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Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 1/2016

01-02-2016 | Research Article

DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model versus shutter-speed model—initial experience

Authors: Guido H. Jajamovich, Wei Huang, Cecilia Besa, Xin Li, Aneela Afzal, Hadrien A. Dyvorne, Bachir Taouli

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2016

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Abstract

Objective

To quantify hepatocellular carcinoma (HCC) perfusion and flow with the fast exchange regime-allowed Shutter-Speed model (SSM) compared to the Tofts model (TM).

Materials and methods

In this prospective study, 25 patients with HCC underwent DCE-MRI. ROIs were placed in liver parenchyma, portal vein, aorta and HCC lesions. Signal intensities were analyzed employing dual-input TM and SSM models. ART (arterial fraction), K trans (contrast agent transfer rate constant from plasma to extravascular extracellular space), v e (extravascular extracellular volume fraction), k ep (contrast agent intravasation rate constant), and τ i (mean intracellular water molecule lifetime) were compared between liver parenchyma and HCC, and ART, K trans, v e and k ep were compared between models using Wilcoxon tests and limits of agreement. Test–retest reproducibility was assessed in 10 patients.

Results

ART and v e obtained with TM; ART, v e , k e and τ i obtained with SSM were significantly different between liver parenchyma and HCC (p < 0.04). Parameters showed variable reproducibility (CV range 14.7–66.5 % for both models). Liver K trans and v e ; HCC v e and k ep were significantly different when estimated with the two models (p < 0.03).

Conclusion

Our results show differences when computed between the TM and the SSM. However, these differences are smaller than parameter reproducibilities and may be of limited clinical significance.
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Metadata
Title
DCE-MRI of hepatocellular carcinoma: perfusion quantification with Tofts model versus shutter-speed model—initial experience
Authors
Guido H. Jajamovich
Wei Huang
Cecilia Besa
Xin Li
Aneela Afzal
Hadrien A. Dyvorne
Bachir Taouli
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2016
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-015-0513-4

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