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Journal of Public Health
Published in: Journal of Public Health 6/2017

01-12-2017 | Original Article

Systematic review and meta-analysis: dairy consumption and hepatocellular carcinoma risk

Authors: Yunyun Yang, Ju Zhou, Ying Yang, Zhi Chen, Xiaodong Zheng

Published in: Journal of Public Health | Issue 6/2017

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Abstract

Aim

This study conducts a systematic review and meta-analysis to assess the association between dairy consumption and hepatocellular carcinoma (HCC) risk.

Subjects and methods

The association between consumption of overall dairy, specific dairy products (such as milk, cheese, butter, yoghurt, condensed milk, whey, casein, lactose) and HCC risk has not been assessed before. This association between dairy consumption and HCC risk has been reported in several epidemiological studies, but results were controversial and inconsistent. The PubMed, EMBASE and Cochrane databases were searched for relevant studies published up to September 20, 2015. The relative risks (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs) for dairy consumption associated with HCC risk were extracted from each included cohort as well as case-control study. In our study, the pooled RR was obtained using the random-effects model. Heterogeneity was evaluated by Q and I 2 statistics.

Results

A total number of 1,084,666 participants and 2041 HCC patients from three cohort studies and five case-control studies were included in this meta-analysis. The pooled RR of dairy was 1.38 (95% CI: 1.00–1.91, p = 0.00) in all studies. The pooled RR of milk, yoghurt, and cheese was 1.13 (95% CI: 0.67–1.88, p = 0.00), 0.40 (95% CI: 0.14–1.14, p = 0.00) and 1.45 (95% CI: 1.02–2.07, p = 0.80), respectively.

Conclusions

This meta-analysis indicates that consumption of overall dairy may be associated with increased HCC risk and a risk factor involved in the etiology of HCC.
Appendix
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Metadata
Title
Systematic review and meta-analysis: dairy consumption and hepatocellular carcinoma risk
Authors
Yunyun Yang
Ju Zhou
Ying Yang
Zhi Chen
Xiaodong Zheng
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Journal of Public Health / Issue 6/2017
Print ISSN: 2198-1833
Electronic ISSN: 1613-2238
DOI
https://doi.org/10.1007/s10389-017-0806-3

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