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The European Journal of Health Economics
Published in: The European Journal of Health Economics 2/2012

01-04-2012 | Original Paper

Cost-effectiveness of treatment with etanercept for psoriasis in Sweden

Authors: Christopher Knight, Josephine Mauskopf, Mats Ekelund, Amitabh Singh, Shiyi Yang, Robert Boggs

Published in: The European Journal of Health Economics | Issue 2/2012

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Abstract

Objective

To estimate the cost-effectiveness, from a Swedish societal perspective, of intermittent use of etanercept (Enbrel) with interruptions of use after 24 weeks compared to continuous use of adalimumab (Humira) as well as non-systemic standard of care in patients with moderate to severe psoriasis.

Methods

A Markov decision-tree model was constructed from clinical trials results. Patients starting etanercept, adalimumab, or non-systemic therapy moved through the model’s 10-years horizon. Model input parameters included clinical response rates. Outcome measures included direct and indirect costs and quality-adjusted life-years (QALYs).

Results

The incremental total (direct and indirect) costs per QALY were 1,559,939 kr (€165,354) for adalimumab 40 mg every other week, compared with intermittent once-weekly Enbrel 50 mg, and 93,629 kr (€9,925) for once-weekly intermittent etanercept 50 mg compared with non-systemic standard of care.

Conclusions

This analysis showed that, with a 470,000 kr (€50,000) per QALY willingness-to-pay threshold, once-weekly etanercept 50 mg, used intermittently, is a cost-effective treatment for moderate to severe psoriasis compared with adalimumab and non-systemic standard of care.
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Metadata
Title
Cost-effectiveness of treatment with etanercept for psoriasis in Sweden
Authors
Christopher Knight
Josephine Mauskopf
Mats Ekelund
Amitabh Singh
Shiyi Yang
Robert Boggs
Publication date
01-04-2012
Publisher
Springer-Verlag
Published in
The European Journal of Health Economics / Issue 2/2012
Print ISSN: 1618-7598
Electronic ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-010-0293-8

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