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Open Access 01-04-2008 | Original

Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans

Authors: Ilya Ayzenberg, Mark Oberman, Kirsten Leineweber, Leonora Franke, Min-Suk Yoon, Hans-Christoph Diener, Zaza Katsarava

Published in: The Journal of Headache and Pain | Issue 2/2008

Abstract

We investigated the effect of chronic administration of different pain medications on the activity of the serotonin transporter (SERT) in patients with medication overuse headache (MOH). We measured the kinetic of platelet 5-HT uptake (maximal velocity, V_max and the Michaelis–Menten constant, K_m) in patients with overuse of triptans (tMOH, n = 15) or analgesics (aMOH, n = 14) before and after drug withdrawal, as well as in headache-free healthy subjects (n = 15) and patients with episodic migraine (EM, n = 16). V_max was increased similarly in both, tMOH and aMOH compared to healthy subjects and patients with EM and normalized after withdrawal in parallel to the improvement of headache frequency. Average K_m was similar in all groups at baseline and not affected by the withdrawal. The data demonstrate a transient increase of SERT activity in patients with analgesic and triptan induced MOH but do not allow to differentiate whether the increase of serotonin uptake is caused by regular intake of analgesics or triptans or is a consequence of frequent headache attacks.

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Title: Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans
Authors: Ilya Ayzenberg
Mark Oberman
Kirsten Leineweber
Leonora Franke
Min-Suk Yoon
Hans-Christoph Diener
Zaza Katsarava
Publication date: 01-04-2008
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 2/2008
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-008-0019-9

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Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptans

Abstract

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Abstract

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