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Published in: European Surgery 3/2015

01-06-2015 | Original Article

Antecolic anastomosis and delayed gastric emptying: still a benefit in patients without intra-abdominal complications?

Authors: M. Beisani, MD, C. Dopazo, MD, PhD, L. Blanco, MD, M. Caralt, MD, G. Sapisochín, MD, PhD, J-J Olsina, MD, PhD, J. Balsells, MD, PhD

Published in: European Surgery | Issue 3/2015

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Summary

Background/Aims

The etiology of delayed gastric emptying (DGE) after pylorus-preserving pancreatoduodenectomy (PPPD) is unclear. This study aimed to ascertain the incidence of DGE in a transmesocolic anastomosis (TA) versus an antecolic anastomosis (AA) group of patients.

Methods

Retrospective study including the last 40 consecutive patients with TA (2004–2006) and the first 40 consecutive patients with AA (2006–2010) performed at our centre. Preoperative, surgical and postoperative data were prospectively collected until patient discharge.

Results

No preoperative differences were found. Overall postoperative morbidity was higher in the TA group (75  vs 47 %; p = 0.012). No significant differences in DGE were found (TA: 35 % vs AA: 20 %; p = 0.1). Termino-terminal pancreatic anastomosis, gastrostomy, prophylactic somatostatin and the presence of intra-abdominal collections were associated with DGE. On multivariate analysis, only intra-abdominal collections (OR: 4.95 % CI: 1.36–11.8; p = 0.012) predicted DGE. Among patients without other surgical complications (n = 46), DGE rate was significantly higher in the TA group (TA: 38 % vs AA: 12 %, p = 0.04).

