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Published in: Gynecological Surgery 3/2016

01-08-2016 | Original Article

The impact of uterine artery embolization to reduce postpartum hysterectomy

Authors: Mee Kristine Aas-Eng, Erik Qvigstad, Nils-Einar Kløw, Kirsten Hald

Published in: Gynecological Surgery | Issue 3/2016

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Abstract

Uterine artery embolization (UAE) has been part of treatment options for postpartum hemorrhage (PPH) at Oslo University Hospital since 2007. We wanted to investigate if introduction of UAE influenced the incidence of postpartum hysterectomy and in addition to evaluate clinical success and fertility after UAE. This retrospective study includes patients treated for severe PPH undergoing UAE from 2007 to 2010 and patients undergoing hysterectomy in the period before (2003–2006) and after (2007–2010) the introduction of UAE. Hospital records were reviewed. Patients who were embolized were contacted with a questionnaire to evaluate fertility. We observed a decrease in the incidence of postpartum hysterectomy since introduction of UAE for PPH; however, the reduction was not significant (0.40/1000 versus 0.35/1000, p = 0.80). UAE resulted in clinical success in 28 patients (82 %). None were re-embolized. Twenty women were hysterectomized. Five of these patients had preceding embolization, four were hysterectomized due to re-bleeding, and one due to sepsis with suspected uterine necrosis. One patient had a uterine horn removed due to bleeding. Nine women became pregnant after UAE. There were 11 reported pregnancies and 8 live births. PPH re-occurred in 63 % of live births, with median bleeding volume of 700 ml (range 500–1600 ml). Introducing UAE decreased postpartum hysterectomy rate in our department, however not significant. Our success rate of UAE (82 %) is in line with previously published data. UAE may preserve fertility potential. High recurrence rate of PPH after previous UAE was observed.
Literature
1.
go back to reference Oyelese Y, Ananth CV (2010) Postpartum hemorrhage: epidemiology, risk factors and causes. Clin Obstet Gynecol 53:147–156CrossRefPubMed Oyelese Y, Ananth CV (2010) Postpartum hemorrhage: epidemiology, risk factors and causes. Clin Obstet Gynecol 53:147–156CrossRefPubMed
2.
go back to reference Al-Ziqiri I, Vangen S, Forsen L, Stray-Pedersen B (2008) Prevalence and risk factors of severe obstetric haemorrhage. Br J Obstet Gynaecol 115:1265–1272CrossRef Al-Ziqiri I, Vangen S, Forsen L, Stray-Pedersen B (2008) Prevalence and risk factors of severe obstetric haemorrhage. Br J Obstet Gynaecol 115:1265–1272CrossRef
3.
go back to reference ACOG Practice Bulletin (2006) Clinical management guidelines for obstetrician-gynecologists number 76: postpartum hemorrhage. Obstet Gynecol 108:1039–1047CrossRef ACOG Practice Bulletin (2006) Clinical management guidelines for obstetrician-gynecologists number 76: postpartum hemorrhage. Obstet Gynecol 108:1039–1047CrossRef
4.
go back to reference Pelage JP, Le Dref O, Mateo J et al (1998) Life-threatening primary postpartum hemorrhage: treatment with emergency selective arterial embolization. Radiology 208:359–362CrossRefPubMed Pelage JP, Le Dref O, Mateo J et al (1998) Life-threatening primary postpartum hemorrhage: treatment with emergency selective arterial embolization. Radiology 208:359–362CrossRefPubMed
5.
