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01-06-2017 | Original Investigation

Impact of depression and anxiety disorders on adherence to oral hypoglycemics in older adults with diabetes mellitus in Canada

Authors: Lia Gentil, Helen-Maria Vasiliadis, Djamal Berbiche, Michel Préville

Published in: European Journal of Ageing | Issue 2/2017

Abstract

The prevalence of diabetes mellitus is increasing in Canada, and nonadherence to oral hypoglycemics is a common problem among older adults. This study aims to document the impact of depression and anxiety disorders on adherence to oral hypoglycemics in older adults with diabetes mellitus. Data used in this study came from the longitudinal Quebec survey on senior’s health (Enquête sur la Santé des Ainés), using a representative sample of 2811 older adults aged 65 and over. The final sample for analysis consisted of 301 patients who received oral hypoglycemic pharmacotherapy. Medication adherence was measured with the medication possession ratio. An adapted version of Andersen’s behavioral model was used to explain adherence to oral hypoglycemic medication while considering the following predisposing factors: age, gender, and level of education: enabling factors: marital status and income level: and need factors: physical and mental health status. Our explanatory model of oral hypoglycemic medication adherence was tested using a latent growth curve model. The results of the multiple-group analysis did not show any significant difference in oral hypoglycemic medication adherence (p > 0.05). Furthermore, individuals with higher levels of education were less adherent to oral hypoglycemics than those with lower levels of education (p < 0.05). Medication adherence to oral hypoglycemics did not show any significant difference between participants with and without depression and anxiety disorders. Future studies with larger samples are needed to fully explore the association between mental disorders and oral hypoglycemic medication adherence in the older adult populations.

Andersen R, Newman JF (1973) Societal and individual determinants of medical care utilization in the United States. Milbank Meml Fund Q Health Soc 51(1):95–124CrossRef

Anderson RJ, Grigsby AB, Freedland KE, de Groot M, McGill JB, Clouse RE et al (2002) Anxiety and poor glycemic control: a meta-analytic review of the literature. Int J Psychiatry Med 32(3):235–247CrossRef

Balkrishnan R (1998) Predictors of medication adherence in the elderly. Clin Ther 20(4):764–771CrossRef

Balkrishnan R, Rajagopalan R, Camacho FT, Huston SA, Murray FT, Anderson RT (2003) Predictors of medication adherence and associated health care costs in an older population with type 2 diabetes mellitus: a longitudinal cohort study. Clin Ther 25:2958–2971CrossRef

Bandura A (1977) Self-efficacy: toward a unifying theory of behavior change. Psychol Rev 84:191–215CrossRef

Becker MH (1974) The health belief model and personal health behavior. Health Educ Monogr 2:324–473CrossRef

Bouwman V, Adriaanse MC, van ‘t Riet E, Snoek FJ, Dekker JM, Nijpels G (2010) Depression, anxiety and glucose metabolism in the general Dutch population: the new Hoorn study. PLoS One 5(4):e9971CrossRef

Bucholz KK, Marion SL, Shayka JJ, Marcus SC, Robins LN (1996) A short computer interview for obtaining psychiatric diagnoses. Psychiatr Serv 47(3):293–297CrossRef

Burke WJ, Houston MJ, Boust SJ, Roccaforte WH (1989) Use of the geriatric depression scale in dementia of the Alzheimer type. J Am Geriatr Soc 37(9):856–860CrossRef

Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383CrossRef

Choo PW, Rand CS, Inuit TS, Lee ML, Cain E, Cordeiro-Breault M et al (1999) Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care 37(9):846–857CrossRef

Ciechanowski PS, Katon WJ, Russo JE (2000) Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med 160(21):3278–3285CrossRef

Collins MM, Corcoran P, Perry IJ (2009) Anxiety and depression symptoms in patients with diabetes. Diabet Med 26(2):153–161CrossRef

Cramer JA (2004) A systematic review of adherence with medications for diabetes. Diabetes Care 27(5):1218–1224CrossRef

Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA et al (2008) Medication compliance and persistence: terminology and definitions. Value Health 11(1):44–47CrossRef

Crum RM, Anthony JC, Bassett SS, Folstein MF (1993) Population-based norms for the mini-mental state examination by age and educational level. JAMA 269(18):2386–2391CrossRef

Cummings KM, Becker MH, Maile MC (1980) Bringing the models together: an empirical approach to combining the variables used to explain health actions. J Behav Med 3:123–145CrossRef

