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Japanese Journal of Ophthalmology
Published in: Japanese Journal of Ophthalmology 6/2018

01-11-2018 | Clinical Investigation

Topical non-steroidal anti-inflammatory drugs for the treatment of cystoid macular edema post Descemet’s stripping automated endothelial keratoplasty

Authors: Koji Kitazawa, Kanae Kayukawa, Koichi Wakimasu, Tsutomu Inatomi, Osamu Hieda, Kazuhiko Mori, Chie Sotozono, Shigeru Kinoshita

Published in: Japanese Journal of Ophthalmology | Issue 6/2018

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Abstract

Purpose

To investigate the effectiveness of topical non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of cystoid macular edema (CME) post Descemet’s stripping automated endothelial keratoplasty (DSAEK).

Study design

Retrospective observational study

Methods

In this study of 334 patients who underwent DSAEK at the Baptist Eye Institute, Kyoto, Japan between July 2011 and December 2015, 18 patients with postoperative CME (determined by optical coherence tomography) treated with topical NSAIDs after the onset of CME were included.

Results

At CME onset, 17 of the 18 patients were treated with bromfenac eye drops and 1 was treated with nepafenac eye drops. Post initiation of treatment with topical NSAIDs, CME in 17 (94.4%) of the 18 patients improved at 1 month and all cases completely recovered within 3 months. At 12-months post initiation of treatment, 61.1% (n = 11) of patients achieved a visual acuity (VA) of 20/40 or better, and there was no significant difference of VA between the patients with or without an episode of postoperative CME (P = 0.55).

Conclusion

The administration of topical NSAID eye drops was found to be effective in treating patients with CME post DSAEK.
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Metadata
Title
Topical non-steroidal anti-inflammatory drugs for the treatment of cystoid macular edema post Descemet’s stripping automated endothelial keratoplasty
Authors
Koji Kitazawa
Kanae Kayukawa
Koichi Wakimasu
Tsutomu Inatomi
Osamu Hieda
Kazuhiko Mori
Chie Sotozono
Shigeru Kinoshita
Publication date
01-11-2018
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 6/2018
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-018-0621-6

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