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Clinical Autonomic Research
Published in: Clinical Autonomic Research 1/2016

Open Access 01-02-2016 | Research Article

Muscle sympathetic nerve activity in frontotemporal lobar degeneration is similar to amyotrophic lateral sclerosis

Authors: Kazumasa Shindo, Michiaki Miwa, Fumikazu Kobayashi, Takamura Nagasaka, Yoshihisa Takiyama

Published in: Clinical Autonomic Research | Issue 1/2016

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Abstract

Purpose

To determine whether frontotemporal lobar degeneration (FTLD) is associated with similar cardiovascular autonomic dysfunction to that seen in amyotrophic lateral sclerosis (ALS), we compared cardiovascular parameters between ALS patients and patients with FTLD.

Methods

In ten patients with FTLD (mean age ± SD: 71.6 ± 4.6 years) and 12 patients with ALS (mean age ± SD: 71.4 ± 4.6 years), MSNA (using microneurography), heart rate (HR), and blood pressure (BP) were recorded simultaneously.

Results

MSNA was significantly higher in both groups of patients compared with the controls (p < 0.01), while there were no significant differences in MSNA between the patients with FTLD and those with ALS. During head-up tilt, changes in HR, BP, and the frequency of MSNA bursts were smaller in the patients than in controls (p < 0.05 or p < 0.01).

Conclusions

Patients with FTLD and ALS showed similar dysfunction of HR, BP, and sympathetic outflow to muscles.
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Metadata
Title
Muscle sympathetic nerve activity in frontotemporal lobar degeneration is similar to amyotrophic lateral sclerosis
Authors
Kazumasa Shindo
Michiaki Miwa
Fumikazu Kobayashi
Takamura Nagasaka
Yoshihisa Takiyama
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 1/2016
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-015-0321-y

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