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01-04-2017 | Editorial

Is pure autonomic failure an early marker for Parkinson disease, dementia with Lewy bodies, and multiple system atrophy? And other updates on recent autonomic research

Authors: Srikanth Muppidi, Mitchell G. Miglis

Published in: Clinical Autonomic Research | Issue 2/2017

Excerpt

Pure autonomic failure (PAF) is a disorder of α-synuclein deposition that results in neurogenic orthostatic hypotension (OH) and other features of autonomic failure, without signs of central nervous system (CNS) involvement. If patients are followed for a sufficient period, some may eventually develop Parkinson disease (PD), multiple system atrophy (MSA), or dementia with Lewy bodies (DLB). Determining which patients will go on to convert to a CNS synucleinopathy and which will remain as PAF has been, so far, a prognostic dilemma for medical providers. Is PAF purely peripheral and restricted to the autonomic nerves, or does it presage a more widespread CNS disorder? …

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Title: Is pure autonomic failure an early marker for Parkinson disease, dementia with Lewy bodies, and multiple system atrophy? And other updates on recent autonomic research
Authors: Srikanth Muppidi
Mitchell G. Miglis
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: Clinical Autonomic Research / Issue 2/2017
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-017-0408-8

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