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Published in: The European Journal of Health Economics 8/2016

Open Access 01-11-2016 | Original Paper

Direct medical costs attributable to type 2 diabetes mellitus: a population-based study in Catalonia, Spain

Authors: Manel Mata-Cases, Marc Casajuana, Josep Franch-Nadal, Aina Casellas, Conxa Castell, Irene Vinagre, Dídac Mauricio, Bonaventura Bolíbar

Published in: The European Journal of Health Economics | Issue 8/2016

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Abstract

We estimated healthcare costs associated with patients with type 2 diabetes compared with non-diabetic subjects in a population-based primary care database through a retrospective analysis of economic impact during 2011, including 126,811 patients with type 2 diabetes in Catalonia, Spain. Total annual costs included primary care visits, hospitalizations, referrals, diagnostic tests, self-monitoring test strips, medication, and dialysis. For each patient, one control matched for age, gender and managing physician was randomly selected from a population database. The annual average cost per patient was €3110.1 and €1803.6 for diabetic and non-diabetic subjects, respectively (difference €1306.6; i.e., 72.4 % increased cost). The costs of hospitalizations were €1303.1 and €801.6 (62.0 % increase), and medication costs were €925.0 and €489.2 (89.1 % increase) in diabetic and non-diabetic subjects, respectively. In type 2 diabetic patients, hospitalizations and medications had the greatest impact on the overall cost (41.9 and 29.7 %, respectively), generating approximately 70 % of the difference between diabetic and non-diabetic subjects. Patients with poor glycaemic control (glycated haemoglobin >7 %; >53 mmol/mol) had average costs of €3296.5 versus €2848.5 for patients with good control. In the absence of macrovascular complications, average costs were €3008.1 for diabetic and €1612.4 for non-diabetic subjects, while its presence increased costs to €4814.6 and €3306.8, respectively. In conclusion, the estimated higher costs for type 2 diabetes patients compared with non-diabetic subjects are due mainly to hospitalizations and medications, and are higher among diabetic patients with poor glycaemic control and macrovascular complications.
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Literature
1.
go back to reference Ruiz-Ramos, M., Escolar-Pujolar, A., Mayoral-Sanchez, E., Corral-San Laureano, F., Fernandez-Fernandez, I.: Diabetes mellitus in Spain: death rates, prevalence, impact, costs and inequalities. Gac. Sanit. 20(Suppl 1), 15–24 (2006)CrossRefPubMed Ruiz-Ramos, M., Escolar-Pujolar, A., Mayoral-Sanchez, E., Corral-San Laureano, F., Fernandez-Fernandez, I.: Diabetes mellitus in Spain: death rates, prevalence, impact, costs and inequalities. Gac. Sanit. 20(Suppl 1), 15–24 (2006)CrossRefPubMed
2.
go back to reference Gonzalez, P., Faure, E., Del Castillo, A.: Cost of diabetes mellitus in Spain. Med. Clin. (Barc.) 127(20), 776–784 (2006)CrossRef Gonzalez, P., Faure, E., Del Castillo, A.: Cost of diabetes mellitus in Spain. Med. Clin. (Barc.) 127(20), 776–784 (2006)CrossRef
3.
go back to reference Ballesta, M., Carral, F., Olveira, G., Giron, J.A., Aguilar, M.: Economic cost associated with type II diabetes in Spanish patients. Eur. J. Health Econ. 7(4), 270–275 (2006)CrossRefPubMed Ballesta, M., Carral, F., Olveira, G., Giron, J.A., Aguilar, M.: Economic cost associated with type II diabetes in Spanish patients. Eur. J. Health Econ. 7(4), 270–275 (2006)CrossRefPubMed
4.
go back to reference Soriguer, F., Goday, A., Bosch-Comas, A., Bordiu, E., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castano, L., Castell, C., Catala, M., Delgado, E., Franch, J., Gaztambide, S., Girbes, J., Gomis, R., Gutierrez, G., Lopez-Alba, A., Martinez-Larrad, M.T., Menendez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Rojo-Martinez, G., Serrano-Rios, M., Valdes, S., Vazquez, J.A., Vendrell, J.: Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia 55(1), 88–93 (2012)CrossRefPubMed Soriguer, F., Goday, A., Bosch-Comas, A., Bordiu, E., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castano, L., Castell, C., Catala, M., Delgado, E., Franch, J., Gaztambide, S., Girbes, J., Gomis, R., Gutierrez, G., Lopez-Alba, A., Martinez-Larrad, M.T., Menendez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Rojo-Martinez, G., Serrano-Rios, M., Valdes, S., Vazquez, J.A., Vendrell, J.: Prevalence of diabetes mellitus and impaired glucose regulation in Spain: the Di@bet.es Study. Diabetologia 55(1), 88–93 (2012)CrossRefPubMed
5.
