Top

Published in:

Open Access 01-06-2009 | Brief Report

Psychiatric disorders and headache familial recurrence: a study on 200 children and their parents

Authors: Federica Galli, Loredana Canzano, Teresa Gloria Scalisi, Vincenzo Guidetti

Published in: The Journal of Headache and Pain | Issue 3/2009

Abstract

The main aim of the study was to examine the relationship between headache and familial recurrence of psychiatric disorders in parents and their children. Headache history and symptomatology have been collected in a clinical sample of 200 patients and their families, using a semi-structured interview (ICHD-II criteria). Psychiatric comorbidity was assessed by DSM-IV criteria. Chi squares and a loglinear analysis were computed in order to evaluate the main effects and interactions between the following factors: frequency and headache subtypes (migraine/not-migraine) in children, headache (migraine/not-migraine-absent/present) in parents, headache (absent/present) in grandparents, and psychiatric comorbidity (absent/present) have been analyzed: 94 mothers (47%) and 51 fathers (25.5%) had at least one psychiatric disorder, mainly mood and anxiety disorders. Considering the significant prevalence of Psi-co in children (P < 0.0001), we compared it with the presence of familiarity to headache: a significant interaction has been found (P < 0.05) showing that migraineurs with high familial recurrence of headache had a higher percentage (74.65%) of psychiatric disorders, than no-migraineurs (52.17%). Absence of headache familial loading seems to be related to psi-co only in no-migraine headache (87.5 vs. 45.5%). The occurrence of psychiatric disorders is high in children with headache, but a very different pattern seems to characterize migraine (familial co-transmission of migraine and Psi-Co?) if compared with non-migraine headache.

Montagna P (2000) Molecular genetics of migraine headaches: a review. Cephalalgia 20:3–14, 10817441, 10.1046/j.1468-2982.2000.00003.x, 1:STN:280:DC%2BD3c3nsFWnsA%3D%3DPubMedCrossRef

Kors EE, Vanmolkot KRJ, Haan J, Frants RR, Van den Maagdenberg AMJM, Ferrari M (2004) Recent findings in headache genetics. Curr Opin Neurol 17(3):283–288, 15167062, 10.1097/00019052-200406000-00008PubMedCrossRef

Wessman M, Terwindt GM, Kaunisto MA, Palotie A, Ophoff RA (2007) Migraine: a complex genetic disorder. Lancet Neurol 6:521–532, 17509487, 10.1016/S1474-4422(07)70126-6, 1:CAS:528:DC%2BD2sXmslKktrw%3DPubMedCrossRef

Colson NJ, Fernandez F, Lea RA, Griffiths LR (2007) The search for migraine genes: an overview of current knowledge. Cell Mol Life Sci 64:331–344, 17187176, 10.1007/s00018-006-5592-y, 1:CAS:528:DC%2BD2sXjtlSrs78%3DPubMedCrossRef

Van de Ven RC, Kaja S, Plomp JJ et al (2007) Genetic models of migraine. Arch Neurol 64:643–646, 17502463, 10.1001/archneur.64.5.643PubMedCrossRef

Van de Maagdenberg AM, Haan J, Terwindt GM, Ferrari MD (2007) Migraine: gene mutations and functional consequences. Curr Opin Neurol 20:299–305, 17495624, 10.1097/WCO.0b013e3281338d1fPubMedCrossRef

Russell MB (2007) Genetics in primary headaches. J Headache Pain 8:190–195, 17563838, 10.1007/s10194-007-0389-4PubMedCentralPubMedCrossRef

Russell MB (1997) Genetic epidemiology of migraine and cluster headache. Cephalalgia 17:683–701, 9350392, 10.1046/j.1468-2982.1997.1706683.x, 1:STN:280:DyaK1c%2FhtFCktA%3D%3DPubMedCrossRef

Ferrari MD (1998) Migraine. Lancet 351:1043–1051, 9546526, 10.1016/S0140-6736(97)11370-8, 1:STN:280:DyaK1c3gs1KjsA%3D%3DPubMedCrossRef

10.

