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01-03-2006 | Original Paper

Dietary Phytoestrogen, Serum Enterolactone and Risk of Prostate Cancer: The Cancer Prostate Sweden Study (Sweden)

Authors: Maria Hedelin, Åsa Klint, Ellen T. Chang, Rino Bellocco, Jan-Erik Johansson, Swen-Olof Andersson, Satu-Maarit Heinonen, Herman Adlercreutz, Hans-Olov Adami, Henrik Grönberg, Katarina Augustsson Bälter

Published in: Cancer Causes & Control | Issue 2/2006

Abstract

Objective

Based on evidence that phytoestrogens may protect against prostate cancer, we evaluated the associations between serum enterolactone concentration or dietary phytoestrogen intake and risk of prostate cancer.

Methods

In our Swedish population-based case-control study, questionnaire-data were available for 1,499 prostate cancer cases and 1,130 controls, with serum enterolactone levels in a sub-group of 209 cases and 214 controls. Unconditional logistic regression was performed to estimate multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for associations with risk of prostate cancer.

Results

High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The OR comparing the highest to the lowest quartile of intake was 0.74 (95% CI: 0.57–0.95; p-value for trend: 0.01). In contrast, we found no association between dietary intake of total or individual lignans or isoflavonoids and risk of prostate cancer. Intermediate serum levels of enterolactone were associated with a decreased risk of prostate cancer. The ORs comparing increasing quartiles of serum enterolactone concentration to the lowest quartile were, respectively, 0.28 (95% CI: 0.15–0.55), 0.63 (95% CI: 0.35–1.14) and 0.74 (95% CI: 0.41–1.32).

Conclusions

Our results support the hypothesis that certain foods high in phytoestrogens are associated with a lower risk of prostate cancer.

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Title: Dietary Phytoestrogen, Serum Enterolactone and Risk of Prostate Cancer: The Cancer Prostate Sweden Study (Sweden)
Authors: Maria Hedelin
Åsa Klint
Ellen T. Chang
Rino Bellocco
Jan-Erik Johansson
Swen-Olof Andersson
Satu-Maarit Heinonen
Herman Adlercreutz
Hans-Olov Adami
Henrik Grönberg
Katarina Augustsson Bälter
Publication date: 01-03-2006
Publisher: Kluwer Academic Publishers
Published in: Cancer Causes & Control / Issue 2/2006
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-005-0342-2

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Objective

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