Skip to main content
Top
Published in: Cancer Causes & Control 4/2006

01-05-2006 | Original Paper

Survival Among Patients with Adenocarcinoma of the Pancreas: A Population-based Study (United States)

Authors: Rosemary D. Cress, Daixin Yin, Lisa Clarke, Richard Bold, Elizabeth A. Holly

Published in: Cancer Causes & Control | Issue 4/2006

Login to get access

Abstract

Objective

The purpose of the current study was to evaluate survival of patients diagnosed in California with adenocarcinoma of the pancreas by demographic and tumor-related factors.

Methods

Through the California Cancer Registry (CCR) we identified all California residents diagnosed with invasive pancreatic adenocarcinoma between 1994 and 2000. Demographic, tumor and treatment information was extracted from the CCR, and socioeconomic status (SES) was assigned based on census block group of residence.

Results

A total of 10,612 eligible patients were identified of whom 1674 (15.8%) underwent surgical resection. Patients of lower SES were less likely to undergo resection and somewhat less likely to survive. Median survival was 3.5 months for patients who were not resected and 13.3 months for those who underwent resection. Adjuvant therapy was associated with a decreased risk of death among patients who underwent resection.

Conclusions

This study is the largest population-based study to date to explore survival from pancreatic cancer among all age groups in a racially diverse population. Median survival was shorter than that reported from other series. Race/ethnicity did not have a significant effect on survival. However patients residing in poor neighborhoods were less likely to undergo resection and somewhat less likely to survive this disease.
Literature
1.
go back to reference Tucker T, Howe H, Weir H (1999) Certification for population-based cancer registries. J Registry Manage 26:24–27 Tucker T, Howe H, Weir H (1999) Certification for population-based cancer registries. J Registry Manage 26:24–27
2.
go back to reference Stewart S, Glaser S, Horn-Ross P, West D (1993) SEER study of methods to classify Hispanic cancer patients (Final Report: Contract N01-CN-05224). In Edition Union City, CA: Northern California Cancer Center Stewart S, Glaser S, Horn-Ross P, West D (1993) SEER study of methods to classify Hispanic cancer patients (Final Report: Contract N01-CN-05224). In Edition Union City, CA: Northern California Cancer Center
3.
go back to reference Kwong S, Perkins C, Morris C et al. (2001) Cancer in California: 1988–1999. In Edition Sacramento, CA: California Department of Health Services, Cancer Surveillance Section Kwong S, Perkins C, Morris C et al. (2001) Cancer in California: 1988–1999. In Edition Sacramento, CA: California Department of Health Services, Cancer Surveillance Section
4.
go back to reference Shambaugh E, Ries L, Young J et al. (1992) SEER Extent of Disease – 1988 Codes and Coding Instructions Shambaugh E, Ries L, Young J et al. (1992) SEER Extent of Disease – 1988 Codes and Coding Instructions
5.
go back to reference Seiffert J, ed. (1993) SEER Program: comparative staging guide for cancer, version 1.1. National Cancer Institute Seiffert J, ed. (1993) SEER Program: comparative staging guide for cancer, version 1.1. National Cancer Institute
6.
go back to reference Young J, Roffers S, Ries L et al. (2001) SEER Summary Staging Manual – 2000. Codes and Coding Instructions, National Cancer Institute, Bethesda, MD Young J, Roffers S, Ries L et al. (2001) SEER Summary Staging Manual – 2000. Codes and Coding Instructions, National Cancer Institute, Bethesda, MD
7.
go back to reference Percy C, Van Holten V, Muir C (eds) (1990) International Classification of Diseases for Oncology, 2nd Edition. Geneva: World Health Organization Percy C, Van Holten V, Muir C (eds) (1990) International Classification of Diseases for Oncology, 2nd Edition. Geneva: World Health Organization
8.
go back to reference Yost K, Perkins C, Cohen R et al. (2001) Socioeconomic status and breast cancer incidence in California for different race/ethnic groups. Cancer Causes Control 12:703–711CrossRefPubMed Yost K, Perkins C, Cohen R et al. (2001) Socioeconomic status and breast cancer incidence in California for different race/ethnic groups. Cancer Causes Control 12:703–711CrossRefPubMed
9.
go back to reference Kaplan E, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481 Kaplan E, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481
10.
go back to reference Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163–170PubMed Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163–170PubMed
11.
go back to reference Cox D (1972) Regression models and life tables. J R Stat Soc 34:187–202 Cox D (1972) Regression models and life tables. J R Stat Soc 34:187–202
12.
go back to reference Lim JE, Chien MW, Earle CC (2003) Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg 237:74–85PubMed Lim JE, Chien MW, Earle CC (2003) Prognostic factors following curative resection for pancreatic adenocarcinoma: a population-based, linked database analysis of 396 patients. Ann Surg 237:74–85PubMed
13.