go back to reference Deux JF, Bazot M, Le Blanche AF et al (2001) Is selective embolization of uterine arteries a safe alternative to hysterectomy in patients with postpartum hemorrhage? Am J Roentgenol 177:145–149CrossRef Deux JF, Bazot M, Le Blanche AF et al (2001) Is selective embolization of uterine arteries a safe alternative to hysterectomy in patients with postpartum hemorrhage? Am J Roentgenol 177:145–149CrossRef
6.
go back to reference Brown BJ, Heaston DK, Poulson AM, Gabert HA, Mineau DE, Miller FJ (1979) Uncontrollable postpartum bleeding: a new approach to hemostasis through angiographic arterial embolization. Obstet Gynecol 54:361–365PubMed Brown BJ, Heaston DK, Poulson AM, Gabert HA, Mineau DE, Miller FJ (1979) Uncontrollable postpartum bleeding: a new approach to hemostasis through angiographic arterial embolization. Obstet Gynecol 54:361–365PubMed
7.
go back to reference Ganguli S, Stecker MS, Pyne D, Baum RA, Fan CM (2011) Uterine artery embolization in the treatment of postpartum uterine hemorrhage. J Vasc Interv Radiol 22:169–176CrossRefPubMed Ganguli S, Stecker MS, Pyne D, Baum RA, Fan CM (2011) Uterine artery embolization in the treatment of postpartum uterine hemorrhage. J Vasc Interv Radiol 22:169–176CrossRefPubMed
8.
go back to reference Salomon LJ, de Tayrac R, Castaigne-Meary V et al (2003) Fertility and pregnancy outcome following pelvic arterial embolization for severe post-partum haemorrhage. A cohort study. Hum Reprod 18:849–852CrossRefPubMed Salomon LJ, de Tayrac R, Castaigne-Meary V et al (2003) Fertility and pregnancy outcome following pelvic arterial embolization for severe post-partum haemorrhage. A cohort study. Hum Reprod 18:849–852CrossRefPubMed
9.
go back to reference Chaleur C, Fanget C, Tourne G, Levy R, Larchez C, Seffert P (2008) Serious primary post-partum hemorrhage, arterial embolization and future fertility: a retrospective study of 46 cases. Hum Reprod 23:1553–1560CrossRef Chaleur C, Fanget C, Tourne G, Levy R, Larchez C, Seffert P (2008) Serious primary post-partum hemorrhage, arterial embolization and future fertility: a retrospective study of 46 cases. Hum Reprod 23:1553–1560CrossRef
10.
go back to reference Descargues G, Mauger Tinlot F, Douvrin F, Clavier E, Lemoine JP, Marpeau L (2004) Menses, fertility and pregnancy after arterial embolization for the control of postpartum hemorrhage. Hum Reprod 19:339–343CrossRefPubMed Descargues G, Mauger Tinlot F, Douvrin F, Clavier E, Lemoine JP, Marpeau L (2004) Menses, fertility and pregnancy after arterial embolization for the control of postpartum hemorrhage. Hum Reprod 19:339–343CrossRefPubMed
11.
go back to reference Ornan DW, White R, Pollak J, Tal M (2003) Pelvic embolization for intractable postpartum hemorrhage: long-term follow-up and implications for fertility. Obstet Gynecol 102:904–910PubMed Ornan DW, White R, Pollak J, Tal M (2003) Pelvic embolization for intractable postpartum hemorrhage: long-term follow-up and implications for fertility. Obstet Gynecol 102:904–910PubMed
12.
go back to reference Grönvall M, Tikkanen M, Metsätähti M, Loukovaara M, Paavonen J, Stefanovic V (2014) Pelvic arterial embolization in severe obstetric hemorrhage. Acta Obstet Gynecol Scand 19:716–719CrossRef Grönvall M, Tikkanen M, Metsätähti M, Loukovaara M, Paavonen J, Stefanovic V (2014) Pelvic arterial embolization in severe obstetric hemorrhage. Acta Obstet Gynecol Scand 19:716–719CrossRef
13.
go back to reference Cheong JY, Kong TK, Son JH, Won JH, Yang JI, Kim HS (2014) Outcome of pelvic arterial embolization for postpartum hemorrhage: a retrospective review of 117 cases. Obstet Gynecol Sci 57:17–27CrossRefPubMedPubMedCentral Cheong JY, Kong TK, Son JH, Won JH, Yang JI, Kim HS (2014) Outcome of pelvic arterial embolization for postpartum hemorrhage: a retrospective review of 117 cases. Obstet Gynecol Sci 57:17–27CrossRefPubMedPubMedCentral
