Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 3/2016

01-06-2016 | Research Article

Robust imaging of hippocampal inner structure at 7T: in vivo acquisition protocol and methodological choices

Authors: Linda Marrakchi-Kacem, Alexandre Vignaud, Julien Sein, Johanne Germain, Thomas R. Henry, Cyril Poupon, Lucie Hertz-Pannier, Stéphane Lehéricy, Olivier Colliot, Pierre-François Van de Moortele, Marie Chupin

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2016

Login to get access

Abstract

Objective

Motion-robust multi-slab imaging of hippocampal inner structure in vivo at 7T.

Materials and methods

Motion is a crucial issue for ultra-high resolution imaging, such as can be achieved with 7T MRI. An acquisition protocol was designed for imaging hippocampal inner structure at 7T. It relies on a compromise between anatomical details visibility and robustness to motion. In order to reduce acquisition time and motion artifacts, the full slab covering the hippocampus was split into separate slabs with lower acquisition time. A robust registration approach was implemented to combine the acquired slabs within a final 3D-consistent high-resolution slab covering the whole hippocampus. Evaluation was performed on 50 subjects overall, made of three groups of subjects acquired using three acquisition settings; it focused on three issues: visibility of hippocampal inner structure, robustness to motion artifacts and registration procedure performance.

Results

Overall, T2-weighted acquisitions with interleaved slabs proved robust. Multi-slab registration yielded high quality datasets in 96 % of the subjects, thus compatible with further analyses of hippocampal inner structure.

