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Brain Topography
Published in: Brain Topography 3/2015

01-05-2015 | Original Paper

Masking the Auditory Evoked Potential in TMS–EEG: A Comparison of Various Methods

Authors: Esther M. ter Braack, Cecile C. de Vos, Michel J. A. M. van Putten

Published in: Brain Topography | Issue 3/2015

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Abstract

There is growing interest in combining transcranial magnetic stimulation (TMS) with electroencephalography (EEG). Because TMS pulses are accompanied by a clicking sound, it is very likely that part of the response in the EEG consists of an auditory evoked potential (AEP). Different methods have been applied to mask the sound of TMS. However, it is unclear which masking method is most effective in reducing the AEP. In this study we explore the presumed contribution of the AEP to the response and evaluate different ways to mask the TMS clicking sound. Twelve healthy subjects and one completely deaf subject participated in this study. Eight different masking conditions were evaluated in nine hearing subjects. The amplitude of the N100–P180 complex was compared between the different masking conditions. We were not able to completely suppress the N100–P180 when the coil was placed on top of the head. Using an earmuff or exposing the subjects to white or adapted noise caused a small but significant reduction in N100–P180 amplitude, but the largest reduction was achieved when combining a layer of foam, placed between coil and head, with white or adapted noise. The deaf subject also showed a N100–P180 complex. We conclude that both the TMS clicking sound and cortical activation by the magnetic pulse contribute to the N100–P180 amplitude.
Literature
Barker AT, Jalinous R, Freeston IL (1985) Non-invasive magnetic stimulation of human motor cortex. Lancet 1(8437):1106–1107CrossRefPubMed
Bikmullina R, Kičić D, Carlson S, Nikulin VV (2009) Electrophysiological correlates of short-latency afferent inhibition: a combined EEG and TMS study. Exp Brain Res 194(4):517–526CrossRefPubMed
Bonato C, Miniussi C, Rossini PM (2006) Transcranial magnetic stimulation and cortical evoked potentials: a TMS/EEG co-registration study. Clin Neurophysiol 117(8):1699–1707CrossRefPubMed
Casali AG, Casarotto S, Rosanova M, Mariotti M, Massimini M (2010) General indices to characterize the electrical response of the cerebral cortex to TMS. Neuroimage 49(2):1459–1468CrossRefPubMed
Casarotto S, Lauro LJR, Bellina V, Casali AG, Rosanova M, Pigorini A, Defendi S, Mariotti M, Massimini M (2010) EEG responses to TMS are sensitive to changes in the perturbation parameters and repeatable over time. PLoS One 5(4):e10281CrossRefPubMedCentralPubMed
Chen R, Cros D, Curra A, Lazzaro VD, Lefaucheur J-P, Magistris MR, Mills K, Rösler KM, Triggs WJ, Ugawa Y, Ziemann U (2008) The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 119(3):504–532CrossRefPubMed
Esser SK, Huber R, Massimini M, Peterson MJ, Ferrarelli F, Tononi G (2006) A direct demonstration of cortical LTP in humans: a combined TMS/EEG study. Brain Res Bull 69(1):86–94CrossRefPubMed
Ferrarelli F, Massimini M, Sarasso S, Casali A, Riedner BA, Angelini G, Tononi G, Pearce RA (2010) Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc Natl Acad Sci USA 107(6):2681–2686CrossRefPubMedCentralPubMed
Ferreri F, Pasqualetti P, Määttä S, Ponzo D, Ferrarelli F, Tononi G, Mervaala E, Miniussi C, Rossini PM (2011) Human brain connectivity during single and paired pulse transcranial magnetic stimulation. Neuroimage 54(1):90–102CrossRefPubMed
Fuggetta G, Fiaschi A, Manganotti P (2005) Modulation of cortical oscillatory activities induced by varying single-pulse transcranial magnetic stimulation intensity over the left primary motor area: a combined EEG and TMS study. Neuroimage 27(4):896–908CrossRefPubMed
Griffiths DJ (2008) Introduction to electrodynamics, 3rd edn. Pearson Benjamin Cummings, San Fransisco
Hamidi M, Slagter HA, Tononi G, Postle BR (2010) Brain responses evoked by high-frequency repetitive transcranial magnetic stimulation: an event-related potential study. Brain Stimul 3(1):2–14CrossRefPubMedCentralPubMed
Julkunen P, Jauhiainen AM, Westerén-Punnonen S, Pirinen E, Soininen H, Könönen M, Pääkkönen A, Määttä S, Karhu J (2008) Navigated TMS combined with EEG in mild cognitive impairment and Alzheimer’s disease: a pilot study. J Neurosci Methods 172(2):270–276CrossRefPubMed
Julkunen P, Säisänen L, Sarasti M, Könönen M (2009) Effect of electrode cap on measured cortical motor threshold. J Neurosci Methods 176(2):225–229CrossRefPubMed
Kähkönen S, Kesäniemi M, Nikouline VV, Karhu J, Ollikainen M, Holi M, Ilmoniemi RJ (2001) Ethanol modulates cortical activity: direct evidence with combined TMS and EEG. Neuroimage 14(2):322–328CrossRefPubMed