6.
go back to reference Lopez Bastida, J., Serrano Aguilar, P., Duque Gonzalez, B.: The social and economic cost of diabetes mellitus. Aten. Prim. 29(3), 145–150 (2002)CrossRef Lopez Bastida, J., Serrano Aguilar, P., Duque Gonzalez, B.: The social and economic cost of diabetes mellitus. Aten. Prim. 29(3), 145–150 (2002)CrossRef
7.
go back to reference Carral, F., Olveira, G., Salas, J., Garcia, L., Sillero, A., Aguilar, M.: Care resource utilization and direct costs incurred by people with diabetes in a Spanish hospital. Diabetes Res. Clin. Pract. 56(1), 27–34 (2002)CrossRefPubMed Carral, F., Olveira, G., Salas, J., Garcia, L., Sillero, A., Aguilar, M.: Care resource utilization and direct costs incurred by people with diabetes in a Spanish hospital. Diabetes Res. Clin. Pract. 56(1), 27–34 (2002)CrossRefPubMed
8.
go back to reference Alcubierre, N., Rubinat, E., Traveset, A., Martinez-Alonso, M., Hernandez, M., Jurjo, C., Mauricio, D.: A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications. Health Qual. Life Outcomes 12, 131 (2014)CrossRefPubMedPubMedCentral Alcubierre, N., Rubinat, E., Traveset, A., Martinez-Alonso, M., Hernandez, M., Jurjo, C., Mauricio, D.: A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications. Health Qual. Life Outcomes 12, 131 (2014)CrossRefPubMedPubMedCentral
9.
go back to reference Rubin, R.J., Altman, W.M., Mendelson, D.N.: Health care expenditures for people with diabetes mellitus, 1992. J. Clin. Endocrinol. Metab. 78(4), 809A–809F (1994)CrossRefPubMed Rubin, R.J., Altman, W.M., Mendelson, D.N.: Health care expenditures for people with diabetes mellitus, 1992. J. Clin. Endocrinol. Metab. 78(4), 809A–809F (1994)CrossRefPubMed
10.
go back to reference Brito-Sanfiel, M., Diago-Cabezudo, J., Calderon, A.: Economic impact of hypoglycemia on healthcare in Spain. Expert Rev. Pharmacoecon. Outcomes Res. 10(6), 649–660 (2010)CrossRefPubMed Brito-Sanfiel, M., Diago-Cabezudo, J., Calderon, A.: Economic impact of hypoglycemia on healthcare in Spain. Expert Rev. Pharmacoecon. Outcomes Res. 10(6), 649–660 (2010)CrossRefPubMed
11.
go back to reference Ariza, M.A., Vimalananda, V.G., Rosenzweig, J.L.: The economic consequences of diabetes and cardiovascular disease in the United States. Rev. Endocr. Metab. Disord. 11(1), 1–10 (2010)CrossRefPubMed Ariza, M.A., Vimalananda, V.G., Rosenzweig, J.L.: The economic consequences of diabetes and cardiovascular disease in the United States. Rev. Endocr. Metab. Disord. 11(1), 1–10 (2010)CrossRefPubMed
12.
go back to reference Li, R., Bilik, D., Brown, M.B., Zhang, P., Ettner, S.L., Ackermann, R.T., Crosson, J.C., Herman, W.H.: Medical costs associated with type 2 diabetes complications and comorbidities. Am. J. Manag. Care 19(5), 421–430 (2013)PubMedPubMedCentral Li, R., Bilik, D., Brown, M.B., Zhang, P., Ettner, S.L., Ackermann, R.T., Crosson, J.C., Herman, W.H.: Medical costs associated with type 2 diabetes complications and comorbidities. Am. J. Manag. Care 19(5), 421–430 (2013)PubMedPubMedCentral
13.
