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Diseases of the Colon & Rectum
Published in: Diseases of the Colon & Rectum 7/2004

01-07-2004 | Original Contribution

Carbohydrate-Electrolyte (E-Lyte®) Solution Enhances Bowel Preparation With Oral Fleet® Phospho-soda®

Authors: Joe J. Tjandra, M.D., F.R.A.C.S., Peter Tagkalidis, M.B.B.S., F.R.A.C.P.

Published in: Diseases of the Colon & Rectum | Issue 7/2004

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PURPOSE:

Bowel preparation with oral sodium phosphate can cause symptomatic dehydration and electrolyte disturbances. This randomized, controlled trial was designed to evaluate whether carbohydrate-electrolyte (E-Lyte®) solution enhanced bowel preparation and improved patient acceptance with oral sodium phosphate.

METHODS:

A total of 187 consecutive adults undergoing colonoscopy by two endoscopists were randomized to receive two packets of oral sodium phosphate (Fleet® Phospho-soda®) with or without additional supplement of a carbohydrate-electrolyte (E-Lyte®) solution. All patients and endoscopists completed a standardized questionnaire. Urine-specific gravity and serum biochemistry were randomly performed in 150 and 50 patients, respectively.

RESULTS:

Ninety patients were randomized to have oral sodium phosphate with E-Lyte® supplements (Group 1) and 94 patients to sodium phosphate without E-Lyte® supplements (Group 2). The groups were similar in age and gender, indication for colonoscopy, and previous colonic surgery. Patients taking E-Lyte® supplement had significantly less dizziness (none, 80 vs. 56 percent; P < 0.001) and a trend toward less nausea (none, 70 vs. 56 percent; P = 0.05). All patients in Group 1 completed the bowel preparation as opposed to 3 percent of Group 2 being unable to complete the preparation. Hypokalemia was significantly more frequent (P = 0.008) in Group 2 patients without E-Lyte® supplements. More patients in Group 2 needed intravenous rehydration (11 vs. 4 percent). Differences in serum creatinine and urine-specific gravity suggested possibly a lesser degree of hypovolemia in patients taking E-Lyte® supplements. The quality of bowel cleansing in patients taking E-Lyte® supplements was considered better by both the endoscopists and patients.

CONCLUSIONS:

Carbohydrate-electrolyte (E-Lyte®) solution protects against hypokalemia, improves patient tolerability, and may enhance use of oral sodium phosphate as a bowel-preparation agent.
Literature
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Metadata
Title
Carbohydrate-Electrolyte (E-Lyte®) Solution Enhances Bowel Preparation With Oral Fleet® Phospho-soda®
Authors
Joe J. Tjandra, M.D., F.R.A.C.S.
Peter Tagkalidis, M.B.B.S., F.R.A.C.P.
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
Diseases of the Colon & Rectum / Issue 7/2004
Print ISSN: 0012-3706
Electronic ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-004-0559-2

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