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Open Access 01-03-2020 | Epilepsy | Original Paper

Establishing a Developmentally Appropriate fMRI Paradigm Relevant to Presurgical Mapping of Memory in Children

Authors: Amanda G. Wood, Elaine Foley, Parnpreet Virk, Helen Ruddock, Paras Joshee, Kelly Murphy, Stefano Seri

Published in: Brain Topography | Issue 2/2020

Abstract

Functional magnetic resonance imaging (fMRI) is an established eloquent cortex mapping technique that is now an integral part of the pre-operative work-up in candidates for epilepsy surgery. Emerging evidence in adults with epilepsy suggests that material-specific fMRI paradigms can predict postoperative memory outcomes, however these paradigms are not suitable for children. In pediatric age, the use of memory fMRI paradigms designed for adults is complicated by the effect of developmental stages in cognitive maturation, the impairment experienced by some people with temporal lobe epilepsy (TLE) and the normal representation of memory function during development, which may differ from adults. We present a memory fMRI paradigm designed to activate mesial temporal lobe structures that is brief, independent of reading ability, and therefore a novel candidate for use in children. Data from 33 adults and 19 children (all healthy controls) show that the paradigm captures the expected leftward asymmetry of mesial temporal activation in adults. A more symmetrical pattern was observed in children, consistent with the progressive emergence of hemispheric specialisation across childhood. These data have important implications for the interpretation of presurgical memory fMRI in the pediatric setting. They also highlight the need to carefully consider the impact of cognitive development on fMRI tools used in clinical practice.

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Title: Establishing a Developmentally Appropriate fMRI Paradigm Relevant to Presurgical Mapping of Memory in Children
Authors: Amanda G. Wood
Elaine Foley
Parnpreet Virk
Helen Ruddock
Paras Joshee
Kelly Murphy
Stefano Seri
Publication date: 01-03-2020
Publisher: Springer US
Keyword: Epilepsy
Published in: Brain Topography / Issue 2/2020
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-019-00751-7

At a glance: The STEP trials

Springer Medicine

Establishing a Developmentally Appropriate fMRI Paradigm Relevant to Presurgical Mapping of Memory in Children

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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