Vahlquist B (1955) Migraine in children. Int Arch Allergy 7:348–355, 13306348, 1:STN:280:DyaG28%2FlvVOjsg%3D%3DPubMedCrossRef

11.

Congdon PJ, Forsythe WI (1979) Migraine in childhood: a study of 300 children. Dev Med Child Neurol 21:209–216, 10.1111/j.1469-8749.1979.tb01603.xCrossRef

12.

Prensky AL, Sommer D (1979) Diagnosis and treatment of migraine in children. Neurology 21:506–510CrossRef

13.

Elser JM, Woody RC (1990) Migraine headache in the infant and young child. Headache 30:366–368, 2370139, 10.1111/j.1526-4610.1990.hed3006366.x, 1:STN:280:DyaK3czhs1Omuw%3D%3DPubMedCrossRef

14.

Messinger HB, Spierings EL, Vincent AJ, Lebbink J (1991) Headache and family history. Cephalalgia 11:13–18, 2036664, 10.1046/j.1468-2982.1991.1101013.x, 1:STN:280:DyaK3M3ktlWlug%3D%3DPubMedCrossRef

15.

Russell MB, Olesen J (1995) Increased familial risk and evidence of a genetic factor in migraine. Br Med J 311:541–544, 1:STN:280:DyaK2Mzpt1amsw%3D%3DCrossRef

16.

Ducros A, Tournier-Lasserve E, Bousser MG (2002) The genetics of migraine. Lancet Neurol 1:285–293, 12849426, 10.1016/S1474-4422(02)00134-5, 1:CAS:528:DC%2BD3sXkvFOgsLk%3DPubMedCrossRef

17.

Mulder EJ, Van Baal Gaist D et al (2003) Genetic and environmental influences on migraine: a twin study across six countries. Twin Res 6(5):422–431, 14624726, 10.1375/136905203770326420PubMedCrossRef

18.

Larsson B, Bille B, Pedersen NL (1995) Genetic influences in headache: a Swedish twin study. Headache 35:513–519, 8530274, 10.1111/j.1526-4610.1995.hed3509513.x, 1:STN:280:DyaK28%2FosVCrsg%3D%3DPubMedCrossRef

19.

Ziegler DK, Hur YM, Bouchard TJ Jr, Hassanein RS, Barter R (1998) Migraine in twins raised together and apart. Headache 38:417–422, 9664744, 10.1046/j.1526-4610.1998.3806417.x, 1:STN:280:DyaK1czivFCntA%3D%3DPubMedCrossRef

20.

Gervil M, Ulrich V, Kaprio J, Olesen J, Russell MB (1999) The relative role of genetic and environmental factors in migraine without aura. Neurology 53:995–999, 10496258, 1:STN:280:DyaK1MvisVGktQ%3D%3DPubMedCrossRef

21.

Cao M, Zhang S, Wang Y, Wang W (2002) Personality traits in migraine and tension-type headache:a five factor model study. Psychopathology 35:254–258, 12239443, 10.1159/000063829PubMedCrossRef

22.

Bensenor IM, Tofoli LF, Andrade L (2003) Headache complaints associated with psychiatric comorbidity in a population-based sample. Braz J Med Biol Res 36:1425–1432, 14502377, 10.1590/S0100-879X2003001000021, 1:STN:280:DC%2BD3svjvFOltw%3D%3DPubMedCrossRef

23.

Zwart JA, Dyb G, Hagen K, Odegard KJ, Dahl AA, Bovim G, Stovner LJ (2003) Depression and anxiety disorders associated with headache frequency The Nord-Trondelag Health Study. Eur J Neurol 10:147–152, 12603289, 10.1046/j.1468-1331.2003.00551.xPubMedCrossRef

24.

Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders (2004) Cephalalgia 24(1):1–160

25.

