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European Surgery

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01-06-2015 | Original Article

Surgical intervention does not affect short-term plasma citrulline levels in infants: implications for citrulline as a marker of postoperative intestinal complications

Authors: Dr. med. G. Frongia, S. Weih, P. Romero, A. Mehrabi, S. Holland-Cunz, P. Günther

Published in: European Surgery | Issue 3/2015

Summary

Background and aims

Detection of intestinal ischemia is often delayed causing extensive complications. Serum citrulline is an important parameter for bowel integrity and functionality; however, no data is available on its response on postoperative intestinal impairment in children. The aim of this study was to evaluate the native effects of intestinal surgery on the postoperative citrulline course in children.

Material and methods

In two groups, of each five children under the age of 2, undergoing either intestinal surgery (IS) or non-intestinal surgery (NIS), we monitored unspecific intestinal impairment parameters (lactate, C-reactive protein (CRP), leukocytes) and citrulline prior to surgery and on the 3rd postoperative day.

Results

In both groups the postoperative course was uneventful, including unproblematic transition to a normal diet and regular stool. Postoperatively, CRP levels were slightly increased (IS p > 0.05; NIS p < 0.05) while leukocytes and lactate levels did not show any significant changes. The citrulline levels remained constant in the perioperative period.

Conclusions

This data suggests that IS does not affect perioperative citrulline levels in children under the age of 2 years with uneventful postoperative course. Changes in citrulline following surgery might be a sign of intestinal impairment and therefore further investigations are necessary on this field.

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Title: Surgical intervention does not affect short-term plasma citrulline levels in infants: implications for citrulline as a marker of postoperative intestinal complications
Authors: Dr. med. G. Frongia
S. Weih
P. Romero
A. Mehrabi
S. Holland-Cunz
P. Günther
Publication date: 01-06-2015
Publisher: Springer Vienna
Published in: European Surgery / Issue 3/2015
Print ISSN: 1682-8631
Electronic ISSN: 1682-4016
DOI: https://doi.org/10.1007/s10353-015-0312-1

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Surgical intervention does not affect short-term plasma citrulline levels in infants: implications for citrulline as a marker of postoperative intestinal complications

Summary

Background and aims

Material and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

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Summary

Background and aims

Material and methods

Results

Conclusions

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