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Clinical Autonomic Research
Published in: Clinical Autonomic Research 1/2015

01-02-2015 | Research Letter

Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla

Authors: E. E. Benarroch, A. M. Schmeichel, J. E. Parisi, P. A. Low

Published in: Clinical Autonomic Research | Issue 1/2015

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Abstract

We used double immunocytochemistry for α-synuclein and markers of sympathoexcitatory neurons, oligodendrocytes, iron metabolism, and autophagy to study putative neuropathological interactions in multiple system atrophy. We focused in the rostral ventrolateral medulla as a prototype vulnerable region. We found that loss of C1 neurons and oligodendrocytes related to glial cytoplasmic inclusion accumulation, downregulation of iron transport, and upregulation of autophagy and ferritin expression in these area.
Literature
1.
Ozawa T, Paviour D, Quinn NP et al (2004) The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations. Brain 127:2657–2671CrossRefPubMed
2.
Armstrong RA, Lantos PL, Cairns NJ (2004) Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy. Mov Disord 19:109–112CrossRefPubMed
3.
Visanji NP, Collingwood JF, Finnegan ME, Tandon A, House E, Hazrati LN (2013) Iron deficiency in parkinsonism: region-specific iron dysregulation in Parkinson’s disease and multiple system atrophy. J Parkinsons Dis 3:523–537PubMed
4.
Schwarz L, Goldbaum O, Bergmann M, Probst-Cousin S, Richter-Landsberg C (2012) Involvement of macroautophagy in multiple system atrophy and protein aggregate formation in oligodendrocytes. J Mol Neurosci 47:256–266CrossRefPubMed
5.
Wenning GK, Stefanova N, Jellinger KA, Poewe W, Schlossmacher MG (2008) Multiple system atrophy: a primary oligodendrogliopathy. Ann Neurol 64:239–246CrossRefPubMed
Metadata
Title
Putative neuropathological interactions in MSA: focus in the rostral ventrolateral medulla
Authors
E. E. Benarroch
A. M. Schmeichel
J. E. Parisi
P. A. Low
Publication date
01-02-2015
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 1/2015
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-015-0273-2

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