Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 9/2006

01-09-2006

Differential Prognostic Significance of Morphologic Invasive Markers in Colorectal Cancer: Tumor Budding and Cytoplasmic Podia

Authors: Eiji Shinto, M.D., Jeremy R. Jass, M.D., Hitoshi Tsuda, M.D., Taichi Sato, M.D., Hideki Ueno, M.D., Kazuo Hase, M.D., Hidetaka Mochizuki, M.D., Osamu Matsubara, M.D.

Published in: Diseases of the Colon & Rectum | Issue 9/2006

Login to get access

Purpose

In colorectal cancer, the presence of cytoplasmic podia around tumor budding foci may be a morphologic marker for an activated budding phenotype that is associated with cell motility. In this study, we have investigated the prognostic significance of cytoplasmic podia.

Methods

A total of 136 pT3 colorectal cancers were classified according to extent of budding and cytoplasmic podia as identified by immunostaining for cytokeratin. The prognostic significance of budding and cytoplasmic podia was then assessed.

Results

The overall survival curves between the groups with high-grade and low-grade cytoplasmic podia were different (5-year survival rates were 60.5 and 83.8 percent respectively, P = 0.0003). Similar results were shown for tumor budding (59.8 and 87.7 percent, P < 0.0001). Multivariate analysis showed that the grades of cytoplasmic podia (hazards ratio, 2.4; P = 0.012) and budding (hazards ratio, 2.3; P = 0.024) were independent prognostic factors. Additionally, among colorectal cancers with high-grade budding, the grade of cytoplasmic podia was selected as an independent prognostic factor (hazards ratio, 2.4; P = 0.042).

Conclusions

Cytoplasmic podia and budding are related but independent pathologic predictive markers in patients with resected pT3 colorectal cancer.
Literature
1.
Ueno, H, Murphy, J, Jass, JR, Mochizuki, H, Talbot, IC 2002Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancerHistopathology40127132PubMedCrossRef
2.
Hase, K, Shatney, C, Johnson, D, Trollope, M, Vierra, M 1993Prognostic value of tumor “budding” in patients with colorectal cancerDis Colon Rectum36627635PubMedCrossRef
3.
Tanaka, M, Hashiguchi, Y, Ueno, H, Hase, K, Mochizuki, H 2003Tumor budding at the invasive margin can predict patients at high risk of recurrence after curative surgery for stage II, T3 colon cancerDis Colon Rectum4610541059PubMedCrossRef
4.
Jass, JR, Barker, M, Fraser, L,  et al. 2003APC mutation and tumour budding in colorectal cancerJ Clin Pathol566973PubMedCrossRef
5.
Okuyama, T, Oya, M, Ishikawa, H 2003Budding as a useful prognostic marker in pT3 well- or moderately-differentiated rectal adenocarcinomaJ Surg Oncol834247PubMedCrossRef
6.
Shinto, E, Mochizuki, H, Ueno, H, Matsubara, O, Jass, JR 2005A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic fragments around budding fociHistopathology472531PubMedCrossRef
7.
Muller, T, Bain, G, Wang, X, Papkoff, J 2002Regulation of epithelial cell migration and tumor formation by beta-catenin signalingExp Cell Res280119133PubMedCrossRef
8.
Conacci-Sorrell, ME, Ben-Yedidia, T, Shtutman, M, Feinstein, E, Einat, P, Ben-Ze'ev, A 2002Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanomaGenes Dev1620582072PubMedCrossRef
9.
Tsalis, K, Vasiliadis, K, Christoforidis, E,  et al. 2004Current treatment of colorectal liver metastasesTech Coloproctol8174176CrossRef
10.
Berber, E, Pelley, R, Siperstein, AE 2005Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver: a prospective studyJ Clin Oncol2313581364PubMedCrossRef
11.
Allen-Mersh, TG, Earlam, S, Fordy, C, Abrams, K, Houghton, J 1994Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastasesLancet34412551260PubMedCrossRef
12.
Sobin, LHWittekind, CH eds. 1997UICC TNM classification of malignant tumours5Wiley-LissNew York
13.
Kaplan, E, Meier, P 1958Nonparametric estimation from incomplete observationsJ Am Stat Assoc53457481CrossRef
14.
Mantel, N 1966Evaluation of surgical data and two new rank order statistics arising in its considerationCancer50163170
15.
Cox, DR 1972Regression models and life-tablesJ R Stat Soc Ser B34187220
Metadata
Title
Differential Prognostic Significance of Morphologic Invasive Markers in Colorectal Cancer: Tumor Budding and Cytoplasmic Podia
Authors
Eiji Shinto, M.D.
Jeremy R. Jass, M.D.
Hitoshi Tsuda, M.D.
Taichi Sato, M.D.
Hideki Ueno, M.D.
Kazuo Hase, M.D.
Hidetaka Mochizuki, M.D.
Osamu Matsubara, M.D.
Publication date
01-09-2006
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 9/2006
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-006-0595-1

Other articles of this Issue 9/2006

Diseases of the Colon & Rectum 9/2006 Go to the issue

OriginalPaper

Survival in Colorectal Cancer Patients With Urinary Tract Invasion

OriginalPaper

Gracilis Muscle Transposition for Fistulas Between the Rectum and Urethra or Vagina

OriginalPaper

Management of Diverticulitis in Younger Patients

Letters to the Editor

The Passing of the United Ostomy Association

OriginalPaper

Management of Acute Diverticulitis in the East Anglian Region: Results of a United Kingdom Regional Survey

Technical Notes

Transperineal Repair of Persistent Rectovaginal Fistulas Using an Acellular Cadaveric Dermal Graft (AlloDerm®)