go back to reference Nattinger AB, McAuliffe TL, Schapira MM (1997) Generalizability of the surveillance, epidemiology, and end results registry population: factors relevant to epidemiologic and health care research. J Clin Epidemiol 50:939–945CrossRefPubMed Nattinger AB, McAuliffe TL, Schapira MM (1997) Generalizability of the surveillance, epidemiology, and end results registry population: factors relevant to epidemiologic and health care research. J Clin Epidemiol 50:939–945CrossRefPubMed
14.
go back to reference Warren JL, Klabunde CN, Schrag D et al. (2002) Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Med Care 40:IV-3-18 Warren JL, Klabunde CN, Schrag D et al. (2002) Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population. Med Care 40:IV-3-18
15.
go back to reference Tsiotos GG, Farnell MB, Sarr MG (1999) Are the results of pancreatectomy for pancreatic cancer improving? World J Surg 23:913–919CrossRefPubMed Tsiotos GG, Farnell MB, Sarr MG (1999) Are the results of pancreatectomy for pancreatic cancer improving? World J Surg 23:913–919CrossRefPubMed
16.
go back to reference Bachmann MO, Alderson D, Peters TJ et al. (2003) Influence of specialization on the management and outcome of patients with pancreatic cancer. Br J Surg 90:171–177CrossRefPubMed Bachmann MO, Alderson D, Peters TJ et al. (2003) Influence of specialization on the management and outcome of patients with pancreatic cancer. Br J Surg 90:171–177CrossRefPubMed
17.
go back to reference Niederhuber JE, Brennan MF, Menck HR (1995) The National Cancer Data Base report on pancreatic cancer. Cancer 76:1671–1677PubMed Niederhuber JE, Brennan MF, Menck HR (1995) The National Cancer Data Base report on pancreatic cancer. Cancer 76:1671–1677PubMed
18.
go back to reference Nitecki SS, Sarr MG, Colby TV, van Heerden JA (1995) Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann Surg 221:59–66PubMed Nitecki SS, Sarr MG, Colby TV, van Heerden JA (1995) Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann Surg 221:59–66PubMed
19.
go back to reference Gudjonsson B (2002) Survival statistics gone awry: pancreatic cancer, a case in point. J Clin Gastroenterol 35:180–184CrossRefPubMed Gudjonsson B (2002) Survival statistics gone awry: pancreatic cancer, a case in point. J Clin Gastroenterol 35:180–184CrossRefPubMed
20.
go back to reference Conlon KC, Klimstra DS, Brennan MF (1996) Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 223:273–279PubMed Conlon KC, Klimstra DS, Brennan MF (1996) Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 223:273–279PubMed
21.
go back to reference Kuhlmann KF, de Castro SM, Wesseling JG et al. (2004) Surgical treatment of pancreatic adenocarcinoma; actual survival and prognostic factors in 343 patients. Eur J Cancer 40:549–558CrossRefPubMed Kuhlmann KF, de Castro SM, Wesseling JG et al. (2004) Surgical treatment of pancreatic adenocarcinoma; actual survival and prognostic factors in 343 patients. Eur J Cancer 40:549–558CrossRefPubMed
22.
go back to reference Cleary SP, Gryfe R, Guindi M et al. (2004) Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg 198:722–731CrossRefPubMed Cleary SP, Gryfe R, Guindi M et al. (2004) Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg 198:722–731CrossRefPubMed
23.
go back to reference Choti MA (2004) Adjuvant therapy for pancreatic cancer–the debate continues. N Engl J Med 350:1249–1251CrossRefPubMed Choti MA (2004) Adjuvant therapy for pancreatic cancer–the debate continues. N Engl J Med 350:1249–1251CrossRefPubMed
24.
go back to reference Cress RD, Zaslavsky AM, West DW et al. (2003) Completeness of information on adjuvant therapies for colorectal cancer in population-based cancer registries. Med Care 41:1006–1012PubMed Cress RD, Zaslavsky AM, West DW et al. (2003) Completeness of information on adjuvant therapies for colorectal cancer in population-based cancer registries. Med Care 41:1006–1012PubMed
25.
go back to reference Yeo CJ, Abrams RA, Grochow LB et al. (1997) Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg 225:621–633; discussion 633–626CrossRefPubMed Yeo CJ, Abrams RA, Grochow LB et al. (1997) Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival. A prospective, single-institution experience. Ann Surg 225:621–633; discussion 633–626CrossRefPubMed
26.
go back to reference Sohn TA, Yeo CJ, Cameron JL et al. (2000) Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 4:567–579PubMed Sohn TA, Yeo CJ, Cameron JL et al. (2000) Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 4:567–579PubMed
Metadata
Title
Survival Among Patients with Adenocarcinoma of the Pancreas: A Population-based Study (United States)
Authors
Rosemary D. Cress
Daixin Yin
Lisa Clarke
Richard Bold
Elizabeth A. Holly
Publication date
01-05-2006
Publisher
Kluwer Academic Publishers
Published in
Cancer Causes & Control / Issue 4/2006
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-005-0539-4

Other articles of this Issue 4/2006

Cancer Causes & Control 4/2006 Go to the issue

Special Section on Cancer and Rhythm

Electromagnetic Fields and Female Breast Cancer

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine