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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 5/2007

01-05-2007

Telomerase Activity is a Prognostic Factor for Recurrence and Survival in Rectal Cancer

Authors: Cristina Valls Bautista, B.S., Carme Piñol Felis, M.D., Josep M. Reñé Espinet, M.D., Juan Buenestado García, M.D., Joan Viñas Salas, M.D.

Published in: Diseases of the Colon & Rectum | Issue 5/2007

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Purpose

This study was designed to determine whether telomerase activity measured in samples of tumoral tissue, transitional mucosa, and normal mucosa from patients with sporadic colorectal cancer is a prognostic factor for recurrence and overall survival.

Methods

Telomerase activity was determined by fluorescence-based telomeric repeat amplification in tissue samples from 108 patients with sporadic colorectal cancer. A telomerase index was determined by using the formula log (telomerase activity of cancer tissue – telomerase activity of normal mucosa).

Results

Mean telomerase activity in tumoral tissue was 11.49 (total product generated), in transitional mucosa it was 1.51, and in normal mucosa it was 1.09 (P < 0.001). Telomerase activity and telomerase index were not correlated with clinicopathologic factors. Rectal cancer patients’ recurrence-free survival was related to N classification (P = 0.004) and to tumor-node-metastases stage classification (P = 0.023) and telomerase index 0.85 (P = 0.023). Overall survival was associated with N classification (positive/negative) and telomerase index (≤0.85 or >0.85; P = 0.018 and P = 0.011, respectively).

Conclusions

Measurement of telomerase activity has a diagnostic value in colorectal patients. In rectal cancer, telomerase index is an independent prognostic factor for disease progression. A telomerase index≤0.85 and negative nodes can be used to predict disease progression.
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Metadata
Title
Telomerase Activity is a Prognostic Factor for Recurrence and Survival in Rectal Cancer
Authors
Cristina Valls Bautista, B.S.
Carme Piñol Felis, M.D.
Josep M. Reñé Espinet, M.D.
Juan Buenestado García, M.D.
Joan Viñas Salas, M.D.
Publication date
01-05-2007
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 5/2007
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-006-0820-y

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