Conclusion

Multi-slab acquisition and registration setting is efficient for reducing acquisition time and consequently motion artifacts for ultra-high resolution imaging of the inner structure of the hippocampus.
Literature
1.
Zeidman P, Lutti A, Maguire EA (2015) Investigating the functions of subregions within anterior hippocampus. Cortex J Devoted Study Nerv Syst Behav 73:240–256CrossRef
2.
Robinson JL, Barron DS, Kirby LAJ, Bottenhorn KL, Hill AC, Murphy JE, Katz JS, Salibi N, Eickhoff SB, Fox PT (2015) Neurofunctional topography of the human hippocampus. Hum Brain Mapp 36:5018–5037CrossRefPubMed
3.
4.
Jack CR, Petersen RC, O’Brien PC, Tangalos EG (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42:183–188CrossRefPubMed
5.
Laakso MP, Partanen K, Riekkinen P, Lehtovirta M, Helkala EL, Hallikainen M, Hanninen T, Vainio P, Soininen H (1996) Hippocampal volumes in Alzheimer’s disease, Parkinson’s disease with and without dementia, and in vascular dementia: an MRI study. Neurology 46:678–681CrossRefPubMed
6.
Colliot O, Chételat G, Chupin M, Desgranges B, Magnin B, Benali H, Dubois B, Garnero L, Eustache F, Lehéricy S (2008) Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology 248:194–201CrossRefPubMed
7.
Jack CR, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH (2011) Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc 7:257–262CrossRef
8.
Engel J Jr (2001) Mesial temporal lobe epilepsy: what have we learned? Neurosci Rev J Bringing Neurobiol Neurol Psychiatry 7:340–352
9.
Maruszak A, Thuret S (2014) Why looking at the whole hippocampus is not enough-a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer’s disease diagnosis. Front Cell Neurosci 8:95CrossRefPubMedPubMedCentral
10.
La Joie R, Fouquet M, Mézenge F, Landeau B, Villain N, Mevel K, Pélerin A, Eustache F, Desgranges B, Chételat G (2010) Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence. NeuroImage 53:506–514CrossRefPubMed
11.
Winterburn JL, Pruessner JC, Chavez S, Schira MM, Lobaugh NJ, Voineskos AN, Chakravarty MM (2013) A novel in vivo atlas of human hippocampal subfields using high-resolution 3T magnetic resonance imaging. NeuroImage 74:254–265CrossRefPubMed
12.
Mueller SG, Stables L, Du AT, Schuff N, Truran D, Cashdollar N, Weiner MW (2007) Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Neurobiol Aging 28:719–726CrossRefPubMedPubMedCentral
13.
Mueller SG, Laxer KD, Barakos J, Cheong I, Garcia P, Weiner MW (2009) Subfield atrophy pattern in temporal lobe epilepsy with and without mesial sclerosis detected by high-resolution MRI at 4 Tesla: preliminary results. Epilepsia 50:1474–1483CrossRefPubMedPubMedCentral
14.
15.
Malykhin NV, Lebel RM, Coupland NJ, Wilman AH, Carter R (2010) In vivo quantification of hippocampal subfields using 4.7T fast spin echo imaging. NeuroImage 49:1224–1230CrossRefPubMed
16.
Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW (2010) Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer’s disease. Hum Brain Mapp 31:1339–1347CrossRefPubMedPubMedCentral
17.
Yushkevich PA, Wang H, Pluta J, Das SR, Craige C, Avants BB, Weiner MW, Mueller S (2010) Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI. NeuroImage 53:1208–1224CrossRefPubMedPubMedCentral
18.
Thomas BP, Welch EB, Niederhauser BD, Whetsell WO Jr, Anderson AW, Gore JC, Avison MJ, Creasy JL (2008) High-resolution 7T MRI of the human hippocampus in vivo. J Magn Reson Imaging 28:1266–1272CrossRefPubMedPubMedCentral
19.
Prudent V, Kumar A, Liu S, Wiggins G, Malaspina D, Gonen O (2010) Human hippocampal subfields in young adults at 7.0 T: feasibility of imaging. Radiology 254:900–906CrossRefPubMedPubMedCentral
20.
Wisse LEM, Gerritsen L, Zwanenburg JJM, Kuijf HJ, Luijten PR, Biessels GJ, Geerlings MI (2012) Subfields of the hippocampal formation at 7T MRI: in vivo volumetric assessment. NeuroImage 61:1043–1049CrossRefPubMed
21.
Goubran M, Rudko DA, Santyr B, Gati J, Szekeres T, Peters TM, Khan AR (2013) In vivo normative atlas of the hippocampal subfields using multi-echo susceptibility imaging at 7 Tesla. Hum Brain Mapp. doi:10.​1002/​hbm.​22423 PubMed
22.
Theysohn JM, Kraff O, Maderwald S, Schlamann MU, de Greiff A, Forsting M, Ladd SC, Ladd ME, Gizewski ER (2009) The human hippocampus at 7T—in vivo MRI. Hippocampus 19:1–7CrossRefPubMed
23.
Henry TR, Chupin M, Lehéricy S, Strupp JP, Sikora MA, Sha ZY, Ugurbil K, Van de Moortele P-F (2011) Hippocampal sclerosis in temporal lobe epilepsy: findings at 7T1. Radiology 261:199–209CrossRefPubMedPubMedCentral
24.
Kerchner GA, Deutsch GK, Zeineh M, Dougherty RF, Saranathan M, Rutt BK (2012) Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer’s disease. NeuroImage 63:194–202CrossRefPubMedPubMedCentral
25.
Kerchner GA, Bernstein JD, Fenesy MC, Deutsch GK, Saranathan M, Zeineh MM, Rutt BK (2013) Shared vulnerability of two synaptically-connected medial temporal lobe areas to age and cognitive decline: a seven tesla magnetic resonance imaging study. J Neurosci Off J Soc Neurosci 33:16666–16672CrossRef
26.
Wisse LEM, Biessels GJ, Heringa SM, Kuijf HJ, Koek DHL, Luijten PR, Geerlings MI, Utrecht Vascular Cognitive Impairment (VCI) Study Group (2014) Hippocampal subfield volumes at 7T in early Alzheimer’s disease and normal aging. Neurobiol Aging 35:2039–2045CrossRefPubMed
27.
Boutet C, Chupin M, Lehéricy S, Marrakchi-Kacem L, Epelbaum S, Poupon C, Wiggins C, Vignaud A, Hasboun D, Defontaines B, Hanon O, Dubois B, Sarazin M, Hertz-Pannier L, Colliot O (2014) Detection of volume loss in hippocampal layers in Alzheimer’s disease using 7T MRI: a feasibility study. NeuroImage Clin 5:341–348CrossRefPubMedPubMedCentral
28.
Duvernoy HM (2005) The human hippocampus, 3rd edn. Springer, Berlin, Heidelberg, pp 5–36
29.
Van Leemput K, Bakkour A, Benner T, Wiggins G, Wald LL, Augustinack J, Dickerson BC, Golland P, Fischl B (2009) Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. Hippocampus 19:549–557CrossRefPubMedPubMedCentral
30.
Kerchner GA, Hess CP, Hammond-Rosenbluth KE, Xu D, Rabinovici GD, Kelley DAC, Vigneron DB, Nelson SJ, Miller BL (2010) Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI. Neurology 75:1381–1387CrossRefPubMedPubMedCentral
31.
Hasboun D, Chantôme M, Zouaoui A, Sahel M, Deladoeuille M, Sourour N, Duyme M, Baulac M, Marsault C, Dormont D (1996) MR determination of hippocampal volume: comparison of three methods. AJNR Am J Neuroradiol 17:1091–1098PubMed
32.
Mugler JP, Bao S, Mulkern RV, Guttmann CRG, Robertson RL, Jolesz FA, Brookeman JR (2000) Optimized single-slab three-dimensional spin-echo MR imaging of the brain. Radiology 216:891–899CrossRefPubMed
33.
Massire A, Vignaud A, Robert B, Le Bihan D, Boulant N, Amadon A (2014) Parallel-transmission-enabled three-dimensional T2-weighted imaging of the human brain at 7 Tesla. Magn Reson Med Off J Soc Magn Reson Med Soc Magn Reson Med. doi:10.​1002/​mrm.​25353
34.
Eggenschwiler F, O’Brien KR, Gruetter R, Marques JP (2014) Improving T2-weighted imaging at high field through the use of kT-points. Magn Reson Med Off J Soc Magn Reson Med Soc Magn Reson Med 71:1478–1488CrossRef
Metadata
Title
Robust imaging of hippocampal inner structure at 7T: in vivo acquisition protocol and methodological choices
Authors
Linda Marrakchi-Kacem
Alexandre Vignaud
Julien Sein
Johanne Germain
Thomas R. Henry
Cyril Poupon
Lucie Hertz-Pannier
Stéphane Lehéricy
Olivier Colliot
Pierre-François Van de Moortele
Marie Chupin
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2016
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-016-0552-5

Other articles of this Issue 3/2016

Magnetic Resonance Materials in Physics, Biology and Medicine 3/2016 Go to the issue

Research Article

Electrodynamics and radiofrequency antenna concepts for human magnetic resonance at 23.5 T (1 GHz) and beyond

Research Article

Correction of B 0-induced geometric distortion variations in prospective motion correction for 7T MRI

Research Article

3D T 2-weighted imaging at 7T using dynamic kT-points on single-transmit MRI systems

Research Article

Pulsed arterial spin labelling at ultra-high field with a B 1 + -optimised adiabatic labelling pulse

Research Article

High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI

Research Article

Technical feasibility of integrating 7 T anatomical MRI in image-guided radiotherapy of glioblastoma: a preparatory study