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Clinical Autonomic Research
Published in: Clinical Autonomic Research 4/2015

01-08-2015 | Case Report

Successful long-term ambulatory norepinephrine infusions in a patient with pure autonomic failure

Authors: A. Zekeridou, P. Michel, F. Medlin, D. Hayoz, P. H. Lalive, T. Kuntzer

Published in: Clinical Autonomic Research | Issue 4/2015

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Abstract

We present a case study of a patient with pure autonomic failure who was successfully treated with ambulatory norepinephrine (NE) infusions over a 9-year-period of time before death occurred unexpectedly. Given this patient’s response to the NE infusion treatment, we discuss the option of ambulatory NE infusions as a treatment for severe orthostatic hypotension that is refractory to common treatments.
Literature
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Benarroch EE (2014) The clinical approach to autonomic failure in neurological disorders. Nat Rev Neurol 10:396–407CrossRefPubMed
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Kaufmann H, Oribe E, Miller M, Knott P, Wiltshire-Clement M, Yahr M (1992) Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Neurology 42:590–593CrossRefPubMed
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Kashihara K, Ohno M, Kawada S, Okumura Y (2006) Reduced cardiac uptake and enhanced washout of 123I-MIBG in pure autonomic failure occurs conjointly with Parkinson’s disease and dementia with Lewy bodies. J Nucl Med 47:1099–1102PubMed
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Oldenburg O, Mitchell A, Nu J, Koeppen S (2001) Ambulatory norepinephrine treatment of severe autonomic orthostatic hypotension. J Am Coll Cardiol 37:219–223CrossRefPubMed
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Kuntzer T, Michel P (2004) Muscle membrane polarisation after provocative tests, and after cooling: the normal CMAP changes to be expected. Clin Neurophysiol 115:1457–1463CrossRefPubMed
Metadata
Title
Successful long-term ambulatory norepinephrine infusions in a patient with pure autonomic failure
Authors
A. Zekeridou
P. Michel
F. Medlin
D. Hayoz
P. H. Lalive
T. Kuntzer
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 4/2015
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-015-0290-1

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