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Clinical Autonomic Research
Published in: Clinical Autonomic Research 2/2018

01-04-2018 | Research Article

Autonomic symptoms following Zika virus infection

Authors: Yhojan Rodríguez, Manuel Rojas, Carolina Ramírez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Juan-Manuel Anaya

Published in: Clinical Autonomic Research | Issue 2/2018

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Abstract

Purpose

To determine if autonomic symptoms are associated with previous Zika virus infection.

Methods

Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31).

Results

Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001).

Conclusion

Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.
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Metadata
Title
Autonomic symptoms following Zika virus infection
Authors
Yhojan Rodríguez
Manuel Rojas
Carolina Ramírez-Santana
Yeny Acosta-Ampudia
Diana M. Monsalve
Juan-Manuel Anaya
Publication date
01-04-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 2/2018
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-018-0515-1

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