Russell MB, Fenger K, Olesen J (1996) Family history of headache disorders: direct versus indirect information. Cephalalgia 16:156–160, 8734766, 10.1046/j.1468-2982.1996.1603156.x, 1:STN:280:DyaK28zhslSgug%3D%3DPubMedCrossRef

26.

Tabachnick BG, Fidell LS (2006) Using multivariate statistics. Allyn & Bacon Inc., Needham Heights

27.

Østergaard S, Russell MB, Bendsten L, Olesen J (1997) Comparison of first-degree relatives and spouses of people with chronic tension-type headache. BMJ 3(14):1092–1093CrossRef

28.

Russell MB (2000) Complex segregation analysis in headache disorders. In: Genetic of headache disorders. In: Olesen J, Bousser MG (eds) Lippincott Williams & Wilkins, Philadelphia, pp 75–82

29.

Merikangas KR, Merikangas JR, Angst J (1993) Headache syndromes and psychiatric disorders: association and familial transmission. J Psychiatr Res 27:197–210, 8366469, 10.1016/0022-3956(93)90008-P, 1:STN:280:DyaK3sznsFClsA%3D%3DPubMedCrossRef

30.

Guidetti V, Galli F, Fabrizi P, Napoli L, Giannantoni AS, Bruni O, Trillo S (1998) Headache and psychiatric comorbidity: clinical aspects and outcome in an 8-year follow-up study. Cephalalgia 7(18):455–462

31.

Karwautz A, Wöber C, Lang T et al (1999) Psychosocial factors in children and adolescents with migraine and tension-type headache: a controlled study and review of the literature. Cephalalgia 19:32–43, 10099858, 10.1046/j.1468-2982.1999.1901032.x, 1:STN:280:DyaK1M7pvFKgsw%3D%3DPubMedCrossRef

32.

Galli F, D’Antuono G, Tarantino S, Viviano F, Borrelli O, Chirumbolo A, Cucchiara S, Guidetti V (2007) Headache and recurrent abdominal pain: a controlled study by the means of the Child Behaviour Checklist (CBCL). Cephalalgia 27(3):211–219, 17381555, 10.1111/j.1468-2982.2006.01271.x, 1:STN:280:DC%2BD2s7otFKgsw%3D%3DPubMedCrossRef

33.

Williams LJ, Jacka FN, Pasco JA et al (2006) Depression and pain: an overview. Acta Neuropsychiatrica 18(2):79–87,10.1111/j.1601-5215.2006.00130.xCrossRef

34.

Arnstein P, Caudill M, Mandle CL et al (2004) Self efficacy as a mediator of the relationship between pain intensity, disability and depression in chronic pain patients. Pain 80(3):483–491, 10.1016/S0304-3959(98)00220-6CrossRef

35.

Verma S, Gallagher RM (2001) The psychopharmocologic treatment of depression and anxiety in the context of chronic pain. Curr Pain Headache Rep 6(1):30–39, 10.1007/s11916-002-0021-xCrossRef

36.

Gallagher RM, Verma S (1999) Managing pain and comorbid depression: a public health challenge. Sem Clin Neuropsychiatry 4(3):203–220, 1:STN:280:DyaK1Mvjt1Chuw%3D%3D

37.

Blackburn-Munro G, Blackburn-Munro RE (2001) Chronic pain, chronic stress and depression: coincidence or consequence. J Neuroendocrinol 13(12):1009–1023, 11722697, 10.1046/j.0007-1331.2001.00727.x, 1:CAS:528:DC%2BD3MXovFOjurY%3DPubMedCrossRef

38.

Gonda X, Rihmer Z, Juhasz G, Zsombok T, Bagdy G (2007) High anxiety and migraine are associated to s allele of the 5HTTLPR gene polymorphism. Psychiatr Res 149:261–266, 10.1016/j.psychres.2006.05.014, 1:CAS:528:DC%2BD2sXnslGltA%3D%3DCrossRef

39.