Kähkönen S, Komssi S, Wilenius J, Ilmoniemi RJ (2005a) Prefrontal TMS produces smaller EEG responses than motor-cortex TMS: implications for rTMS treatment in depression. Psychopharmacology 181(1):16–20CrossRefPubMed
Kähkönen S, Komssi S, Wilenius J, Ilmoniemi RJ (2005b) Prefrontal transcranial magnetic stimulation produces intensity-dependent EEG responses in humans. Neuroimage 24(4):955–960CrossRefPubMed
Kičić D, Lioumis P, Ilmoniemi RJ, Nikulin VV (2008) Bilateral changes in excitability of sensorimotor cortices during unilateral movement: combined electroencephalographic and transcranial magnetic stimulation study. Neuroscience 152(4):1119–1129CrossRefPubMed
Komssi S, Kähkönen S, Ilmoniemi RJ (2004) The effect of stimulus intensity on brain responses evoked by transcranial magnetic stimulation. Hum Brain Mapp 21(3):154–164CrossRefPubMed
Levit-Binnun N, Litvak V, Pratt H, Moses E, Zaroor M, Peled A (2010) Differences in TMS-evoked responses between schizophrenia patients and healthy controls can be observed without a dedicated EEG system. Clin Neurophysiol 121(3):332–339CrossRefPubMed
Lioumis P, Kičić D, Savolainen P, Mäkelä JP, Kähkönen S (2009) Reproducibility of TMS-evoked EEG responses. Hum Brain Mapp 30(4):1387–1396CrossRefPubMed
Mäki H, Ilmoniemi RJ (2010) The relationship between peripheral and early cortical activation induced by transcranial magnetic stimulation. Neurosci Lett 478(1):24–28CrossRefPubMed
Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G (2005) Breakdown of cortical effective connectivity during sleep. Science 309(5744):2228–2232CrossRefPubMed
Massimini M, Ferrarelli F, Murphy M, Huber R, Riedner B, Casarotto S, Tononi G (2010) Cortical reactivity and effective connectivity during REM sleep in humans. Cogn Neurosci 1(3):176–183CrossRefPubMedCentralPubMed
Miniussi C, Thut G (2009) Combining TMS and EEG offers new prospects in cognitive neuroscience. Brain Topogr 22(4):249–256
Nikouline V, Ruohonen J, Ilmoniemi RJ (1999) The role of the coil click in TMS assessed with simultaneous EEG. Clin Neurophysiol 110(8):1325–1328CrossRefPubMed
Nikulin VV, Kičić D, Kähkönen S, Ilmoniemi RJ (2003) Modulation of electroencephalographic responses to transcranial magnetic stimulation: evidence for changes in cortical excitability related to movement. Eur J Neurosci 18(5):1206–1212CrossRefPubMed
Padberg F, George MS (2009) Repetitive transcranial magnetic stimulation of the prefrontal cortex in depression. Exp Neurol 219(1):2–13CrossRefPubMed
Paus T, Sipila PK, Strafella AP (2001) Synchronization of neuronal activity in the human primary motor cortex by transcranial magnetic stimulation: an EEG study. J Neurophysiol 86(4):1983–1990PubMed
Picton TW, Hillyard SA, Krausz HI, Galambos R (1974) Human auditory evoked potentials. I. Evaluation of components. Electroencephalogr Clin Neurophysiol 36(2):179–190CrossRefPubMed
Rosanova M, Casali A, Bellina V, Resta F, Mariotti M, Massimini M (2009) Natural frequencies of human corticothalamic circuits. J Neurosci 29(24):7679–7685CrossRefPubMed
Rossi S, Hallett M, Rossini PM, Pascual-Leone A, TMS Consensus Group TS (2009) Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 120:2008–2039CrossRefPubMedCentralPubMed
Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, Dimitrijević MR, Hallett M, Katayama Y, Lücking CH (1994) Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 91(2):79–92CrossRefPubMed
Schiff S, Valenti P, Andrea P, Lot M, Bisiacchi P, Gatta A, Amodio P (2008) The effect of aging on auditory components of event-related brain potentials. Clin Neurophysiol 119(8):1795–1802CrossRefPubMed
Ter Braack E, de Jonge B, van Putten MJ (2013) Reduction of TMS Induced Artifacts in EEG Using Principal Component Analysis. IEEE Trans Neural Syst Rehabil Eng 21(3):376–382 (in press)
Tiitinen H, Virtanen J, Ilmoniemi RJ, Kamppuri J, Ollikainen M, Ruohonen J, Näätänen R (1999) Separation of contamination caused by coil clicks from responses elicited by transcranial magnetic stimulation. Clin Neurophysiol 110(5):982–985CrossRefPubMed
Veniero D, Maioli C, Miniussi C (2010) Potentiation of short-latency cortical responses by high-frequency repetitive transcranial magnetic stimulation. J Neurophysiol 104(3):1578–1588CrossRefPubMed
Werf YDVD, Paus T (2006) The neural response to transcranial magnetic stimulation of the human motor cortex. I. Intracortical and cortico-cortical contributions. Exp Brain Res 175(2):231–245CrossRef
Metadata
Title
Masking the Auditory Evoked Potential in TMS–EEG: A Comparison of Various Methods
Authors
Esther M. ter Braack
Cecile C. de Vos
Michel J. A. M. van Putten
Publication date
01-05-2015
Publisher
Springer US
Published in
Brain Topography / Issue 3/2015
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI
https://doi.org/10.1007/s10548-013-0312-z

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