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Cancer Causes & Control
Published in: Cancer Causes & Control 9/2006

01-11-2006 | Original Paper

Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela

Authors: Ikuko Kato, Federico Canzian, Silvia Franceschi, Martyn Plummer, Leen-Jan van Doorn, Yanhui Lu, Lydie Gioia-Patricola, Jorge Vivas, Gladys Lopez, Richard K. Severson, Ann G. Schwartz, Nubia Muñoz

Published in: Cancer Causes & Control | Issue 9/2006

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Abstract

Objectives

The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors.

Methods

The study population consisted of 2,033 Venezuelan subjects known to have extremely high Helicobacter Pylori (HP) infection rates. The odds ratios (OR) and 95% confidence intervals (CI) associated with these polymorphisms were estimated by multinominal logistic regression models for gastric precursor lesions.

Results

We found a 60% increase in risk of intestinal metaplasia (IM) and dysplasia combined (OR 1.62, 95% CI: 1.10–2.38) among the carriers of the IL10-1082 low activity allele. This increased risk was more pronounced for dysplasia than for IM. On the other hand, homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05–2.21), compared with homozygotes of the high activity allele. There were no statistically significant synergetic interactions between these polymorphisms and environmental risk factors (low fruit intake, high starchy vegetable intake and cigarette smoking) for these lesions.

Conclusion

While the results of the present study suggest roles of genetic variability in these anti-inflammatory mediators in different stages of gastric carcinogenesis, there is high likelihood that they were chance findings due to multiple comparisons.
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Metadata
Title
Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela
Authors
Ikuko Kato
Federico Canzian
Silvia Franceschi
Martyn Plummer
Leen-Jan van Doorn
Yanhui Lu
Lydie Gioia-Patricola
Jorge Vivas
Gladys Lopez
Richard K. Severson
Ann G. Schwartz
Nubia Muñoz
Publication date
01-11-2006
Publisher
Kluwer Academic Publishers
Published in
Cancer Causes & Control / Issue 9/2006
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-006-0060-4

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