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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 12/2006

01-12-2006 | Case Reports

Complete Closure of Cancer-Related Anovaginal and Anoperineal Fistulas in Locally Advanced Anal Canal Carcinomas by Upfront Intra-Arterial Chemotherapy Followed by Combined Radiochemotherapy: Report of Two Cases

Authors: L. Rosset, M.D., A. S. Allal, M.D., P. Morel, M.D., B. Roche, M.D., A. D. Roth, M.D.

Published in: Diseases of the Colon & Rectum | Issue 12/2006

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Purpose

Cancer-related fistulas are a major problem in locally advanced anal canal carcinoma, because conservative radiochemotherapy may not be recommended in this setting. Therefore, it is usually recommended to proceed to an abdominoperineal resection with definitive colostomy in the presence of such lesions.

Methods

Because chemotherapy can lead to closure of cancer-related fistulas and local intra-arterial chemotherapy is effective in locally advanced anal canal cancer, we treated two anal canal carcinoma patients presenting with cancer-related fistulas with upfront intra-arterial chemotherapy followed by radiochemotherapy, leading to complete closure of fistulas.

Results

Both patients are free of colostomy and in complete remission after more than four years of follow-up.

Conclusions

This conservative approach combining local intra-arterial chemotherapy and standard radiochemotherapy is feasible and should be considered in the management of such locally advanced anal canal carcinoma.
Literature
1.
Anonymous,  1996Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5-fluorouracil and mitomycin. UKCCCR anal cancer trial working partyLancet34810491054CrossRef
2.
Bartelink, H, Roelofsen, F, Eschwege, F,  et al. 1997Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European organization for research and treatment of cancer radiotherapy and gastrointestinal cooperative groupsJ Clin Oncol1520402049PubMed
3.
Flam, M, John, M, Pajak, M,  et al. 1996Role of mitomycin in combination with fluorouracil and radiotherapy and of salvage chemoradiation in the definitive non surgical treatment of epidermoid carcinoma of the anal canal: result of a phase III randomised intergroup studyJ Clin Oncol1425272539PubMed
4.
Malik, SM, Krasnow, SH, Wadleigh, RG 1994Closure of tracheoesophageal fistulas with primary chemotherapy in patients with esophageal cancerCancer7313211323PubMedCrossRef
5.
Ahmed, HF, Hussain, MA, Grant, CE, Wadleigh, RG 1998Closure of tracheoesophageal fistulas with chemotherapy and radiotherapyAm J Clin Oncol21177179PubMedCrossRef
6.
Muto, M, Ohtsu, A, Miyamoto, S,  et al. 1999Concurrent chemoradiotherapy for esophageal carcinoma patients with malignant fistulaeCancer8614061413PubMedCrossRef
7.
Ranganathan, V 1995Esophageal carcinoma with a sinus tract: closure of the tract with primary chemotherapy and radiation therapyAm J Gastroenterol9019031904PubMed
8.
Hoshi, S, Shintaku, I, Suzuki, K,  et al. 2000Bladder preservation by internal iliac arterial infusion chemotherapy and irradiation in T3 bladder carcinoma patients over the age of 70 yearsTohoku J Exp Med192249258PubMedCrossRef
9.
Damascelli, B, Cantu, G, Mattavelli, F,  et al. 2001Intra-arterial chemotherapy with polyoethylated castor oil free paclitaxel incorporated in albumin nanoparticles: phase I study of patients with squamous cell carcinoma of the head and neck and anal canal: preliminary evidence of clinical activityCancer9225922602PubMedCrossRef
10.
Fischerman, K, Briand, P, Olsen, J, Nielsen, OV 1974Intra-arterial combined cancer chemotherapy in technically inoperable carcinoma of the anus and rectumActa Chir Scand140416421PubMed
11.
Wang, HM, Ng, SH, Wang, CH,  et al. 2001Intra-arterial plus iv chemotherapy for advanced bulky squamous cell carcinoma of the buccal mucosaAnticancer Drugs12331337PubMedCrossRef
12.
Maeda, K, Hashimoto, M, Yamamoto, O,  et al. 1994A case of fistula-cancer response to arterial chemoembolizationGan To Kagaku Ryoho2123412344PubMed
13.
Roth, AD, Berney, CR, Rohner, S,  et al. 2000Intra-arterial chemotherapy in locally advanced or recurrent carcinomas of the penis and anal canal: an active treatment modality with curative potentialBr J Cancer8316371642PubMedCrossRef
14.
Manivit, P, Polo, R, Tabary, D,  et al. 1995Initial locoregional chemotherapy in recurrent and locoregional advanced or inoperable stages of pelvic uterine and anorectal cancersBull Cancer82137148PubMed
15.
Haas, G, Blumenstein, BA, Gagliano, RG,  et al. 1999Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a southwest oncology group studyJ Urol16118231825PubMedCrossRef
Metadata
Title
Complete Closure of Cancer-Related Anovaginal and Anoperineal Fistulas in Locally Advanced Anal Canal Carcinomas by Upfront Intra-Arterial Chemotherapy Followed by Combined Radiochemotherapy: Report of Two Cases
Authors
L. Rosset, M.D.
A. S. Allal, M.D.
P. Morel, M.D.
B. Roche, M.D.
A. D. Roth, M.D.
Publication date
01-12-2006
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 12/2006
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-006-0721-0

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