Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 11/2006

01-11-2006

Inhibitory Effects and Mechanisms of Colonic Electric Stimulation on Gastric and Rectal Tone in Conscious Dogs

Authors: Shi Liu, M.D., Yong Lei, M.D., J. D. Z. Chen, Ph.D.

Published in: Diseases of the Colon & Rectum | Issue 11/2006

Login to get access

Purpose

Colonic electric stimulation has been shown to alter motor functions of the colon; however, its effects on other organs of the gut have been investigated rarely.

Methods

This study was performed in 12 dogs implanted with one pair of colonic serosal electrodes and a gastric cannula. Experiments were performed to study: 1) the effect of colonic electric stimulation on proximal gastric tone and compliance; 2) the effect of colonic electric stimulation on rectal tone and compliance; 3) the sympathetic mechanism involved in the effects of colonic electric stimulation on gastric/rectal tone. A computerized barostat was used to assess gastric/rectal tone and compliance.

Results

Colonic electric stimulation inhibited both gastric and rectal tone with a higher potency in gastric tone. Colonic electric stimulation reduced gastric but not rectal compliance. The inhibitory effect of colonic electric stimulation on gastric tone but not rectal tone was abolished by an adrenergic blockade, guanethidine.

Conclusions

Colonic electric stimulation inhibits both gastric and rectal tone with a higher potency in inhibiting gastric tone. Colonic electric stimulation reduces gastric but not rectal compliance. The inhibitory effect of colonic electric stimulation on gastric tone seems to be mediated by the sympathetic pathway.
Literature
1.
Schang, JC, Devroede, G 1983Fasting and postprandial myoelectric spiking activity in the human sigmoid colonGastroenterology8510481053PubMed
2.
Dapoigny, M, Trolese, JF, Bommelaer, G, Tournut, R 1988Myoelectric spiking activity of right colon, left colon, and rectosigmoid of healthy humansDig Dis Sci3310071012PubMedCrossRef
3.
Frexinos, J, Bueno, L, Fioramonti, J 1985Diurnal changes in myoelectric spiking activity of the human colonGastroenterology8811041110PubMed
4.
Garcia, D, Hita, G, Mompean, B,  et al. 1991Colonic motility: electric and manometric description of mass movementDis Colon Rectum34577584PubMedCrossRef
5.
Shafik, A 1998Electrosigmoidogram in the various pathologic conditions of the sigmoid colonFront Biosci3B11B14PubMed
6.
Bassotti, G, Morelli, A, Whitehead, WE 1992Abnormal rectosigmoid myoelectric response to eating in patients with severe idiopathic constipation (slow-transit type)Dis Colon Rectum35753756PubMedCrossRef
7.
Shafik, A, Shafik, AA, El-Sibai, O, Ahmed, I 2003Colonic pacing in patients with constipation due to colonic inertiaMed Sci Monit9CR191CR196PubMed
8.
Bruninga, K, Riedy, L, Keshavarzian, A, Walter, J 1998The effect of electrical stimulation on colonic transit following spinal cord injury in catsSpinal Cord36847853PubMedCrossRef
9.
Shafik, A, El-Sibai, O, Shafik, AA, Ahmed, I 2003Colonic pacing in the treatment of patients with irritable bowel syndrome: technique and resultsFront Biosci8b1b5PubMed
10.
Kerlin, P, Zinsmeister, A, Phillips, S 1983Motor responses to food of the ileum, proximal colon, and distal colon of healthy humansGastroenterology84762770PubMed
11.
Bampton, PA, Dinning, PG, Kennedy, ML, Lubowski, DZ, Cook, IJ 2002The proximal colonic motor response to rectal mechanical and chemical stimulationAm J Physiol Gastrointest Liver Physiol282G443G449PubMed
12.
Shafik, A, El-Sibai, O 2000Esophageal and gastric motile response to rectal distension with identification of a recto-esophagogastric reflexInt J Surg Investig1373379PubMed
13.
Zhao, XT, Wang, LJ, Chen, JD 2003Sustained inhibitory effects of intestinal electric stimulation on intestinal motility in conscious dogs (abstract)Gastroenterology124S1145
14.
Fritz, E, Hammer, J, Schmidt, B, Eherer, AJ, Hammer, HF 2003Stimulation of the nitric oxide-guanosine 3′, 5′-cyclic monophosphate pathway by sildenafil: effect on rectal muscle tone, distensibility, and perception in health and in irritable bowel syndromeAm J Gastroenterol9822532260PubMed
15.
Malcolm, A, Phillips, SF, Camilleri, M, Hanson, RB 1997Pharmacological modulation of rectal tone alters perception of distention in humansAm J Gastroenterol9220732079PubMed
16.
Shafik, A 2004Colonic pacing in the control of colonic and rectal motile activityDis Colon Rectum47545546PubMedCrossRef
17.
Shafik, A, Shafik, AA, El-Sibai, O, Ahmed, I 2004Colonic pacing: a therapeutic option for the treatment of constipation due to total colonic inertiaArch Surg139775779PubMedCrossRef
18.
Furness, JB, Costa, M 1978Sympathetic influences on gastrointestinal functionFurness, JBCosta, M eds. The enteric nervous systemChurchill LivingstoneEdinburgh207238
19.
Tack, J, Piessevaux, H, Coulie, B, Caenepeel, P, Janssens, J 1998Role of impaired gastric accommodation to a meal in functional dyspepsiaGastroenterology11513461352PubMedCrossRef
20.
Moragas, G, Azpiroz, F, Pavia, J, Malagelada, JR 1993Relations among intragastric pressure, postcibal perception, and gastric emptyingAm J Physiol264G1112G1117PubMed
21.
Rasmussen, OO, Ronholt, C, Alstrup, N, Christiansen, J 1998Anorectal pressure gradient and rectal compliance in fecal incontinenceInt J Colorectal Dis13157159PubMedCrossRef
Metadata
Title
Inhibitory Effects and Mechanisms of Colonic Electric Stimulation on Gastric and Rectal Tone in Conscious Dogs
Authors
Shi Liu, M.D.
Yong Lei, M.D.
J. D. Z. Chen, Ph.D.
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 11/2006
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-006-0586-2

Other articles of this Issue 11/2006

Diseases of the Colon & Rectum 11/2006 Go to the issue

OriginalPaper

A National Study on Lymph Node Retrieval in Resectional Surgery for Colorectal Cancer

Letters to the Editor

An Evidence-Based Review on Surveillance for Lynch Syndrome

Letters to the Editor

The Authors Reply

OriginalPaper

Botulinum Toxin vs. Topical Glyceryl Trinitrate Ointment for Pain Control in Patients Undergoing Hemorrhoidectomy: A Randomized Trial

Original Contributions

Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer

Report

Coloseminal Vesicle Fistula: Report of a Case and Review of the Literature