go back to reference Wirehn, A.B., Andersson, A., Ostgren, C.J., Carstensen, J.: Age-specific direct healthcare costs attributable to diabetes in a Swedish population: a register-based analysis. Diabet. Med. 25(6), 732–737 (2008)CrossRefPubMed Wirehn, A.B., Andersson, A., Ostgren, C.J., Carstensen, J.: Age-specific direct healthcare costs attributable to diabetes in a Swedish population: a register-based analysis. Diabet. Med. 25(6), 732–737 (2008)CrossRefPubMed
14.
go back to reference Bruno, G., Picariello, R., Petrelli, A., Panero, F., Costa, G., Cavallo-Perin, P., Demaria, M., Gnavi, R.: Direct costs in diabetic and non diabetic people: the population-based Turin study, Italy. Nutr. Metab. Cardiovasc. Dis. 22(8), 684–690 (2012)CrossRefPubMed Bruno, G., Picariello, R., Petrelli, A., Panero, F., Costa, G., Cavallo-Perin, P., Demaria, M., Gnavi, R.: Direct costs in diabetic and non diabetic people: the population-based Turin study, Italy. Nutr. Metab. Cardiovasc. Dis. 22(8), 684–690 (2012)CrossRefPubMed
15.
go back to reference Mata, M., Antonanzas, F., Tafalla, M., Sanz, P.: The cost of type 2 diabetes in Spain: the CODE-2 study. Gac. Sanit. 16(6), 511–520 (2002)CrossRefPubMed Mata, M., Antonanzas, F., Tafalla, M., Sanz, P.: The cost of type 2 diabetes in Spain: the CODE-2 study. Gac. Sanit. 16(6), 511–520 (2002)CrossRefPubMed
16.
go back to reference Koster, I., Huppertz, E., Hauner, H., Schubert, I.: Costs of Diabetes Mellitus (CoDiM) in Germany, direct per-capita costs of managing hyperglycaemia and diabetes complications in 2010 compared to 2001. Exp. Clin. Endocrinol. Diabetes 122(9), 510–516 (2014)CrossRefPubMed Koster, I., Huppertz, E., Hauner, H., Schubert, I.: Costs of Diabetes Mellitus (CoDiM) in Germany, direct per-capita costs of managing hyperglycaemia and diabetes complications in 2010 compared to 2001. Exp. Clin. Endocrinol. Diabetes 122(9), 510–516 (2014)CrossRefPubMed
17.
go back to reference Koster, I., von Ferber, L., Ihle, P., Schubert, I., Hauner, H.: The cost burden of diabetes mellitus: the evidence from Germany—the CoDiM study. Diabetologia 49(7), 1498–1504 (2006)CrossRefPubMed Koster, I., von Ferber, L., Ihle, P., Schubert, I., Hauner, H.: The cost burden of diabetes mellitus: the evidence from Germany—the CoDiM study. Diabetologia 49(7), 1498–1504 (2006)CrossRefPubMed
18.
go back to reference American Diabetes Association: Economic costs of diabetes in the U.S. in 2007. Diabetes Care 31(3), 596–615 (2008)CrossRef American Diabetes Association: Economic costs of diabetes in the U.S. in 2007. Diabetes Care 31(3), 596–615 (2008)CrossRef
19.
go back to reference Sicras-Mainar, A., Navarro-Artieda, R., Ibanez-Nolla, J.: Clinical and economic characteristics associated with type 2 diabetes. Rev. Clin. Esp. 214(3), 121–130 (2014)CrossRefPubMed Sicras-Mainar, A., Navarro-Artieda, R., Ibanez-Nolla, J.: Clinical and economic characteristics associated with type 2 diabetes. Rev. Clin. Esp. 214(3), 121–130 (2014)CrossRefPubMed
20.
