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Clinical Autonomic Research
Published in: Clinical Autonomic Research 4/2014

01-08-2014 | Research Article

The effect of oxybutynin on cardiac autonomic modulation in healthy subjects

Authors: Esmaeil Akbari, Amir-Hosein Zare, Abbas Alipour

Published in: Clinical Autonomic Research | Issue 4/2014

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Abstract

Purpose

The aim of this study was to assess the various doses of oral oxybutynin on cardiac autonomic modulation by measuring short-term heart rate variability (HRV) indexes during supine rest position.

Methods

Eight male healthy subjects (20–23 years) participated in the double-blind crossover randomized study. The single dose of oxybutynin (2.5, 5 and 10 mg) or placebo was given to the volunteers in four sessions within 5-day intervals. Before and minutes of 30, 60, 90 and 120 after administration, lead II electrocardiogram (ECG) was recorded for 5 min. ECG extracted RR intervals data became the base of the calculation of time domain and frequency domain HRV parameters, which indicate cardiac autonomic activity. Statistical analysis was done by using the nonparametric Wilcoxon and Kruskal–Wallis tests.

Results

The data analysis has revealed that MNN (P < 0.001), SDNN (P < 0.05), PNN50% (P < 0.01), RMSSD (P < 0.001), HFnu (P < 0.05) and LF/HF ratio (P < 0.05) values were significantly increased relative to baseline at various time points in all the groups except in placebo group. LFnu (P < 0.05) values were significantly increased relative to baseline at various time points in all the groups except in placebo group.

Conclusions

Our findings have revealed that acute consumption of 2.5, 5 and 10 mg oxybutynin (an anticholinergic compound) in the juvenile healthy male subjects produces a cholinergic effect according to time and frequency domain of HRV indexes.
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Metadata
Title
The effect of oxybutynin on cardiac autonomic modulation in healthy subjects
Authors
Esmaeil Akbari
Amir-Hosein Zare
Abbas Alipour
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
Clinical Autonomic Research / Issue 4/2014
Print ISSN: 0959-9851
Electronic ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-014-0247-9

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