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Cancer Causes & Control
Published in: Cancer Causes & Control 2/2006

01-03-2006 | Original Paper

Incidence and Characteristics of Childhood Hodgkin’s Lymphoma in Greece: A Nationwide Study (Greece)

Authors: E. Petridou, E. Andrie, N. Dessypris, S. K. Dikalioti, D. Trichopoulos, The Childhood Hematology–Oncology Group

Published in: Cancer Causes & Control | Issue 2/2006

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Abstract

Objectives To estimate the incidence and epidemiological profile of childhood (0–14 years) Hodgkin’s lymphoma in Greece derived by the network of childhood Hematology–Oncology departments on the basis of all 95 newly diagnosed cases during a seven-year period.
Methods Seventy-one of these cases were individually age and gender matched to an equal number of controls.
Results The incidence of childhood Hodgkin Lymphoma reached a relatively high figure of 7.8 per million children-years, with an age distribution (2.2 for children 0–4; 6.3 for those 5–9 and 13.9 for those 10–14-years-old) and male to female ratio (1.7:1) similar to that reported from other cancer registries. Childhood Hodgkin’s lymphoma was more common among children living in less crowded quarters (odds ratio (OR): 6.5 and 95% confidence intervals (95% CI): 1.4–30.7), among those who have changed residence 60 to 18 months before the onset of the index disease (OR: 4.4, and 95% CI = 1.4–14.0), among those whose families owned a cat (OR: 5.5, 95% CI = 1.2–25.6) but not among those whose families owned a dog and marginally more common, among those with a history of infectious mononucleosis (OR: 5.0, 95% CI = 0.6–42.8).
Conclusions Our results point to infectious agent(s) as playing an etiological role but do not allow discrimination among the delayed establishment of the herd immunity hypothesis, the population mixing hypothesis or that invoking transmission of the agent(s) from the non-human reservoir.
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Metadata
Title
Incidence and Characteristics of Childhood Hodgkin’s Lymphoma in Greece: A Nationwide Study (Greece)
Authors
E. Petridou
E. Andrie
N. Dessypris
S. K. Dikalioti
D. Trichopoulos
The Childhood Hematology–Oncology Group
Publication date
01-03-2006
Publisher
Kluwer Academic Publishers
Published in
Cancer Causes & Control / Issue 2/2006
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-005-0409-0

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