Conclusions

Overall, no significant differences in DGE were found between groups. AA could be a protective factor for DGE when no other surgical complications appear.
Literature
1.
go back to reference Kawai M, Yamaue H. Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today. 2010;40:1011–7.PubMedCrossRef Kawai M, Yamaue H. Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today. 2010;40:1011–7.PubMedCrossRef
2.
go back to reference Mañas-Gómez MJ, Rodríguez-Revuelto R, Balsells-Valls J, et al. Post-pancreaticoduodenectomy hemorrhage. Incidence, diagnosis, and treatment. World J Surg. 2011;35:2543–8.PubMedCrossRef Mañas-Gómez MJ, Rodríguez-Revuelto R, Balsells-Valls J, et al. Post-pancreaticoduodenectomy hemorrhage. Incidence, diagnosis, and treatment. World J Surg. 2011;35:2543–8.PubMedCrossRef
3.
go back to reference Winter JM, Cameron JL, Campbell KA, et al. 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg. 2006;10:1199–211.PubMedCrossRef Winter JM, Cameron JL, Campbell KA, et al. 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg. 2006;10:1199–211.PubMedCrossRef
4.
go back to reference Malleo G, Crippa S, Butturini G, et al. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: validation of International Study Group of Pancreatic Surgery classification and analysis of risk factors. HPB. 2010;12:610–8.PubMedCentralPubMedCrossRef Malleo G, Crippa S, Butturini G, et al. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: validation of International Study Group of Pancreatic Surgery classification and analysis of risk factors. HPB. 2010;12:610–8.PubMedCentralPubMedCrossRef
5.
go back to reference Welsch T, Borm M, Degrate L, et al. Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre. Br J Surg. 2010;97:1043–50.PubMedCrossRef Welsch T, Borm M, Degrate L, et al. Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre. Br J Surg. 2010;97:1043–50.PubMedCrossRef
6.
go back to reference Park JS, Hwang HK, Kim JK, et al. Clinical validation and risk factors for delayed gastric emptying based on the International Study Group of Pancreatic Surgery (ISGPS) Classification. Surgery. 2009;146:882–7. Park JS, Hwang HK, Kim JK, et al. Clinical validation and risk factors for delayed gastric emptying based on the International Study Group of Pancreatic Surgery (ISGPS) Classification. Surgery. 2009;146:882–7.
7.
go back to reference Traverso LW, Hashimoto Y. Delayed gastric emptying: the state of the highest level of evidence. J Hepatobiliary Pancreat Surg. 2008;15:262–9.PubMedCrossRef Traverso LW, Hashimoto Y. Delayed gastric emptying: the state of the highest level of evidence. J Hepatobiliary Pancreat Surg. 2008;15:262–9.PubMedCrossRef
8.
go back to reference Butturini G, Marcucci S, Molinari E, et al. Complications after pancreaticoduodenectomy: the problem of current definitions. J Hepatobiliary Pancreat Surg. 2006;13:207–11.PubMedCrossRef Butturini G, Marcucci S, Molinari E, et al. Complications after pancreaticoduodenectomy: the problem of current definitions. J Hepatobiliary Pancreat Surg. 2006;13:207–11.PubMedCrossRef
9.
go back to reference Tan WJ, Kow AWC, Liau KH. Moving towards the New International Study Group for Pancreatic Surgery (ISGPS) definitions in pancreaticoduodenectomy: a comparison between the old and new. HPB. 2011;13:566–72.PubMedCentralPubMedCrossRef Tan WJ, Kow AWC, Liau KH. Moving towards the New International Study Group for Pancreatic Surgery (ISGPS) definitions in pancreaticoduodenectomy: a comparison between the old and new. HPB. 2011;13:566–72.PubMedCentralPubMedCrossRef
10.
go back to reference Wente MN, Bassi C, Dervenis C, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142:761–8.PubMedCrossRef Wente MN, Bassi C, Dervenis C, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142:761–8.PubMedCrossRef
11.
go back to reference Tanaka M. Gastroparesis after a pylorus-preserving pancreatoduodenectomy. Surg Today. 2005;35:345–50.PubMedCrossRef Tanaka M. Gastroparesis after a pylorus-preserving pancreatoduodenectomy. Surg Today. 2005;35:345–50.PubMedCrossRef
12.
go back to reference Dong K, Yu XJ, Li B, et al. Advances in mechanisms of postsurgical gastroparesis syndrome and its diagnosis and treatment. Chin J Dig Dis. 2006;7:76–82.PubMedCrossRef Dong K, Yu XJ, Li B, et al. Advances in mechanisms of postsurgical gastroparesis syndrome and its diagnosis and treatment. Chin J Dig Dis. 2006;7:76–82.PubMedCrossRef