14.
go back to reference Zwart JJ, Dijk PD, van Roosmalen J (2010) Peripartum hysterectomy and arterial embolization for major obstetric hemorrhage: a 2-year nationwide cohort study in the Netherlands. Am J Obstet Gynecol 202:150–157CrossRefPubMed Zwart JJ, Dijk PD, van Roosmalen J (2010) Peripartum hysterectomy and arterial embolization for major obstetric hemorrhage: a 2-year nationwide cohort study in the Netherlands. Am J Obstet Gynecol 202:150–157CrossRefPubMed
15.
go back to reference Kirby JM, Kachura JR, Rajan DK et al (2009) Arterial embolization for primary postpartum hemorrhage. J Vasc Interv Radiol 20:1036–1045CrossRefPubMed Kirby JM, Kachura JR, Rajan DK et al (2009) Arterial embolization for primary postpartum hemorrhage. J Vasc Interv Radiol 20:1036–1045CrossRefPubMed
16.
go back to reference Ødegaard E, Qvigstad E, Kløw E (2003) Alvorlig post partum-blødning behandlet med selektiv arteriell embolisering. [Intractable postpartum haemorrhage treated with selective arterial embolisation.] (in Norwegian. English summary available). Tidsskr Nor Lægeforen 13:2715–2716 Ødegaard E, Qvigstad E, Kløw E (2003) Alvorlig post partum-blødning behandlet med selektiv arteriell embolisering. [Intractable postpartum haemorrhage treated with selective arterial embolisation.] (in Norwegian. English summary available). Tidsskr Nor Lægeforen 13:2715–2716
17.
go back to reference Rajan PV (2010) Postpartum hemorrhage: evidence-based medical interventions for prevention and treatment. Clin Obstet Gynecol 53:165–181CrossRefPubMed Rajan PV (2010) Postpartum hemorrhage: evidence-based medical interventions for prevention and treatment. Clin Obstet Gynecol 53:165–181CrossRefPubMed
18.
go back to reference Søvik E, Stokkeland P, Storm BS, Åsheim P, Bolås O (2012) The use of aortic balloon catheter without fluoroscopy for life-threatening postpartum hemorrhage. Acta Anesthesiol Scand 56:388–393CrossRef Søvik E, Stokkeland P, Storm BS, Åsheim P, Bolås O (2012) The use of aortic balloon catheter without fluoroscopy for life-threatening postpartum hemorrhage. Acta Anesthesiol Scand 56:388–393CrossRef
20.
go back to reference Kramer MS, Berg C, Abenhaim H et al (2013) Incidence, risk factors, and temporal trends in severe postpartum hemorrhage. Am J Obstet Gynecol 209:449–456CrossRefPubMed Kramer MS, Berg C, Abenhaim H et al (2013) Incidence, risk factors, and temporal trends in severe postpartum hemorrhage. Am J Obstet Gynecol 209:449–456CrossRefPubMed
21.
go back to reference Joseph KS, Rouleau J, Kramer MS, Young DC, Liston RM, Baskett TF (2007) The Maternal Health Study Group of the Canadian perinatal surveillance system. Investigation of an increase in postpartum hemorrhage in Canada. Br J Obstet Gynaecol 114:751–759CrossRef Joseph KS, Rouleau J, Kramer MS, Young DC, Liston RM, Baskett TF (2007) The Maternal Health Study Group of the Canadian perinatal surveillance system. Investigation of an increase in postpartum hemorrhage in Canada. Br J Obstet Gynaecol 114:751–759CrossRef
22.
go back to reference Imudia AN, Awonguga AO, Dbouk T et al (2009) Incidence, trends, risk factors, indications for, and complications associated with caesarean hysterectomy: a 17-year experience from a single institution. Arch Gynecol Obstet 280:619–623CrossRefPubMed Imudia AN, Awonguga AO, Dbouk T et al (2009) Incidence, trends, risk factors, indications for, and complications associated with caesarean hysterectomy: a 17-year experience from a single institution. Arch Gynecol Obstet 280:619–623CrossRefPubMed