go back to reference Vinagre, I., Mata-Cases, M., Hermosilla, E., Morros, R., Fina, F., Rosell, M., Castell, C., Franch-Nadal, J., Bolibar, B., Mauricio, D.: Control of glycemia and cardiovascular risk factors in patients with type 2 diabetes in primary care in Catalonia (Spain). Diabetes Care 35(4), 774–779 (2012)CrossRefPubMedPubMedCentral Vinagre, I., Mata-Cases, M., Hermosilla, E., Morros, R., Fina, F., Rosell, M., Castell, C., Franch-Nadal, J., Bolibar, B., Mauricio, D.: Control of glycemia and cardiovascular risk factors in patients with type 2 diabetes in primary care in Catalonia (Spain). Diabetes Care 35(4), 774–779 (2012)CrossRefPubMedPubMedCentral
21.
go back to reference Mata-Cases, M., Roura-Olmeda, P., Berengue-Iglesias, M., Birules-Pons, M., Mundet-Tuduri, X., Franch-Nadal, J., Benito-Badorrey, B., Cano-Perez, J.F.: Fifteen years of continuous improvement of quality care of type 2 diabetes mellitus in primary care in Catalonia, Spain. Int. J. Clin. Pract. 66(3), 289–298 (2012)CrossRefPubMedPubMedCentral Mata-Cases, M., Roura-Olmeda, P., Berengue-Iglesias, M., Birules-Pons, M., Mundet-Tuduri, X., Franch-Nadal, J., Benito-Badorrey, B., Cano-Perez, J.F.: Fifteen years of continuous improvement of quality care of type 2 diabetes mellitus in primary care in Catalonia, Spain. Int. J. Clin. Pract. 66(3), 289–298 (2012)CrossRefPubMedPubMedCentral
22.
go back to reference Franch-Nadal, J., Mata-Cases, M., Vinagre, I., Patitucci, F., Hermosilla, E., Casellas, A., Bolivar, B., Mauricio, D.: Differences in the cardiometabolic control in type 2 diabetes according to gender and the presence of cardiovascular disease: results from the eControl study. Int. J. Endocrinol. 2014, 131709 (2014)CrossRefPubMedPubMedCentral Franch-Nadal, J., Mata-Cases, M., Vinagre, I., Patitucci, F., Hermosilla, E., Casellas, A., Bolivar, B., Mauricio, D.: Differences in the cardiometabolic control in type 2 diabetes according to gender and the presence of cardiovascular disease: results from the eControl study. Int. J. Endocrinol. 2014, 131709 (2014)CrossRefPubMedPubMedCentral
23.
go back to reference Bolibar, B., Fina, A.F., Morros, R., Garcia-Gil, M.M., Hermosilla, E., Ramos, R., Rosell, M., Rodriguez, J., Medina, M., Calero, S., Prieto-Alhambra, D., Grupo SIDIAP: SIDIAP database: electronic clinical records in primary care as a source of information for epidemiologic research. Med. Clin. (Barc.) 138(14), 617–621 (2012)CrossRef Bolibar, B., Fina, A.F., Morros, R., Garcia-Gil, M.M., Hermosilla, E., Ramos, R., Rosell, M., Rodriguez, J., Medina, M., Calero, S., Prieto-Alhambra, D., Grupo SIDIAP: SIDIAP database: electronic clinical records in primary care as a source of information for epidemiologic research. Med. Clin. (Barc.) 138(14), 617–621 (2012)CrossRef
24.
go back to reference Garcia-Gil Mdel, M., Hermosilla, E., Prieto-Alhambra, D., Fina, F., Rosell, M., Ramos, R., Rodriguez, J., Williams, T., Van Staa, T., Bolibar, B.: Construction and validation of a scoring system for the selection of high-quality data in a Spanish population primary care database (SIDIAP). Inform. Prim. Care 19(3), 135–145 (2011)PubMed Garcia-Gil Mdel, M., Hermosilla, E., Prieto-Alhambra, D., Fina, F., Rosell, M., Ramos, R., Rodriguez, J., Williams, T., Van Staa, T., Bolibar, B.: Construction and validation of a scoring system for the selection of high-quality data in a Spanish population primary care database (SIDIAP). Inform. Prim. Care 19(3), 135–145 (2011)PubMed
25.
go back to reference Generalitat de Catalunya. Servei Català de la Salut. Registre del conjunt mínim bàsic de dades dels hospitals d’aguts (CMBD-HA). Especificacions de la validació de les dades (Àmbit AH). Available from http://www20.gencat.cat/. Accessed 31 May 2010 Generalitat de Catalunya. Servei Català de la Salut. Registre del conjunt mínim bàsic de dades dels hospitals d’aguts (CMBD-HA). Especificacions de la validació de les dades (Àmbit AH). Available from http://​www20.​gencat.​cat/​. Accessed 31 May 2010
28.
