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Cancer Causes & Control
Published in: Cancer Causes & Control 4/2007

01-05-2007 | Original Paper

Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition

Authors: Christine Friedenreich, Anne Cust, Petra H. Lahmann, Karen Steindorf, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Sylvie Mesrine, Jakob Linseisen, Sabine Rohrmann, Heiner Boeing, Tobias Pischon, Anne Tjønneland, Jytte Halkjær, Kim Overvad, Michelle Mendez, M. L. Redondo, Carmen Martinez Garcia, Nerea Larrañaga, María-José Tormo, Aurelio Barricarte Gurrea, Sheila Bingham, Kay-Tee Khaw, Naomi Allen, Tim Key, Antonia Trichopoulou, Effie Vasilopoulou, Dimitrios Trichopoulos, Valeria Pala, Domenico Palli, Rosario Tumino, Amalia Mattiello, Paolo Vineis, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Göran Berglund, Jonas Manjer, Eva Lundin, Annekatrin Lukanova, Nadia Slimani, Mazda Jenab, Rudolf Kaaks, Elio Riboli

Published in: Cancer Causes & Control | Issue 4/2007

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Abstract

Objective

To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups.

Methods

Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling.

Results

Weight, body mass index (BMI), waist and hip circumferences and waist–hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30– < 40 kg/m2) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41–2.26, and for morbidly obese women (BMI ≥ 40) was 3.02, 95% CI = 1.66–5.52. The RR for women with a waist circumference of ≥88 cm vs. <80 cm was 1.76, 95% CI = 1.42–2.19. Adult weight gain of ≥20 kg compared with stable weight (±3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11–2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users.

Conclusion

Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.
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Metadata
Title
Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition
Authors
Christine Friedenreich
Anne Cust
Petra H. Lahmann
Karen Steindorf
Marie-Christine Boutron-Ruault
Françoise Clavel-Chapelon
Sylvie Mesrine
Jakob Linseisen
Sabine Rohrmann
Heiner Boeing
Tobias Pischon
Anne Tjønneland
Jytte Halkjær
Kim Overvad
Michelle Mendez
M. L. Redondo
Carmen Martinez Garcia
Nerea Larrañaga
María-José Tormo
Aurelio Barricarte Gurrea
Sheila Bingham
Kay-Tee Khaw
Naomi Allen
Tim Key
Antonia Trichopoulou
Effie Vasilopoulou
Dimitrios Trichopoulos
Valeria Pala
Domenico Palli
Rosario Tumino
Amalia Mattiello
Paolo Vineis
H. Bas Bueno-de-Mesquita
Petra H. M. Peeters
Göran Berglund
Jonas Manjer
Eva Lundin
Annekatrin Lukanova
Nadia Slimani
Mazda Jenab
Rudolf Kaaks
Elio Riboli
Publication date
01-05-2007
Publisher
Kluwer Academic Publishers
Published in
Cancer Causes & Control / Issue 4/2007
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-006-0113-8

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