Montagna P, Cevoli S, Marzocchi N et al (2003) The genetics of chronic headaches. Neurol Sci 24(Suppl 2):S51–S56, 12811592PubMed

40.

Caldecott-Hazard S, Morgan DG, De Leon-Jones F, Overstreet DH, Janowsky D (1991) Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories. Synapse 9:251–301, 1685032, 10.1002/syn.890090404, 1:CAS:528:DyaK38Xht1GktL4%3DPubMedCrossRef

41.

Peroutka SJ, Price SC, Wilhoit TL, Jones KW (1998) Comorbid migraine with aura, anxiety, and depression is associated with dopamine D2 receptor (DRD2) NcoI alleles. Mol Med 4:14–21, 9513185, 1:STN:280:DyaK1c7nsVeksg%3D%3DPubMedCentralPubMed

42.

Jarman J, Fernandez M, Davies PT et al (1990) High incidence of endogenous depression in migraine: confirmation by tyramine test. J Neurol Neurosurg Psychiatry 53:573–575, 2391520, 10.1136/jnnp.53.7.573, 1:STN:280:DyaK3czmt1WisQ%3D%3DPubMedCentralPubMedCrossRef

43.

Molgat CV, Patten SB (2005) Comorbidity of major depression and migraine—a Canadian population-based study. Can J Psychiatry 50:832–837, 16483117PubMed

44.

Breslau N, Schultz LR, Stewart WF et al (2000) Headache and major depression: is the association specific to migraine? Neurology 54:308–313, 10668688, 1:STN:280:DC%2BD3c7jt1WhsA%3D%3DPubMedCrossRef

45.

Oedegaard KJ, Angst J, Neckelmann D et al (2005) Migraine aura without headache compared to migraine with aura in patients with affective disorders. J Headache Pain 6:378–386, 16362710, 10.1007/s10194-005-0236-4PubMedCentralPubMedCrossRef

46.

Smitherman TA, Maizels M, Penzien DB (2008) Headache chronification: screening and behavioral management of comorbid depressive and anxiety disorders. Headache 48:45–50, 18184285PubMedCrossRef

47.

Mattsson P, Ekselius L (2002) Migraine, major depression, panic disorder, and personality traits in women aged 40–74 years: a population-based study. Cephalalgia 22:543–551, 12230596, 10.1046/j.1468-2982.2002.00407.x, 1:STN:280:DC%2BD38vntVGqtQ%3D%3DPubMedCrossRef

48.

Merikangas KR, Risch NJ, Merikangas JR et al (1988) Migraine and depression: association and familial transmission. J Psychiatr Res 22:119–129, 3404480, 10.1016/0022-3956(88)90076-3, 1:STN:280:DyaL1czgtVKruw%3D%3DPubMedCrossRef

49.

Silberstein SD, Lipton RB, Breslau N (1995) Migraine: association with personality characteristics and psychopathology. Cephalalgia 15:337–369, 10.1046/j.1468-2982.1995.1505358.xCrossRef

50.

Hung CI, Wang SJ, Hsu KH (2005) Risk factors associated with migraine or chronic daily headache in out-patients with major depressive disorder. Acta Psychiatr Scand 111:310–315, 15740467, 10.1111/j.1600-0447.2004.00431.xPubMedCrossRef

51.

Mongini F, Rota E, Deregibus A et al (2006) Accompanying symptoms and psychiatric comorbidity in migraine and tension-type headache patients. J Psychosom Res 61:447–451, 17011351, 10.1016/j.jpsychores.2006.03.005PubMedCrossRef

52.

Beghi E, Allais G, Cortelli D et al (2007) Headache and anxiety-depressive disorder comorbidity: the HADAS study. Neurol Sci 28:S217–S219, 17508174, 10.1007/s10072-007-0780-6PubMedCrossRef

53.

Torelli P, Lambru G, Manzoni GC (2006) Psychiatric comorbidity and headache: clinical and therapeutical aspects. Neurol Sci 27:S73–S76, 16688633, 10.1007/s10072-006-0574-2PubMedCrossRef

54.