go back to reference Fetter, R.B., Shin, Y., Freeman, J.L., Averill, R.F., Thompson, J.D.: Case mix definition by diagnosis-related groups. Med. Care 18(2 Suppl)iii, 1–53 (1980) Fetter, R.B., Shin, Y., Freeman, J.L., Averill, R.F., Thompson, J.D.: Case mix definition by diagnosis-related groups. Med. Care 18(2 Suppl)iii, 1–53 (1980)
32.
go back to reference Dodd, S., Bassi, A., Bodger, K., Williamson, P.: A comparison of multivariable regression models to analyse cost data. J. Eval. Clin. Pract. 12(1), 76–86 (2006)CrossRefPubMed Dodd, S., Bassi, A., Bodger, K., Williamson, P.: A comparison of multivariable regression models to analyse cost data. J. Eval. Clin. Pract. 12(1), 76–86 (2006)CrossRefPubMed
33.
go back to reference Jackman, S.: pscl: classes and methods for R developed in the political science computational laboratory, Stanford University. Department of Political Science, Stanford University. Stanford, California. R package version 1.4.9. http://pscl.stanford.edu/ (2015) Jackman, S.: pscl: classes and methods for R developed in the political science computational laboratory, Stanford University. Department of Political Science, Stanford University. Stanford, California. R package version 1.4.9. http://​pscl.​stanford.​edu/​ (2015)
34.
go back to reference Crespo, C., Brosa, M., Soria-Juan, A., López-Alba, A., Lopez-Martínez, N., Soria, B.: Direct cost of diabetes mellitus and its complications in Spain (SECCAID Study: Spain estimated cost Ciberdem-Cabimer in Diabetes). Diabetologia 29(6), 182–189 (2013) Crespo, C., Brosa, M., Soria-Juan, A., López-Alba, A., Lopez-Martínez, N., Soria, B.: Direct cost of diabetes mellitus and its complications in Spain (SECCAID Study: Spain estimated cost Ciberdem-Cabimer in Diabetes). Diabetologia 29(6), 182–189 (2013)
35.
go back to reference Yi, Y., Philips, Z., Bergman, G., Burslem, K.: Economic models in type 2 diabetes. Curr. Med. Res. Opin. 26(9), 2105–2118 (2010)CrossRefPubMed Yi, Y., Philips, Z., Bergman, G., Burslem, K.: Economic models in type 2 diabetes. Curr. Med. Res. Opin. 26(9), 2105–2118 (2010)CrossRefPubMed
36.
go back to reference Inoriza, J.M., Perez, M., Cols, M., Sanchez, I., Carreras, M., Coderch, J.: An analysis of the diabetic population in a Spanish rural are: morbidity profile, use of resources, complications and metabolic control. Aten. Prim. 45(9), 461–475 (2013)CrossRef Inoriza, J.M., Perez, M., Cols, M., Sanchez, I., Carreras, M., Coderch, J.: An analysis of the diabetic population in a Spanish rural are: morbidity profile, use of resources, complications and metabolic control. Aten. Prim. 45(9), 461–475 (2013)CrossRef
37.
38.
go back to reference Gene, B.J.: The gatekeeper role of the general practitioner and the reform of the National Health Service as seen from Barcelona, Spain. Gac. Sanit. 13(5), 410–412 (1999)CrossRef Gene, B.J.: The gatekeeper role of the general practitioner and the reform of the National Health Service as seen from Barcelona, Spain. Gac. Sanit. 13(5), 410–412 (1999)CrossRef
Metadata
Title
Direct medical costs attributable to type 2 diabetes mellitus: a population-based study in Catalonia, Spain
Authors
Manel Mata-Cases
Marc Casajuana
Josep Franch-Nadal
Aina Casellas
Conxa Castell
Irene Vinagre
Dídac Mauricio
Bonaventura Bolíbar
Publication date
01-11-2016
Publisher
Springer Berlin Heidelberg
Published in
The European Journal of Health Economics / Issue 8/2016
Print ISSN: 1618-7598
Electronic ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-015-0742-5

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