.03–3.24), general farmers (1.67, 1.08–2.60), livestock workers (2.54, 1.09–5.88), miners (2.17, 1.47–3.23), toolmakers and metal patternmakers (2.56, 1.34–4.94), glass formers (2.55, 1.18–5.50), dockworkers, and freight handlers (1.49, 1.04–2.12). Industries with elevated risk among men included mining (1.75, 1.20–2.57), manufacture of cement, lime, or plaster (3.62, 1.11–12.00), casting of metals (2.00, 1.17–3.45), manufacture of electric motors (2.18, 1.24–3.86). For women, elevated ORs were found for medical, dental, veterinary doctors (2.54, 1.01–6.31), librarians and curators (7.03, 1.80–27.80), sewers 3.63 (1.12–10.23).
Conclusions
This study identifies new areas for further, explanatory analyses, especially in production work, and indicates new possible sources of exposure to cancer risk for women.