Oedegaard KJ, Neckelmann D, Mykletun A et al (2006) Migraine with and without aura: association with depression and anxiety disorder in a population-based study. The HUNT Study. Cephalalgia 26:1–6, 16396660, 10.1111/j.1468-2982.2005.00974.x, 1:STN:280:DC%2BD28%2FhtVCmsA%3D%3DPubMedCrossRef

55.

Smitherman TA, Baskin SM (2008) Headache secondary to psychiatric disorders. Curr Pain Headache Rep 12(4):305–310, 18625109, 10.1007/s11916-008-0051-0PubMedCrossRef

56.

Lipchik GL, Penzien DB (2004) Psychiatric comorbidities in patients with headaches. Seminars in Pain Medicine, vol 2, No. 2

57.

Merikangas KR, Fenon B, Ramadan NM (1996) Comorbidity and migraine. Semin Headache Manage 1(4):1–10

58.

Pakalnis A, Gibson J, Colvin A (2005) Comorbidity of psychiatric and behavioral disorders in pediatric migraine. Headache 45(5):590–596, 15953278, 10.1111/j.1526-4610.2005.05113.xPubMedCrossRef

59.

Barton-Donovan K, Blanchard EB (2005) Psychosocial aspects of chronic daily headache. J Headahce Pain 6(1):30–39, 10.1007/s10194-005-0147-4CrossRef

60.

Pine DS, Cohen P, Brook J (1996) The association between major depression and headache: results of a epidemiologic study in youth. J Child Adolesc Psychopharmacol 6:153–164, 9231309, 10.1089/cap.1996.6.153, 1:STN:280:DyaK2sznsV2gtg%3D%3DPubMedCrossRef

61.

Sillberstein SD (2001) Shared mechanism and comorbidities in neurologic and psychiatric disorders. Headache 41(Suppl 1):11–17, 10.1046/j.1526-4610.2001.01154-3.xCrossRef

62.

Verbeeck WJC, Berk M, Paiker J, Jersky B (2001) The prolactin response to sulpiride in major depression:the role of the D2 receptor in depression. Eur Neuropsychopharmacol 11(3):215–220, 11418281, 10.1016/S0924-977X(01)00086-4, 1:CAS:528:DC%2BD3MXksVGls7g%3DPubMedCrossRef

63.

Parsey RV, Oquendo MA, Zea-Ponce Y et al (2001) Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression. Biol Psychiatry 50:313–322, 11543733, 10.1016/S0006-3223(01)01089-7, 1:CAS:528:DC%2BD3MXmsFemtrs%3DPubMedCrossRef

64.

Breslau N, Davis GC, Andreski P (1991) Migraine, psychiatric disorders and suicide attempts: an epidemiological study of young adults. Psychiatry Res 37:11–23, 1862159, 10.1016/0165-1781(91)90102-U, 1:STN:280:DyaK3MzhvFynsg%3D%3DPubMedCrossRef

65.

Glover V, Jarman J, Sandler M (1993) Migraine and depression: biological aspects. J Psychiatr Res 2:223–231, 10.1016/0022-3956(93)90010-YCrossRef

Title: Psychiatric disorders and headache familial recurrence: a study on 200 children and their parents
Authors: Federica Galli
Loredana Canzano
Teresa Gloria Scalisi
Vincenzo Guidetti
Publication date: 01-06-2009
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 3/2009
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-009-0105-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Psychiatric disorders and headache familial recurrence: a study on 200 children and their parents

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2009

Sneddon’s syndrome presenting with severe disabling bilateral headache

Cerebral infarct presenting with thunderclap headache

Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review

Study on management of pediatric migraine by general practitioners in northern France

High dietary caffeine consumption is associated with a modest increase in headache prevalence: results from the Head-HUNT Study

Associations between headache and stress, alcohol drinking, exercise, sleep, and comorbid health conditions in a Japanese population