Dailey G, Kim MS, Lian JF (2001) Patient compliance and persistence with antihyperglycemic drug regimens: evaluation of a medicaid patient population with type 2 diabetes mellitus. Clin Ther 23(8):1311–1320CrossRef

Das-Munshi J, Stewart R, Ismail K, Bebbington PE, Jenkins R, Prince MJ (2007) Diabetes, common mental disorders, and disability: findings from the UK national psychiatric morbidity survey. Psychosom Med 69(6):543–550CrossRef

De Smet BD, Erickson SR, Kirking DM (2006) Self-reported adherence in patients with asthma. Ann Pharmacother 40(3):414–420CrossRef

DiMatteo MR (2004) Variations in patients’ adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 42(3):200–209CrossRef

Duncan TE, Duncan SC, Strycker LA, Li F, Alpert A (1999) An introduction to latent variable growth curve modeling: Concepts, Issues, and Applications. Lawrence Erlbaum Associates Publishers, Mahwah

Engum A (2007) The role of depression and anxiety in onset of diabetes in a large population-based study. J Psychosom Res 62(1):31–38CrossRef

Erdman HP, Klein MH, Greist JH, Skare SS, Husted JJ, Robins LN et al (1992) A comparison of two computer-administered versions of the NIMH diagnostic interview schedule. J Psychosom Res 26(1):85–95CrossRef

Floyd DL, Prentice-Dunn S, Rogers RW (2000) A meta-analysis of research on protection motivation theory. J Community Appl Soc Psychol 30:407–429CrossRef

Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychosom Res 12(3):189–198CrossRef

Gonzalez JS, Peyrot M, McCarl LA, Collins EM, Serpa L, Mimiaga MJ et al (2008) Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care 31(12):2398–2403CrossRef

Horn OK, Jacobs-Whyte H, Ing A, Bruegl A, Paradis G, Macaulay AC (2007) Incidence and prevalence of type 2 diabetes in the first nation community of kahnawà: Ke, Quebec, Canada, 1986–2003. Can J Public Health 98(6):438–443

Hughes CM (2004) Medication non-adherence in the elderly: How big is the problem? Drugs Aging 21(12):793–811CrossRef

Jin J, Sklar GE, Min Sen Oh V, Chuen Li S (2008) Factors affecting therapeutic compliance: a review from the patient’s perspective. Ther Clin Risk Manag 4(1):269–286

Jöreskog K, Sörbom D (1993) LISREL VIII: user’s reference guide. Scientific Software, Mooresville

Kafonek S, Ettinger WH, Roca R, Kittner S, Taylor N, German PS (1989) Instruments for screening for depression and dementia in a long-term care facility. J Am Geriatr Soc 37(1):29–34CrossRef

Kendzor DE, Chen M, Reininger BM, Businelle MS, Stewart DW, Fisher-Hoch SP, Rentfro AR, Wetter DW, McCormick JB (2014) The association of depression and anxiety with glycemic control among Mexican Americans with diabetes living near the U.S.–Mexico border. BMC Public Health 14:176CrossRef

Khattab M, Khader YS, Al-Khawaldeh A, Ajlouni K (2010) Factors associated with poor glycemic control among patients with type 2 diabetes. J Diabetes Complicat 24(2):84–89CrossRef

Kilbourne AM, Reynolds CF, Good CB, Sereika SM, Justice AC, Fine MJ (2005) How does depression influence diabetes medication adherence in older patients? J Am Geriatr Soc 13(3):202–210CrossRef

Koro CE, Bowlin SJ, Bourgeois N, Fedder DO (2004) Glycemic control from 1988 to 2000 among U.S. adults diagnosed with type 2 diabetes: a preliminary report. Diabetes Care 27(1):17–20CrossRef

Krass I, Schieback P, Dhippayom T (2015) Adherence to diabetes medication: a systematic review. Diabet Med 32(6):725–737CrossRef

Leventhal H, Cameron L (1987) Behavioral theories and the problem of compliance. Patient Educ Couns 10(2):117–138CrossRef

Lin EH, Katon W, Von Korff M, Rutter C, Simon GE, Oliver M et al (2004) Relationship of depression and diabetes self-care, medication adherence, and preventive care. Diabetes Care 27(9):2154–2160CrossRef

Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE (2000) Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 23(7):934–942CrossRef

Lynch T (2006) Medication costs as a primary cause of nonadherence in the elderly. Consult Pharm 21(2):143–146CrossRef

Mann DM, Ponieman D, Leventhal H, Halm EA (2009) Predictors of adherence to diabetes medications: the role of disease and medication beliefs. J Behav Med 32:278–284CrossRef

