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Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 2/2019

Open Access 01-04-2019 | Research Article

Short-acquisition-time JPRESS and its application to paediatric brain tumours

Authors: Dominic Carlin, Ben Babourina-Brooks, Theodoros N. Arvanitis, Martin Wilson, Andrew C. Peet

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 2/2019

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Abstract

Objective

To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla.

Materials and methods

The short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS.

Results

Metabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer–Rao lower bounds > 50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS.

Conclusion

A 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest.
Appendix
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Metadata
Title
Short-acquisition-time JPRESS and its application to paediatric brain tumours
Authors
Dominic Carlin
Ben Babourina-Brooks
Theodoros N. Arvanitis
Martin Wilson
Andrew C. Peet
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 2/2019
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-018-0716-6

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Acknowledgement

Acknowledgement to reviewers 2018