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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 3/2011

Open Access 01-06-2011 | Original

Does visual cortex lactate increase following photic stimulation in migraine without aura patients? A functional 1H-MRS study

Authors: Harmen Reyngoudt, Koen Paemeleire, Anneloor Dierickx, Benedicte Descamps, Pieter Vandemaele, Yves De Deene, Eric Achten

Published in: The Journal of Headache and Pain | Issue 3/2011

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Abstract

Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to assess noninvasively the temporal changes of lactate (Lac) in the activated human brain. Migraine neurobiology involves lack of cortical habituation to repetitive stimuli and a mitochondrial component has been put forward. Our group has recently demonstrated a reduction in the high-energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr) in the occipital lobe of migraine without aura (MwoA) patients, at least in a subgroup, in a phosphorus MRS (31P-MRS) study. In previous studies, basal Lac levels or photic stimulation (PS)-induced Lac levels were found to be increased in patients with migraine with aura (MwA) and migraine patients with visual symptoms and paraesthesia, paresia and/or dysphasia, respectively. The aim of this study was to perform functional 1H-MRS at 3 T in 20 MwoA patients and 20 control subjects. Repetitive visual stimulation was applied using MR-compatible goggles with 8 Hz checkerboard stimulation during 12 min. We did not observe any significant differences in signal integrals, ratios and absolute metabolite concentrations, including Lac, between MwoA patients and controls before PS. Lac also did not increase significantly during and following PS, both for MwoA patients and controls. Subtle Lac changes, smaller than the sensitivity threshold (i.e. estimated at 0.1–0.2 μmol/g at 3 T), cannot be detected by MRS. Our study does, however, argue against a significant switch to non-aerobic glucose metabolism during long-lasting PS of the visual cortex in MwoA patients.
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Metadata
Title
Does visual cortex lactate increase following photic stimulation in migraine without aura patients? A functional 1H-MRS study
Authors
Harmen Reyngoudt
Koen Paemeleire
Anneloor Dierickx
Benedicte Descamps
Pieter Vandemaele
Yves De Deene
Eric Achten
Publication date
01-06-2011
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 3/2011
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1007/s10194-011-0295-7

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