13.
go back to reference Tanaka A, Ueno T, Oka M, et al. Effect of denervation of the pylorus and transection of the duodenum on acetaminophen absorption in rats; possible mechanism for early delayed gastric emptying after pylorus preserving pancreatoduodenectomy. Tohoku J Exp Med. 2000;192:239–47.PubMedCrossRef Tanaka A, Ueno T, Oka M, et al. Effect of denervation of the pylorus and transection of the duodenum on acetaminophen absorption in rats; possible mechanism for early delayed gastric emptying after pylorus preserving pancreatoduodenectomy. Tohoku J Exp Med. 2000;192:239–47.PubMedCrossRef
14.
go back to reference Räty S, Sand J, Lantto E, et al. Postoperative acute pancreatitis as a major determinant of postoperative delayed gastric emptying after pancreaticoduodenectomy. J Gastrointest Surg. 2006;10:1131–9.PubMedCrossRef Räty S, Sand J, Lantto E, et al. Postoperative acute pancreatitis as a major determinant of postoperative delayed gastric emptying after pancreaticoduodenectomy. J Gastrointest Surg. 2006;10:1131–9.PubMedCrossRef
15.
go back to reference Murakami H, Suzuki H, Nakamura T. Pancreatic fibrosis correlates with delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy with pancreaticogastrostomy. Ann Surg. 2002;235:240–5.PubMedCentralPubMedCrossRef Murakami H, Suzuki H, Nakamura T. Pancreatic fibrosis correlates with delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy with pancreaticogastrostomy. Ann Surg. 2002;235:240–5.PubMedCentralPubMedCrossRef
16.
go back to reference Sugiyama M, Abe N, Ueki H, et al. A new reconstruction method for preventing delayed gastric emptying after pylorus-preserving pancreatoduodenectomy. Am J Surg. 2004;187:743–6.PubMedCrossRef Sugiyama M, Abe N, Ueki H, et al. A new reconstruction method for preventing delayed gastric emptying after pylorus-preserving pancreatoduodenectomy. Am J Surg. 2004;187:743–6.PubMedCrossRef
17.
go back to reference Hartel M, Wente MN, Hinz U, et al. Effect of antecolic reconstruction on delayed gastric emptying after the pylorus-preserving Whipple procedure. Arch Surg. 2005;140:1094–9.PubMedCrossRef Hartel M, Wente MN, Hinz U, et al. Effect of antecolic reconstruction on delayed gastric emptying after the pylorus-preserving Whipple procedure. Arch Surg. 2005;140:1094–9.PubMedCrossRef
18.
go back to reference Tani M, Terasawa H, Kawai M, et al. Improvement of delayed gastric emptying in pylorus-preserving pancreaticoduodenectomy: results of a prospective, randomized, controlled trial. Ann Surg. 2006;243:316–20.PubMedCentralPubMedCrossRef Tani M, Terasawa H, Kawai M, et al. Improvement of delayed gastric emptying in pylorus-preserving pancreaticoduodenectomy: results of a prospective, randomized, controlled trial. Ann Surg. 2006;243:316–20.PubMedCentralPubMedCrossRef
19.
go back to reference Chijiiwa K, Imamura N, Ohuchida J, et al. Prospective randomized controlled study of gastric emptying assessed by (13)C-acetate breath test after pylorus-preserving pancreaticoduodenectomy: comparison between antecolic and vertical retrocolic duodenojejunostomy. J Hepatobiliary Pancreat Surg. 2009;16:49–55.PubMedCrossRef Chijiiwa K, Imamura N, Ohuchida J, et al. Prospective randomized controlled study of gastric emptying assessed by (13)C-acetate breath test after pylorus-preserving pancreaticoduodenectomy: comparison between antecolic and vertical retrocolic duodenojejunostomy. J Hepatobiliary Pancreat Surg. 2009;16:49–55.PubMedCrossRef
20.
go back to reference Gangavatiker R, Pal S, Javed A, et al. Effect of antecolic or retrocolic reconstruction of the gastro/duodenojejunostomy on delayed gastric emptying after pancreaticoduodenectomy: a randomized controlled trial. J Gastrointest Surg. 2011;15:843–52.PubMedCrossRef Gangavatiker R, Pal S, Javed A, et al. Effect of antecolic or retrocolic reconstruction of the gastro/duodenojejunostomy on delayed gastric emptying after pancreaticoduodenectomy: a randomized controlled trial. J Gastrointest Surg. 2011;15:843–52.PubMedCrossRef
21.