Melikian C, White TJ, Vanderplas A, Dezii CM, Chang E (2002) Adherence to oral antidiabetic therapy in a managed care organization: a comparison of monotherapy, combination therapy, and fixed-dose combination therapy. Clin Ther 24(3):460–467CrossRef

Morningstar BA, Sketris IS, Kephart GC, Sclar DA (2002) Variation in pharmacy prescription refill adherence measures by type of oral antihyperglycaemic drug therapy in seniors in Nova Scotia, Canada. J Clin Pharm Ther 27(3):213–220CrossRef

Murray MD, Morrow DG, Weiner M, Clark DO, Tu W, Deer MM et al (2004) A conceptual framework to study medication adherence in older adults. Am J Geriatr Pharmacother 2(1):36–43CrossRef

Nau DP, Aikens JE, Pacholski AM (2007) Effects of gender and depression on oral medication adherence in persons with type 2 diabetes mellitus. Gend Med 4(3):205–213CrossRef

Park DC, Morrell RW, Frieske D, Kincaid D (1992) Medication adherence behaviors in older adults: effects of external cognitive supports. Psychol Aging 7:252–256CrossRef

Preville M, Boyer R, Grenier S, Dube M, Voyer P, Punti R et al (2008) The epidemiology of psychiatric disorders in Quebec’s older adult population. Can J Psychiatry 53(12):822–832CrossRef

Prochaska JO, DiClemente CC (1982) Transtheoretical therapy toward a more integrative model of change. Psychother Theory Res Pract 19(3):276–287CrossRef

Public Health Agency of Canada. Report from the national diabetes surveillance system: diabetes in Canada, 2009. Ottawa. http://www.phac-aspc.gc.ca/publicat/2009/ndssdic-snsddac-09/index-eng.php. Accessed 15 Dec 2015

Romero-Aroca P, Mendez-Marin I, Baget-Bernaldiz M, Fernendez-Ballart J, Santos-Blanco E (2010) Review of the relationship between renal and retinal microangiopathy in diabetes mellitus patients. Curr Diabetes Rev 6(2):88–101CrossRef

Rosenstock IM (1974) The health belief model and preventive health behavior. Health Educ Monogr 2:354–368CrossRef

Rubin RR (2005) Adherence to pharmacologic therapy in patients with type 2 diabetes mellitus. Am J Med 118(Suppl 5A):27S–34SCrossRef

Salas M, In’t Veld BA, van der Linden PD, Hofman A, Breteler M, Stricker BH (2001) Impaired cognitive function and compliance with antihypertensive drugs in elderly: the Rotterdam Study. Clin Pharmacol Ther 70:561–566CrossRef

Senior V, Marteau TM, Weinman J, Genetic Risk Assessment for FH Trial (GRAFT) Study Group (2004) Self-reported adherence to cholesterol-lowering medication in patients with familial hypercholesterolaemia: the role of illness perceptions. Cardiovasc Drugs Ther 18(6):475–481CrossRef

Steiner JF, Prochazka AV (1997) The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol 50(1):105–116CrossRef

Tamblyn R, Lavoie G, Petrella L, Monette J (1995) The use of prescription claims databases in pharmacoepidemiological research: the accuracy and comprehensiveness of the prescription claims database in Quebec. J Clin Epidemiol 48(8):999–1009CrossRef

Van Buuren S, van Rijckevorsel JLA (1992) Imputation of missing categorical data by maximizing internal consistency. Psychometrika 57(4):567–580CrossRef

Vik SA, Maxwell CJ, Hogan DB (2004) Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother 38(2):303–312CrossRef

Wittchen HU, Robins LN, Cottler LB, Sartorius N, Burke JD, Regier D (1991) Cross-cultural feasibility, reliability and sources of variance of the composite international diagnostic interview (CIDI). The multicentre WHO/ADAMHA field trials. Br J Psychiatry 159(645–53):658

Title: Impact of depression and anxiety disorders on adherence to oral hypoglycemics in older adults with diabetes mellitus in Canada
Authors: Lia Gentil
Helen-Maria Vasiliadis
Djamal Berbiche
Michel Préville
Publication date: 01-06-2017
Publisher: Springer Netherlands
Published in: European Journal of Ageing / Issue 2/2017
Print ISSN: 1613-9372
Electronic ISSN: 1613-9380
DOI: https://doi.org/10.1007/s10433-016-0390-3

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Impact of depression and anxiety disorders on adherence to oral hypoglycemics in older adults with diabetes mellitus in Canada

Abstract

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