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01-07-2020 | Original Paper

Enhanced Regional Functional Connectivity Indicates Seizure Onset Zone

Authors: Jianpo Su, Nicolás von Ellenrieder, Dewen Hu, Jean Gotman

Published in: Brain Topography | Issue 4/2020

Abstract

This project aims to explore if stronger functional connectivity (FC) exists in the maximal BOLD response of EEG/fMRI analysis when it is concordant with seizure-onset-zone (SOZ). Twenty-six patients with drug-resistant focal epilepsy who had an EEG/fMRI and later underwent stereo-EEG implantation were included. Different types of IEDs were labeled in scalp EEG and IED-related maximal BOLD responses were evaluated separately, each constituting one study. After evaluating concordance between maximal BOLD and SOZ, twenty-seven studies were placed in the concordant group and eight in the discordant group. We evaluated the local connectivity and ipsilaterally distant connectivity difference between the maximal BOLD and the contralateral homotopic region. Significantly stronger local FC was found for the maximal BOLD in the concordant group (p < 0.05, Bonferroni corrected). 52% of the studies in the concordant group and 13% in the discordant group had a significant difference compared to healthy subjects (p < 0.05, uncorrected). The finding suggests that, when concordant with the SOZ, the maximal BOLD is more likely to have stronger local FC compared to its contralateral counterpart. This asymmetry in functional connectivity may help to noninvasively improve the specificity of EEG/fMRI analysis.

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Title: Enhanced Regional Functional Connectivity Indicates Seizure Onset Zone
Authors: Jianpo Su
Nicolás von Ellenrieder
Dewen Hu
Jean Gotman
Publication date: 01-07-2020
Publisher: Springer US
Published in: Brain Topography / Issue 4/2020
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-020-00775-4

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Enhanced Regional Functional Connectivity Indicates Seizure Onset Zone

Abstract

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