go back to reference Eshuis WJ, van Dalen JW, Busch OR, et al. Route of gastroenteric reconstruction in pancreatoduodenectomy and delayed gastric emptying. HPB. 2012;14:54–9.PubMedCentralPubMedCrossRef Eshuis WJ, van Dalen JW, Busch OR, et al. Route of gastroenteric reconstruction in pancreatoduodenectomy and delayed gastric emptying. HPB. 2012;14:54–9.PubMedCentralPubMedCrossRef
22.
go back to reference Eshuis WJ, van Eijck C, Gerhards MF, et al. Antecolic versus retrocolic route of the gastroenteric anastomosis after pancreatoduodenectomy. Ann Surg. 2014;259:45–51.PubMedCrossRef Eshuis WJ, van Eijck C, Gerhards MF, et al. Antecolic versus retrocolic route of the gastroenteric anastomosis after pancreatoduodenectomy. Ann Surg. 2014;259:45–51.PubMedCrossRef
23.
go back to reference Pedrazzoli S, Beger HG, Obertop H, et al. A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancer. Dig Surg. 1999;16:337–45.PubMedCrossRef Pedrazzoli S, Beger HG, Obertop H, et al. A surgical and pathological based classification of resective treatment of pancreatic cancer. Summary of an international workshop on surgical procedures in pancreatic cancer. Dig Surg. 1999;16:337–45.PubMedCrossRef
24.
go back to reference Busquets J, Fabregat J, Jorba R, et al. [Surgical treatment of pancreatic adenocarcinoma by cephalic duodenopancreatectomy (Part 1). Post-surgical complications in 204 cases in a reference hospital]. Cir Esp. 2010;88:299–307.PubMedCrossRef Busquets J, Fabregat J, Jorba R, et al. [Surgical treatment of pancreatic adenocarcinoma by cephalic duodenopancreatectomy (Part 1). Post-surgical complications in 204 cases in a reference hospital]. Cir Esp. 2010;88:299–307.PubMedCrossRef
25.
go back to reference Riediger H, Makowiec F, Schareck WD, et al. Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications. J Gastrointest Surg. 2003;7:758–65.PubMedCrossRef Riediger H, Makowiec F, Schareck WD, et al. Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications. J Gastrointest Surg. 2003;7:758–65.PubMedCrossRef
26.
go back to reference Kunstman JW, Fonseca AL, Ciarleglio MM, et al. Comprehensive analysis of variables affecting delayed gastric emptying following pancreaticoduodenectomy. J Gastrointest Surg. 2012;16:1354–1361.PubMedCrossRef Kunstman JW, Fonseca AL, Ciarleglio MM, et al. Comprehensive analysis of variables affecting delayed gastric emptying following pancreaticoduodenectomy. J Gastrointest Surg. 2012;16:1354–1361.PubMedCrossRef
27.
go back to reference Park Y-C, Kim S-W, Jang J-Y, et al. Factors influencing delayed gastric emptying after pylorus-preserving pancreatoduodenectomy. J Am Coll Surg. 2003;196:859–65.PubMedCrossRef Park Y-C, Kim S-W, Jang J-Y, et al. Factors influencing delayed gastric emptying after pylorus-preserving pancreatoduodenectomy. J Am Coll Surg. 2003;196:859–65.PubMedCrossRef
28.
go back to reference Kimura F, Suwa T, Sugiura T, et al. Sepsis delays gastric emptying following pylorus-preserving pancreaticoduodenectomy. Hepatogastroenterology. 2002;49:585–8.PubMed Kimura F, Suwa T, Sugiura T, et al. Sepsis delays gastric emptying following pylorus-preserving pancreaticoduodenectomy. Hepatogastroenterology. 2002;49:585–8.PubMed
29.
go back to reference Kurosaki I, Hatakeyama K. Clinical and surgical factors influencing delayed gastric emptying after pyloric-preserving pancreaticoduodenectomy. Hepatogastroenterology. 2005;52:143–8.PubMed Kurosaki I, Hatakeyama K. Clinical and surgical factors influencing delayed gastric emptying after pyloric-preserving pancreaticoduodenectomy. Hepatogastroenterology. 2005;52:143–8.PubMed
30.
go back to reference Shan Y-S, Hsieh Y-H, Sy ED, et al. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. J Formos Med Assoc. 2004;103:767–72.PubMed Shan Y-S, Hsieh Y-H, Sy ED, et al. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. J Formos Med Assoc. 2004;103:767–72.PubMed
Metadata
Title
Antecolic anastomosis and delayed gastric emptying: still a benefit in patients without intra-abdominal complications?
Authors
M. Beisani, MD
C. Dopazo, MD, PhD
L. Blanco, MD
M. Caralt, MD
G. Sapisochín, MD, PhD
J-J Olsina, MD, PhD
J. Balsells, MD, PhD
Publication date
01-06-2015
Publisher
Springer Vienna
Published in
European Surgery / Issue 3/2015
Print ISSN: 1682-8631
Electronic ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-015-0311-2

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