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Brain Topography
Published in: Brain Topography 4/2018

01-07-2018 | Original Paper

Alterations in Normal Aging Revealed by Cortical Brain Network Constructed Using IBASPM

Authors: Wan Li, Chunlan Yang, Feng Shi, Qun Wang, Shuicai Wu, Wangsheng Lu, Shaowu Li, Yingnan Nie, Xin Zhang

Published in: Brain Topography | Issue 4/2018

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Abstract

Normal aging has been linked with the decline of cognitive functions, such as memory and executive skills. One of the prominent approaches to investigate the age-related alterations in the brain is by examining the cortical brain connectome. IBASPM is a toolkit to realize individual atlas-based volume measurement. Hence, this study seeks to determine what further alterations can be revealed by cortical brain networks formed by IBASPM-extracted regional gray matter volumes. We found the reduced strength of connections between the superior temporal pole and middle temporal pole in the right hemisphere, global hubs as the left fusiform gyrus and right Rolandic operculum in the young and aging groups, respectively, and significantly reduced inter-module connection of one module in the aging group. These new findings are consistent with the phenomenon of normal aging mentioned in previous studies and suggest that brain network built with the IBASPM could provide supplementary information to some extent. The individualization of morphometric features extraction deserved to be given more attention in future cortical brain network research.
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Metadata
Title
Alterations in Normal Aging Revealed by Cortical Brain Network Constructed Using IBASPM
Authors
Wan Li
Chunlan Yang
Feng Shi
Qun Wang
Shuicai Wu
Wangsheng Lu
Shaowu Li
Yingnan Nie
Xin Zhang
Publication date
01-07-2018
Publisher
Springer US
Published in
Brain Topography / Issue 4/2018
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI
https://doi.org/10.1007/s10548-018-0642-y

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