23.
go back to reference Smith J, Mousa HA (2007) Peripartum hysterectomy for primary postpartum haemorrhage: incidence and maternal morbidity. J Obstet Gyaecol 27:44–47CrossRef Smith J, Mousa HA (2007) Peripartum hysterectomy for primary postpartum haemorrhage: incidence and maternal morbidity. J Obstet Gyaecol 27:44–47CrossRef
24.
go back to reference Sentilhes L, Gromez A, Clavier E, Resch B, Verspyck E, Marpeau L (2009) Predictors of failed pelvic arterial embolization for severe postpartum hemorrhage. Obstet Gynecol 113:992–999CrossRefPubMed Sentilhes L, Gromez A, Clavier E, Resch B, Verspyck E, Marpeau L (2009) Predictors of failed pelvic arterial embolization for severe postpartum hemorrhage. Obstet Gynecol 113:992–999CrossRefPubMed
25.
go back to reference Poujade O, Zappa M, Letendre I, Ceccaldi PF, Vilgrain V, Luton D (2012) Predictive factors for failure of pelvic arterial embolization for postpartum hemorrhage. Int J Gynecol Obstet 117:119–123CrossRef Poujade O, Zappa M, Letendre I, Ceccaldi PF, Vilgrain V, Luton D (2012) Predictive factors for failure of pelvic arterial embolization for postpartum hemorrhage. Int J Gynecol Obstet 117:119–123CrossRef
26.
go back to reference Hardeman S, Decroisette E, Marin B et al (2010) Fertility after embolization of the uterine arteries to treat obstetrical hemorrhage: a review of 53 cases. Fertil Steril 94:2574–2579CrossRefPubMed Hardeman S, Decroisette E, Marin B et al (2010) Fertility after embolization of the uterine arteries to treat obstetrical hemorrhage: a review of 53 cases. Fertil Steril 94:2574–2579CrossRefPubMed
27.
go back to reference Fiori O, Deux JF, Kamale JC, Uzan S, Bougdhene F, Berkane N (2009) Impact of pelvic arterial embolization for intractable postpartum hemorrhage on fertility. Am J Obstet Gynecol 200:384–388CrossRefPubMed Fiori O, Deux JF, Kamale JC, Uzan S, Bougdhene F, Berkane N (2009) Impact of pelvic arterial embolization for intractable postpartum hemorrhage on fertility. Am J Obstet Gynecol 200:384–388CrossRefPubMed
28.
go back to reference Eriksson LG, Mulic-Lutica A, Jangland L, Nyman R (2007) Massive postpartum hemorrhage treated with transcatheter arterial embolization: technical aspects and long-term effects of fertility and menstrual cycle. Acta Radiol 6:635–642CrossRef Eriksson LG, Mulic-Lutica A, Jangland L, Nyman R (2007) Massive postpartum hemorrhage treated with transcatheter arterial embolization: technical aspects and long-term effects of fertility and menstrual cycle. Acta Radiol 6:635–642CrossRef
29.
go back to reference Shim JY, Yoon HK, Won HS, Kims SK, Lee PR, Kim A (2006) Angiographic embolization for obstetrical hemorrhage: effectiveness and follow-up outcome of fertility. Acta Obstet Gynecol Scand 96:815–820CrossRef Shim JY, Yoon HK, Won HS, Kims SK, Lee PR, Kim A (2006) Angiographic embolization for obstetrical hemorrhage: effectiveness and follow-up outcome of fertility. Acta Obstet Gynecol Scand 96:815–820CrossRef
Metadata
Title
The impact of uterine artery embolization to reduce postpartum hysterectomy
Authors
Mee Kristine Aas-Eng
Erik Qvigstad
Nils-Einar Kløw
Kirsten Hald
Publication date
01-08-2016
Publisher
Springer Berlin Heidelberg
Published in
Gynecological Surgery / Issue 3/2016
Print ISSN: 1613-2076
Electronic ISSN: 1613-2084
DOI
https://doi.org/10.1007/s10397-016-0936-6

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