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01-04-2012 | Original Paper

Source Connectivity Analysis from MEG and its Application to Epilepsy Source Localization

Authors: Yakang Dai, Wenbo Zhang, Deanna L. Dickens, Bin He

Published in: Brain Topography | Issue 2/2012

Abstract

We report an approach to perform source connectivity analysis from MEG, and initially evaluate this approach to interictal MEG to localize epileptogenic foci and analyze interictal discharge propagations in patients with medically intractable epilepsy. Cortical activities were reconstructed from MEG using individual realistic geometry boundary element method head models. Directional connectivity among cortical regions of interest was then estimated using directed transfer function. The MEG source connectivity analysis method was implemented in the eConnectome software, which is open-source and freely available at http://econnectome.umn.edu. As an initial evaluation, the method was applied to study MEG interictal spikes from five epilepsy patients. Estimated primary epileptiform sources were consistent with surgically resected regions, suggesting the feasibility of using cortical source connectivity analysis from interictal MEG for potential localization of epileptiform activities.

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Title: Source Connectivity Analysis from MEG and its Application to Epilepsy Source Localization
Authors: Yakang Dai
Wenbo Zhang
Deanna L. Dickens
Bin He
Publication date: 01-04-2012
Publisher: Springer US
Published in: Brain Topography / Issue 2/2012
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-011-0211-0

At a glance: The STEP trials

Springer Medicine

Source Connectivity Analysis from MEG and its Application to Epilepsy Source Localization

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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