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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-06-2016 | Research Article

A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field

Authors: Matthew John Cronin, Samuel Wharton, Ali Al-Radaideh, Cris Constantinescu, Nikos Evangelou, Richard Bowtell, Penny Anne Gowland

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2016

Abstract

Objective

The aim of this study was to compare the use of high-resolution phase and QSM images acquired at ultra-high field in the investigation of multiple sclerosis (MS) lesions with peripheral rings, and to discuss their usefulness for drawing inferences about underlying tissue composition.

Materials and methods

Thirty-nine Subjects were scanned at 7 T, using 3D T ₂*-weighted and T ₁-weighted sequences. Phase images were then unwrapped and filtered, and quantitative susceptibility maps were generated using a thresholded k-space division method. Lesions were compared visually and using a 1D profiling algorithm.

Results

Lesions displaying peripheral rings in the phase images were identified in 10 of the 39 subjects. Dipolar projections were apparent in the phase images outside of the extent of several of these lesions; however, QSM images showed peripheral rings without such projections. These projections appeared ring-like in a small number of phase images where no ring was observed in QSM. 1D profiles of six well-isolated example lesions showed that QSM contrast corresponds more closely to the magnitude images than phase contrast.

Conclusions

Phase images contain dipolar projections, which confounds their use in the investigation of tissue composition in MS lesions. Quantitative susceptibility maps correct these projections, providing insight into the composition of MS lesions showing peripheral rings.

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Title: A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field
Authors: Matthew John Cronin
Samuel Wharton
Ali Al-Radaideh
Cris Constantinescu
Nikos Evangelou
Richard Bowtell
Penny Anne Gowland
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2016
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-016-0560-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field

Abstract

Objective

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

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