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Cancer Causes & Control

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01-12-2006 | Original Paper

Body size and composition and risk of rectal cancer (Australia)

Authors: Robert J. MacInnis, Dallas R. English, Andrew M. Haydon, John L. Hopper, Dorota M. Gertig, Graham G. Giles

Published in: Cancer Causes & Control | Issue 10/2006

Abstract

Background

Although body mass index has been shown to be associated with colon cancer, studies of rectal cancer risk have generally reported no association. The relationship between rectal cancer risk and central adiposity, overall fat mass, and fat-free mass is unknown.

Methods

In a prospective cohort study of people aged 27–75 years, body measurements were taken directly; fat mass and fat-free mass being estimated by bioelectrical impedance analysis and central adiposity by waist circumference and waist-to-hip ratio. Among 16,867 men and 24,247 women followed on average for 10.3 years, 229 rectal cancers were ascertained via the population cancer registry.

Results

When comparing the highest tertile with the lowest tertile, weight (hazard ratio = 1.4, 95% confidence interval (CI) 1.1–2.0), waist circumference (hazard ratio = 1.4, 95% CI 1.0–1.9), fat mass (hazard ratio = 1.4, 95% CI 1.0–2.0) and percent fat (hazard ratio = 1.4, 95% CI 1.0–2.0) were positively associated with rectal cancer risk. There was no evidence that risk differed by sex for any of the anthropometric measures.

Conclusions

Waist circumference and fat mass may be weakly related to risk of rectal cancer.

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Title: Body size and composition and risk of rectal cancer (Australia)
Authors: Robert J. MacInnis
Dallas R. English
Andrew M. Haydon
John L. Hopper
Dorota M. Gertig
Graham G. Giles
Publication date: 01-12-2006
Publisher: Kluwer Academic Publishers
Published in: Cancer Causes & Control / Issue 10/2006
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-006-0074-y

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Abstract

Background

Methods

Results

Conclusions

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