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Clinical Autonomic Research
Published in: Clinical Autonomic Research 5/2015

01-10-2015 | Short Communication

Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease

Authors: Michaela Kaiserova, Hana Prikrylova Vranova, Jan Galuszka, David Stejskal, Katerina Mensikova, Jana Zapletalova, Jan Mares, Petr Kanovsky

Published in: Clinical Autonomic Research | Issue 5/2015

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Abstract

An association between the CSF chromogranin A (CgA) and orthostatic blood pressure changes was investigated in 20 patients in the early stage of Parkinson disease (PD). There was a positive correlation between the CSF CgA and diastolic blood pressure change, when CSF CgA levels were lower in patients with orthostatic hypotension (OH). Decreased CSF CgA may be useful in predicting OH in the early stage of PD.
Literature
1.
2.
Ha AD, Brown CH, York MK, Jankovic J (2011) The prevalence of symptomatic orthostatic hypotension in patients with Parkinson’s disease and atypical parkinsonism. Parkinsonism Relat Disord 17:625–628CrossRefPubMed
3.
Kato A, Kammen-Jolly K, Fischer-Colbie R, Humpel C, Schrott-Fischer A, Marksteiner J (2000) Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem. Brain Res 852:444–452CrossRefPubMed
4.
Kaiserová M, Vranová HP, Stejskal D, Menšíková K, Kaňovský P (2013) Cerebrospinal fluid levels of chromogranin A in the treatment-naïve early stage Parkinson’s disease: a pilot study. J Neural Transm 120:1559–1563CrossRefPubMed
5.
Gibb WR, Lees AJ (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry 51:745–752PubMedCentralCrossRefPubMed
6.
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 21:69–72CrossRefPubMed
7.
Goldstein DS (2006) Orthostatic hypotension as an early finding in Parkinson’s disease. Clin Auton Res 16:46–54CrossRefPubMed
8.
Goldstein DS, Holmes C, Sharabi Y (2012) Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson’s disease and other synucleinopathies. Brain 135:1900–1913PubMedCentralCrossRefPubMed
9.
Orimo S, Takahashi A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H (2007) Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson’s disease. Brain Pathol 17:24–30CrossRefPubMed
Metadata
Title
Orthostatic hypotension is associated with decreased cerebrospinal fluid levels of chromogranin A in early stage of Parkinson disease
Authors
Michaela Kaiserova
Hana Prikrylova Vranova
Jan Galuszka
David Stejskal
Katerina Mensikova
Jana Zapletalova
Jan Mares
Petr Kanovsky
Publication date
01-10-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 5/2015
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-015-0302-1

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